Sugi Variant

Sugi Variant/VEGFC

VEGFC — 100 ClinVar variants

All ClinVar germline VEGFC variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 60 flagged for review →

3 Pathogenic · 3 Conflicting · 19 Benign · 1 Benign/Likely benign · 12 Likely benign · 62 Uncertain significance

Full VEGFC gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions

⚑ Evidence disagreements 60

Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.

Predictors agree, ClinVar conflicts 2

ClinVar submitters conflict, but the independent predictors unanimously agree — a QC review flag, not a reclassification.

Predictors lean, ClinVar uncertain 47

ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.

Predictors split 11

The independent predictors disagree with each other — read with care.

All VEGFC variants

Pathogenic 3

Conflicting classifications of pathogenicity 3

Benign 19

Benign/Likely benign 1

Likely benign 12

Uncertain significance 62