VCAM1 — 94 ClinVar variants
All ClinVar germline VCAM1 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 79 flagged for review →
1 Benign · 13 Likely benign · 80 Uncertain significance
Full VCAM1 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 79
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 62
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- VCAM1 p.Ala11Thr Uncertain significance Single submitter
- VCAM1 p.Ala129Gly Uncertain significance Single submitter
- VCAM1 p.Ala129Thr Uncertain significance Single submitter
- VCAM1 p.Ala168Thr Uncertain significance Single submitter
- VCAM1 p.Ala253Val Uncertain significance Single submitter
- VCAM1 p.Ala639Val Uncertain significance Single submitter
- VCAM1 p.Ala652Thr Uncertain significance Single submitter
- VCAM1 p.Ala663Gly Uncertain significance Single submitter
- VCAM1 p.Arg147Lys Uncertain significance Single submitter
- VCAM1 p.Arg301Lys Uncertain significance Single submitter
- VCAM1 p.Arg435Gln Uncertain significance Single submitter
- VCAM1 p.Asn13Asp Uncertain significance Single submitter
- VCAM1 p.Asn13His Uncertain significance Single submitter
- VCAM1 p.Asn13Tyr Uncertain significance Single submitter
- VCAM1 p.Asn266Thr Uncertain significance Single submitter
- VCAM1 p.Asn300Ser Uncertain significance Single submitter
- VCAM1 p.Asn508Asp Uncertain significance Single submitter
- VCAM1 p.Asn627Lys Uncertain significance Single submitter
- VCAM1 p.Asn691Ser Uncertain significance Single submitter
- VCAM1 p.Asp205Gly Uncertain significance Single submitter
- VCAM1 p.Cys195Trp Uncertain significance Single submitter
- VCAM1 p.Gln503Arg Uncertain significance Single submitter
- VCAM1 p.Gln556Arg Uncertain significance Single submitter
- VCAM1 p.Glu187Gly Uncertain significance Single submitter
- VCAM1 p.Glu410Lys Uncertain significance Single submitter
- VCAM1 p.Glu437Asp Uncertain significance Single submitter
- VCAM1 p.Glu451Gly Uncertain significance Single submitter
- VCAM1 p.Gly10Glu Uncertain significance Single submitter
- VCAM1 p.Gly240Cys Uncertain significance Single submitter
- VCAM1 p.Gly414Ser Uncertain significance Single submitter
- VCAM1 p.Gly553Arg Uncertain significance Single submitter
- VCAM1 p.His157Asn Uncertain significance Single submitter
- VCAM1 p.Ile317Val Uncertain significance Single submitter
- VCAM1 p.Ile351Thr Uncertain significance Single submitter
- VCAM1 p.Ile717Ser Uncertain significance Single submitter
- VCAM1 p.Leu153Val Uncertain significance Single submitter
- VCAM1 p.Leu193Ile Uncertain significance Single submitter
- VCAM1 p.Leu193Phe Uncertain significance Single submitter
- VCAM1 p.Leu36Arg Uncertain significance Single submitter
- VCAM1 p.Leu700Val Uncertain significance Single submitter
- VCAM1 p.Lys160Asn Uncertain significance Single submitter
- VCAM1 p.Lys261Gln Uncertain significance Single submitter
- VCAM1 p.Met332Lys Uncertain significance Single submitter
- VCAM1 p.Met338Val Uncertain significance Single submitter
- VCAM1 p.Phe19Leu Uncertain significance Single submitter
- VCAM1 p.Pro404Arg Uncertain significance Single submitter
- VCAM1 p.Ser361Ile Uncertain significance Single submitter
- VCAM1 p.Ser612Thr Uncertain significance Single submitter
- VCAM1 p.Ser696Ala Uncertain significance Single submitter
- VCAM1 p.Ser706Thr Uncertain significance Single submitter
- VCAM1 p.Thr502Met Uncertain significance Single submitter
- VCAM1 p.Thr563Ile Uncertain significance Single submitter
- VCAM1 p.Thr565Ala Uncertain significance Single submitter
- VCAM1 p.Thr72Met Uncertain significance Single submitter
- VCAM1 p.Thr77Ile Uncertain significance Single submitter
- VCAM1 p.Thr79Met Uncertain significance Single submitter
- VCAM1 p.Thr81Arg Uncertain significance Single submitter
- VCAM1 p.Tyr703Cys Uncertain significance Single submitter
- VCAM1 p.Val337Ala Uncertain significance Single submitter
- VCAM1 p.Val398Leu Uncertain significance Single submitter
- VCAM1 p.Val427Ile Uncertain significance Single submitter
- VCAM1 p.Val482Leu Uncertain significance Single submitter
Predictors split 17
The independent predictors disagree with each other — read with care.
