VDAC3 — 31 ClinVar variants
All ClinVar germline VDAC3 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 28 flagged for review →
31 Uncertain significance
Full VDAC3 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 28
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 21
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- VDAC3 p.Ala145Val Uncertain significance Single submitter
- VDAC3 p.Ala176Val Uncertain significance Single submitter
- VDAC3 p.Ala212Thr Uncertain significance Single submitter
- VDAC3 p.Ala92Pro Uncertain significance Single submitter
- VDAC3 p.Asn3Ser Uncertain significance Single submitter
- VDAC3 p.Asp78Tyr Uncertain significance Single submitter
- VDAC3 p.Cys36Gly Uncertain significance Single submitter
- VDAC3 p.Gln249Glu Uncertain significance Single submitter
- VDAC3 p.Glu147Lys Uncertain significance Single submitter
- VDAC3 p.Glu200Gly Uncertain significance Single submitter
- VDAC3 p.Gly140Ala Uncertain significance Single submitter
- VDAC3 p.Gly278Glu Uncertain significance Single submitter
- VDAC3 p.His183Tyr Uncertain significance Single submitter
- VDAC3 p.His46Arg Uncertain significance Single submitter
- VDAC3 p.Ile138Val Uncertain significance Single submitter
- VDAC3 p.Lys20Gln Uncertain significance Single submitter
- VDAC3 p.Lys274Arg Uncertain significance Single submitter
- VDAC3 p.Lys61Arg Uncertain significance Single submitter
- VDAC3 p.Pro105Leu Uncertain significance Single submitter
- VDAC3 p.Ser269Thr Uncertain significance Single submitter
- VDAC3 p.Thr188Ile Uncertain significance Single submitter
Predictors split 7
The independent predictors disagree with each other — read with care.
- VDAC3 p.Ala235Thr Uncertain significance Single submitter
- VDAC3 p.Arg218His Uncertain significance Single submitter
- VDAC3 p.Lys174Glu Uncertain significance Single submitter
- VDAC3 p.Lys74Arg Uncertain significance Single submitter
- VDAC3 p.Phe146Leu Uncertain significance Single submitter
- VDAC3 p.Ser44Phe Uncertain significance Single submitter
- VDAC3 p.Thr49Ile Uncertain significance Single submitter
All VDAC3 variants
Uncertain significance 31
- p.Ala145Val Single submitter ⚠
- p.Ala176Val Single submitter ⚠
- p.Ala212Thr Single submitter ⚠
- p.Ala235Thr Single submitter ⚠
- p.Ala92Pro Single submitter ⚠
- p.Arg218His Single submitter ⚠
- p.Asn3Ser Single submitter ⚠
- p.Asp264Asn Single submitter
- p.Asp78Tyr Single submitter ⚠
- p.Cys36Gly Single submitter ⚠
- p.Gln249Glu Single submitter ⚠
- p.Glu147Lys Single submitter ⚠
- p.Glu200Gly Single submitter ⚠
- p.Gly140Ala Single submitter ⚠
- p.Gly278Glu Single submitter ⚠
- p.Gly38Ala Single submitter
- p.His183Tyr Single submitter ⚠
- p.His46Arg Single submitter ⚠
- p.Ile138Val Single submitter ⚠
- p.Lys174Glu Single submitter ⚠
- p.Lys20Gln Single submitter ⚠
- p.Lys274Arg Single submitter ⚠
- p.Lys61Arg Single submitter ⚠
- p.Lys74Arg Single submitter ⚠
- p.Phe146Leu Single submitter ⚠
- p.Pro105Leu Single submitter ⚠
- p.Ser269Thr Single submitter ⚠
- p.Ser44Phe Single submitter ⚠
- p.Thr188Ile Single submitter ⚠
- p.Thr49Ile Single submitter ⚠
- p.Thr51Arg Single submitter