VGF — 112 ClinVar variants
All ClinVar germline VGF variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 102 flagged for review →
4 Benign · 1 Benign/Likely benign · 5 Likely benign · 102 Uncertain significance
Full VGF gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 102
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 85
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- VGF p.Ala149Val Uncertain significance Single submitter
- VGF p.Ala160Glu Uncertain significance Single submitter
- VGF p.Ala181Glu Uncertain significance Single submitter
- VGF p.Ala233Glu Uncertain significance Single submitter
- VGF p.Ala30Val Uncertain significance Single submitter
- VGF p.Ala355Val Uncertain significance Single submitter
- VGF p.Ala496Ser Uncertain significance Single submitter
- VGF p.Ala496Thr Uncertain significance Single submitter
- VGF p.Ala496Val Uncertain significance Single submitter
- VGF p.Ala512Val Uncertain significance Single submitter
- VGF p.Ala569Thr Uncertain significance Single submitter
- VGF p.Ala583Gly Uncertain significance Single submitter
- VGF p.Ala81Val Uncertain significance Single submitter
- VGF p.Arg176Leu Uncertain significance Single submitter
- VGF p.Arg194Gln Uncertain significance Single submitter
- VGF p.Arg234Pro Uncertain significance Single submitter
- VGF p.Arg349Gln Uncertain significance Single submitter
- VGF p.Arg349Trp Uncertain significance Single submitter
- VGF p.Arg428Gln Uncertain significance Single submitter
- VGF p.Arg428Pro Uncertain significance Single submitter
- VGF p.Arg429Gln Uncertain significance Single submitter
- VGF p.Arg517Leu Uncertain significance Single submitter
- VGF p.Arg553Gln Uncertain significance Single submitter
- VGF p.Arg596Trp Uncertain significance Single submitter
- VGF p.Arg80Gln Uncertain significance Single submitter
- VGF p.Asn548Ser Uncertain significance Single submitter
- VGF p.Asp467Val Uncertain significance Single submitter
- VGF p.Asp522Tyr Uncertain significance Single submitter
- VGF p.Asp531Tyr Uncertain significance Single submitter
- VGF p.Asp91Asn Uncertain significance Single submitter
- VGF p.Gln178Glu Uncertain significance Single submitter
- VGF p.Gln316Lys Uncertain significance Single submitter
- VGF p.Gln334Arg Uncertain significance Single submitter
- VGF p.Glu108Lys Uncertain significance Single submitter
- VGF p.Glu165Gln Uncertain significance Single submitter
- VGF p.Glu184Gln Uncertain significance Single submitter
- VGF p.Glu219Asp Uncertain significance Single submitter
- VGF p.Glu29Lys Uncertain significance Single submitter
- VGF p.Glu363Gly Uncertain significance Single submitter
- VGF p.Glu366Lys Uncertain significance Single submitter
- VGF p.Glu431Asp Uncertain significance Single submitter
- VGF p.Glu519Lys Uncertain significance Single submitter
- VGF p.Glu534Asp Uncertain significance Single submitter
- VGF p.Glu589Ala Uncertain significance Single submitter
- VGF p.Glu66Lys Uncertain significance Single submitter
- VGF p.Gly439Glu Uncertain significance Single submitter
- VGF p.His427Tyr Uncertain significance Single submitter
- VGF p.His565Arg Uncertain significance Single submitter
- VGF p.His575Asp Uncertain significance Single submitter
- VGF p.His575Tyr Uncertain significance Single submitter
- VGF p.Ile17Thr Uncertain significance Single submitter
- VGF p.Leu197Val Uncertain significance Single submitter