- VCAM1 p.Arg34Gly Uncertain significance Single submitter
- VCAM1 p.Glu399Gln Uncertain significance Single submitter
- VCAM1 p.Gly727Arg Uncertain significance Single submitter
- VCAM1 p.His200Pro Uncertain significance Single submitter
- VCAM1 p.His379Leu Uncertain significance Single submitter
- VCAM1 p.Ile121Ser Uncertain significance Single submitter
- VCAM1 p.Leu152Phe Uncertain significance Single submitter
- VCAM1 p.Leu535Trp Uncertain significance Single submitter
- VCAM1 p.Leu80Val Uncertain significance Single submitter
- VCAM1 p.Lys171Glu Uncertain significance Single submitter
- VCAM1 p.Lys191Arg Uncertain significance Single submitter
- VCAM1 p.Ser233Phe Uncertain significance Single submitter
- VCAM1 p.Ser559Tyr Uncertain significance Single submitter
- VCAM1 p.Ser676Leu Likely benign Single submitter
- VCAM1 p.Val219Ala Uncertain significance Single submitter
- VCAM1 p.Val421Ala Uncertain significance Single submitter
- VCAM1 p.Val71Leu Uncertain significance Single submitter
All VCAM1 variants
Benign 1
- p.His488Arg Multiple submitters
Likely benign 13
- c.341-9C>T Single submitter
- p.Ala129Val Single submitter
- p.Arg322Gln Single submitter
- p.Asn552= Single submitter
- p.Glu554Asp Single submitter
- p.Ile39= Single submitter
- p.Ile649Thr Single submitter
- p.Leu555= Single submitter
- p.Leu9Phe Single submitter
- p.Ser247= Single submitter
- p.Ser248= Single submitter
- p.Ser676Leu Single submitter ⚠
- p.Val576Ile Single submitter
Uncertain significance 80
- p.Ala11Thr Single submitter ⚠
- p.Ala129Gly Single submitter ⚠
- p.Ala129Thr Single submitter ⚠
- p.Ala168Thr Single submitter ⚠
- p.Ala253Val Single submitter ⚠
- p.Ala639Val Single submitter ⚠
- p.Ala652Thr Single submitter ⚠
- p.Ala663Gly Single submitter ⚠
- p.Arg147Lys Single submitter ⚠
- p.Arg301Lys Single submitter ⚠
- p.Arg34Gly Single submitter ⚠
- p.Arg435Gln Single submitter ⚠
- p.Asn13Asp Single submitter ⚠
- p.Asn13His Single submitter ⚠
- p.Asn13Tyr Single submitter ⚠
- p.Asn266Thr Single submitter ⚠
- p.Asn300Ser Single submitter ⚠
- p.Asn508Asp Single submitter ⚠
- p.Asn627Lys Single submitter ⚠
- p.Asn691Ser Single submitter ⚠
- p.Asp205Gly Single submitter ⚠
- p.Cys195Trp Single submitter ⚠
- p.Gln503Arg Single submitter ⚠
- p.Gln556Arg Single submitter ⚠
- p.Glu187Gly Single submitter ⚠
- p.Glu399Gln Single submitter ⚠
- p.Glu410Lys Single submitter ⚠
- p.Glu437Asp Single submitter ⚠
- p.Glu451Gly Single submitter ⚠
- p.Gly10Glu Single submitter ⚠
- p.Gly240Cys Single submitter ⚠
- p.Gly414Ser Single submitter ⚠
- p.Gly553Arg Single submitter ⚠
- p.Gly586Glu Single submitter
- p.Gly727Arg Single submitter ⚠
- p.His157Asn Single submitter ⚠
- p.His200Pro Single submitter ⚠
- p.His379Leu Single submitter ⚠
- p.Ile121Ser Single submitter ⚠
- p.Ile317Val Single submitter ⚠
- p.Ile351Thr Single submitter ⚠
- p.Ile717Ser Single submitter ⚠
- p.Leu152Phe Single submitter ⚠
- p.Leu153Val Single submitter ⚠
- p.Leu193Ile Single submitter ⚠
- p.Leu193Phe Single submitter ⚠
- p.Leu36Arg Single submitter ⚠
- p.Leu535Trp Single submitter ⚠
- p.Leu700Val Single submitter ⚠
- p.Leu80Val Single submitter ⚠
- p.Lys160Asn Single submitter ⚠
- p.Lys171Glu Single submitter ⚠
- p.Lys191Arg Single submitter ⚠
- p.Lys261Gln Single submitter ⚠
- p.Met332Lys Single submitter ⚠
- p.Met338Val Single submitter ⚠
- p.Phe19Leu Single submitter ⚠
- p.Pro404Arg Single submitter ⚠
- p.Ser233Phe Single submitter ⚠
- p.Ser361Ile Single submitter ⚠
- p.Ser559Tyr Single submitter ⚠
- p.Ser612Thr Single submitter ⚠
- p.Ser696Ala Single submitter ⚠
- p.Ser706Thr Single submitter ⚠
- p.Thr349Ile Single submitter
- p.Thr502Met Single submitter ⚠
- p.Thr563Ile Single submitter ⚠
- p.Thr565Ala Single submitter ⚠
- p.Thr72Met Single submitter ⚠
- p.Thr77Ile Single submitter ⚠
- p.Thr79Met Single submitter ⚠
- p.Thr81Arg Single submitter ⚠
- p.Tyr703Cys Single submitter ⚠
- p.Val219Ala Single submitter ⚠
- p.Val337Ala Single submitter ⚠
- p.Val398Leu Single submitter ⚠
- p.Val421Ala Single submitter ⚠
- p.Val427Ile Single submitter ⚠
- p.Val482Leu Single submitter ⚠
- p.Val71Leu Single submitter ⚠