VDAC1 — 24 ClinVar variants
All ClinVar germline VDAC1 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 24 flagged for review →
24 Uncertain significance
Full VDAC1 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 24
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 19
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- VDAC1 p.Ala160Val Uncertain significance Single submitter
- VDAC1 p.Arg15Thr Uncertain significance Single submitter
- VDAC1 p.Arg93His Uncertain significance Single submitter
- VDAC1 p.Asn168Asp Uncertain significance Single submitter
- VDAC1 p.Asn207Ser Uncertain significance Single submitter
- VDAC1 p.Asp9Asn Uncertain significance Single submitter
- VDAC1 p.Glu36Gly Uncertain significance Single submitter
- VDAC1 p.Gly152Ser Uncertain significance Single submitter
- VDAC1 p.Gly213Arg Uncertain significance Single submitter
- VDAC1 p.Gly254Val Uncertain significance Single submitter
- VDAC1 p.Gly68Arg Uncertain significance Single submitter
- VDAC1 p.Lys61Asn Uncertain significance Single submitter
- VDAC1 p.Ser43Ile Uncertain significance Single submitter
- VDAC1 p.Thr217Met Uncertain significance Single submitter
- VDAC1 p.Thr55Met Uncertain significance Single submitter
- VDAC1 p.Tyr118Cys Uncertain significance Single submitter
- VDAC1 p.Tyr146Cys Uncertain significance Single submitter
- VDAC1 p.Tyr62Asn Uncertain significance Single submitter
- VDAC1 p.Val268Ile Uncertain significance Single submitter
Predictors split 5
The independent predictors disagree with each other — read with care.
All VDAC1 variants
Uncertain significance 24
- p.Ala160Val Single submitter ⚠
- p.Arg15Thr Single submitter ⚠
- p.Arg93His Single submitter ⚠
- p.Asn168Asp Single submitter ⚠
- p.Asn168Ser Single submitter ⚠
- p.Asn185Lys Single submitter ⚠
- p.Asn207Ser Single submitter ⚠
- p.Asp9Asn Single submitter ⚠
- p.Glu36Gly Single submitter ⚠
- p.Gly152Ser Single submitter ⚠
- p.Gly213Arg Single submitter ⚠
- p.Gly254Val Single submitter ⚠
- p.Gly68Arg Single submitter ⚠
- p.Lys61Asn Single submitter ⚠
- p.Phe131Leu Single submitter ⚠
- p.Pro253Arg Single submitter ⚠
- p.Ser43Ile Single submitter ⚠
- p.Thr217Met Single submitter ⚠
- p.Thr55Met Single submitter ⚠
- p.Thr80Ile Single submitter ⚠
- p.Tyr118Cys Single submitter ⚠
- p.Tyr146Cys Single submitter ⚠
- p.Tyr62Asn Single submitter ⚠
- p.Val268Ile Single submitter ⚠