- VGF p.Leu241His Uncertain significance Single submitter
- VGF p.Leu262Trp Uncertain significance Single submitter
- VGF p.Leu603Pro Uncertain significance Single submitter
- VGF p.Lys40Glu Uncertain significance Single submitter
- VGF p.Pro143Arg Uncertain significance Single submitter
- VGF p.Pro225Ser Uncertain significance Single submitter
- VGF p.Pro226Ser Uncertain significance Single submitter
- VGF p.Pro24Leu Uncertain significance Single submitter
- VGF p.Pro264Ser Uncertain significance Single submitter
- VGF p.Pro282Ser Uncertain significance Single submitter
- VGF p.Pro490Ser Uncertain significance Single submitter
- VGF p.Pro492Leu Uncertain significance Single submitter
- VGF p.Pro493Arg Uncertain significance Single submitter
- VGF p.Pro493His Uncertain significance Single submitter
- VGF p.Pro494His Uncertain significance Single submitter
- VGF p.Pro508Leu Uncertain significance Single submitter
- VGF p.Pro509Leu Uncertain significance Single submitter
- VGF p.Pro515Leu Uncertain significance Single submitter
- VGF p.Pro542Gln Uncertain significance Single submitter
- VGF p.Pro545Arg Uncertain significance Single submitter
- VGF p.Pro93Ser Uncertain significance Single submitter
- VGF p.Pro96Leu Uncertain significance Single submitter
- VGF p.Pro96Ser Uncertain significance Single submitter
- VGF p.Ser150Thr Uncertain significance Single submitter
- VGF p.Ser173Gly Uncertain significance Single submitter
- VGF p.Ser253Phe Uncertain significance Single submitter
- VGF p.Ser266Pro Uncertain significance Single submitter
- VGF p.Ser284Arg Uncertain significance Single submitter
- VGF p.Ser573Leu Uncertain significance Single submitter
- VGF p.Tyr566Phe Uncertain significance Single submitter
- VGF p.Val491Met Uncertain significance Single submitter
- VGF p.Val503Ala Uncertain significance Single submitter
- VGF p.Val503Ile Uncertain significance Single submitter
Predictors split 17
The independent predictors disagree with each other — read with care.
- VGF p.Ala586Pro Uncertain significance Single submitter
- VGF p.Asn196Asp Uncertain significance Single submitter
- VGF p.Asp330Glu Uncertain significance Single submitter
- VGF p.Glu165Lys Uncertain significance Single submitter
- VGF p.Glu179Lys Uncertain significance Single submitter
- VGF p.Glu366Gly Uncertain significance Single submitter
- VGF p.Glu604Lys Uncertain significance Single submitter
- VGF p.Gly211Arg Uncertain significance Single submitter
- VGF p.Leu162Gln Uncertain significance Single submitter
- VGF p.Leu333Phe Uncertain significance Single submitter
- VGF p.Phe213Leu Uncertain significance Single submitter
- VGF p.Pro79Ser Uncertain significance Single submitter
- VGF p.Thr123Ile Uncertain significance Single submitter
- VGF p.Thr187Ile Uncertain significance Single submitter
- VGF p.Thr191Arg Uncertain significance Single submitter
- VGF p.Tyr335Phe Uncertain significance Single submitter
- VGF p.Val217Gly Uncertain significance Single submitter
All VGF variants
Benign 4
- p.Arg308= Multiple submitters
- p.Glu107Gln Multiple submitters
- p.Leu327= Multiple submitters
- p.Gly271= Single submitter
Benign/Likely benign 1
- p.Pro492= Multiple submitters
Likely benign 5
- p.Arg419= Single submitter
- p.Arg495= Single submitter
- p.Glu442Asp Single submitter
- p.Gly248= Single submitter
- p.Gly434= Single submitter
