Sugi Variant

Sugi Variant/VAV1

VAV1 — 624 ClinVar variants

All ClinVar germline VAV1 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 219 flagged for review →

5 Conflicting · 23 Benign · 5 Benign/Likely benign · 323 Likely benign · 268 Uncertain significance

Full VAV1 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions

⚑ Evidence disagreements 219

Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.

Predictors agree, ClinVar conflicts 3

ClinVar submitters conflict, but the independent predictors unanimously agree — a QC review flag, not a reclassification.

Predictors lean, ClinVar uncertain 155

ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification. · showing the 150 best-reviewed of 155

Predictors split 61

The independent predictors disagree with each other — read with care.

All VAV1 variants

Conflicting classifications of pathogenicity 5

Benign 23

Benign/Likely benign 5

Likely benign 323

Showing the top 300 by review status; the full set is in the sitemap.

Uncertain significance 268