Uncertain significance 102
- p.Ala149Val Single submitter ⚠
- p.Ala160Glu Single submitter ⚠
- p.Ala181Glu Single submitter ⚠
- p.Ala233Glu Single submitter ⚠
- p.Ala30Val Single submitter ⚠
- p.Ala355Val Single submitter ⚠
- p.Ala496Ser Single submitter ⚠
- p.Ala496Thr Single submitter ⚠
- p.Ala496Val Single submitter ⚠
- p.Ala512Val Single submitter ⚠
- p.Ala569Thr Single submitter ⚠
- p.Ala583Gly Single submitter ⚠
- p.Ala586Pro Single submitter ⚠
- p.Ala81Val Single submitter ⚠
- p.Arg176Leu Single submitter ⚠
- p.Arg194Gln Single submitter ⚠
- p.Arg234Pro Single submitter ⚠
- p.Arg349Gln Single submitter ⚠
- p.Arg349Trp Single submitter ⚠
- p.Arg428Gln Single submitter ⚠
- p.Arg428Pro Single submitter ⚠
- p.Arg429Gln Single submitter ⚠
- p.Arg517Leu Single submitter ⚠
- p.Arg553Gln Single submitter ⚠
- p.Arg596Trp Single submitter ⚠
- p.Arg80Gln Single submitter ⚠
- p.Asn196Asp Single submitter ⚠
- p.Asn548Ser Single submitter ⚠
- p.Asp330Glu Single submitter ⚠
- p.Asp467Val Single submitter ⚠
- p.Asp522Tyr Single submitter ⚠
- p.Asp531Tyr Single submitter ⚠
- p.Asp91Asn Single submitter ⚠
- p.Gln178Glu Single submitter ⚠
- p.Gln316Lys Single submitter ⚠
- p.Gln334Arg Single submitter ⚠
- p.Glu108Lys Single submitter ⚠
- p.Glu165Gln Single submitter ⚠
- p.Glu165Lys Single submitter ⚠
- p.Glu179Lys Single submitter ⚠
- p.Glu184Gln Single submitter ⚠
- p.Glu219Asp Single submitter ⚠
- p.Glu29Lys Single submitter ⚠
- p.Glu363Gly Single submitter ⚠
- p.Glu366Gly Single submitter ⚠
- p.Glu366Lys Single submitter ⚠
- p.Glu431Asp Single submitter ⚠
- p.Glu519Lys Single submitter ⚠
- p.Glu534Asp Single submitter ⚠
- p.Glu589Ala Single submitter ⚠
- p.Glu604Lys Single submitter ⚠
- p.Glu66Lys Single submitter ⚠
- p.Gly211Arg Single submitter ⚠
- p.Gly439Glu Single submitter ⚠
- p.His427Tyr Single submitter ⚠
- p.His565Arg Single submitter ⚠
- p.His575Asp Single submitter ⚠
- p.His575Tyr Single submitter ⚠
- p.Ile17Thr Single submitter ⚠
- p.Leu162Gln Single submitter ⚠
- p.Leu197Val Single submitter ⚠
- p.Leu241His Single submitter ⚠
- p.Leu262Trp Single submitter ⚠
- p.Leu333Phe Single submitter ⚠
- p.Leu603Pro Single submitter ⚠
- p.Lys40Glu Single submitter ⚠
- p.Phe213Leu Single submitter ⚠
- p.Pro143Arg Single submitter ⚠
- p.Pro225Ser Single submitter ⚠
- p.Pro226Ser Single submitter ⚠
- p.Pro24Leu Single submitter ⚠
- p.Pro264Ser Single submitter ⚠
- p.Pro282Ser Single submitter ⚠
- p.Pro490Ser Single submitter ⚠
- p.Pro492Leu Single submitter ⚠
- p.Pro493Arg Single submitter ⚠
- p.Pro493His Single submitter ⚠
- p.Pro494His Single submitter ⚠
- p.Pro508Leu Single submitter ⚠
- p.Pro509Leu Single submitter ⚠
- p.Pro515Leu Single submitter ⚠
- p.Pro542Gln Single submitter ⚠
- p.Pro545Arg Single submitter ⚠
- p.Pro79Ser Single submitter ⚠
- p.Pro93Ser Single submitter ⚠
- p.Pro96Leu Single submitter ⚠
- p.Pro96Ser Single submitter ⚠
- p.Ser150Thr Single submitter ⚠
- p.Ser173Gly Single submitter ⚠
- p.Ser253Phe Single submitter ⚠
- p.Ser266Pro Single submitter ⚠
- p.Ser284Arg Single submitter ⚠
- p.Ser573Leu Single submitter ⚠
- p.Thr123Ile Single submitter ⚠
- p.Thr187Ile Single submitter ⚠
- p.Thr191Arg Single submitter ⚠
- p.Tyr335Phe Single submitter ⚠
- p.Tyr566Phe Single submitter ⚠
- p.Val217Gly Single submitter ⚠
- p.Val491Met Single submitter ⚠
- p.Val503Ala Single submitter ⚠
- p.Val503Ile Single submitter ⚠