VIL1 — 142 ClinVar variants
All ClinVar germline VIL1 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 109 flagged for review →
6 Benign · 13 Likely benign · 123 Uncertain significance
Full VIL1 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 109
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 94
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- VIL1 p.Arg505Gln Uncertain significance Multiple submitters
- VIL1 p.Ala123Val Uncertain significance Single submitter
- VIL1 p.Ala218Ser Uncertain significance Single submitter
- VIL1 p.Ala252Val Uncertain significance Single submitter
- VIL1 p.Ala311Gly Uncertain significance Single submitter
- VIL1 p.Ala351Thr Uncertain significance Single submitter
- VIL1 p.Ala525Thr Uncertain significance Single submitter
- VIL1 p.Ala530Thr Uncertain significance Single submitter
- VIL1 p.Ala535Val Uncertain significance Single submitter
- VIL1 p.Ala602Asp Uncertain significance Single submitter
- VIL1 p.Ala673Val Uncertain significance Single submitter
- VIL1 p.Ala743Thr Uncertain significance Single submitter
- VIL1 p.Arg162Gln Uncertain significance Single submitter
- VIL1 p.Arg184Cys Uncertain significance Single submitter
- VIL1 p.Arg233His Uncertain significance Single submitter
- VIL1 p.Arg354Gln Uncertain significance Single submitter
- VIL1 p.Arg404His Uncertain significance Single submitter
- VIL1 p.Arg495Cys Uncertain significance Single submitter
- VIL1 p.Arg495His Uncertain significance Single submitter
- VIL1 p.Arg814Gln Uncertain significance Single submitter
- VIL1 p.Arg92Gln Uncertain significance Single submitter
- VIL1 p.Arg92Leu Uncertain significance Single submitter
- VIL1 p.Asn132Ser Uncertain significance Single submitter
- VIL1 p.Asn407Lys Uncertain significance Single submitter
- VIL1 p.Asn527Thr Uncertain significance Single submitter
- VIL1 p.Asp242Asn Uncertain significance Single submitter
- VIL1 p.Asp727His Uncertain significance Single submitter
- VIL1 p.Gln200Arg Uncertain significance Single submitter
- VIL1 p.Gln329Lys Uncertain significance Single submitter
- VIL1 p.Glu105Asp Uncertain significance Single submitter
- VIL1 p.Glu201Gln Uncertain significance Single submitter
- VIL1 p.Glu262Lys Uncertain significance Single submitter
- VIL1 p.Glu484Gly Uncertain significance Single submitter
- VIL1 p.Glu612Lys Uncertain significance Single submitter
- VIL1 p.Glu744Asp Uncertain significance Single submitter
- VIL1 p.Glu782Lys Uncertain significance Single submitter
- VIL1 p.Glu796Lys Uncertain significance Single submitter
- VIL1 p.Glu98Lys Uncertain significance Single submitter
- VIL1 p.Gly10Ala Uncertain significance Single submitter
- VIL1 p.Gly121Cys Uncertain significance Single submitter
- VIL1 p.Gly190Ala Uncertain significance Single submitter
- VIL1 p.Gly522Arg Uncertain significance Single submitter
- VIL1 p.His228Tyr Uncertain significance Single submitter
- VIL1 p.His702Arg Uncertain significance Single submitter
- VIL1 p.His96Gln Uncertain significance Single submitter
- VIL1 p.Ile287Leu Uncertain significance Single submitter
- VIL1 p.Ile617Val Uncertain significance Single submitter
- VIL1 p.Ile766Val Uncertain significance Single submitter
- VIL1 p.Leu140Pro Uncertain significance Single submitter
- VIL1 p.Leu236Val Uncertain significance Single submitter
- VIL1 p.Leu466Val Uncertain significance Single submitter
- VIL1 p.Leu548Phe Uncertain significance Single submitter
- VIL1 p.Leu793Gln Uncertain significance Single submitter
- VIL1 p.Lys172Asn Uncertain significance Single submitter
- VIL1 p.Lys237Met Uncertain significance Single submitter
- VIL1 p.Lys250Arg Uncertain significance Single submitter
- VIL1 p.Lys374Asn Uncertain significance Single submitter
- VIL1 p.Lys416Arg Uncertain significance Single submitter
- VIL1 p.Lys469Thr Uncertain significance Single submitter
- VIL1 p.Lys789Arg Uncertain significance Single submitter
- VIL1 p.Met126Arg Uncertain significance Single submitter
- VIL1 p.Met155Thr Uncertain significance Single submitter
- VIL1 p.Met481Val Uncertain significance Single submitter
- VIL1 p.Met572Val Uncertain significance Single submitter
- VIL1 p.Phe802Ser Uncertain significance Single submitter
- VIL1 p.Phe827Cys Uncertain significance Single submitter
- VIL1 p.Pro17Leu Uncertain significance Single submitter
- VIL1 p.Ser313Arg Uncertain significance Single submitter
- VIL1 p.Ser327Asn Uncertain significance Single submitter
- VIL1 p.Ser35Asn Uncertain significance Single submitter
- VIL1 p.Ser5Ile Uncertain significance Single submitter
- VIL1 p.Ser71Phe Uncertain significance Single submitter
- VIL1 p.Thr363Ile Uncertain significance Single submitter
- VIL1 p.Thr511Ile Uncertain significance Single submitter
- VIL1 p.Thr580Ala Uncertain significance Single submitter
- VIL1 p.Thr607Ile Uncertain significance Single submitter
- VIL1 p.Thr83Ala Uncertain significance Single submitter
- VIL1 p.Val148Met Uncertain significance Single submitter
- VIL1 p.Val165Ile Uncertain significance Single submitter
- VIL1 p.Val240Met Uncertain significance Single submitter
- VIL1 p.Val266Met Uncertain significance Single submitter
- VIL1 p.Val32Ile Uncertain significance Single submitter
- VIL1 p.Val341Ile Uncertain significance Single submitter
- VIL1 p.Val367Met Uncertain significance Single submitter
- VIL1 p.Val370Leu Uncertain significance Single submitter
- VIL1 p.Val373Ala Uncertain significance Single submitter
- VIL1 p.Val386Met Uncertain significance Single submitter
- VIL1 p.Val402Leu Uncertain significance Single submitter
- VIL1 p.Val498Ile Uncertain significance Single submitter
- VIL1 p.Val698Ala Uncertain significance Single submitter
- VIL1 p.Val750Leu Uncertain significance Single submitter
- VIL1 p.Val773Met Uncertain significance Single submitter
- VIL1 p.Val99Ala Uncertain significance Single submitter
-
VIL1 p.Tyr81His
Uncertain significance
No assertion criteria
VIL1-related disorder
Predictors split 15
The independent predictors disagree with each other — read with care.
- VIL1 p.Arg118Trp Uncertain significance Single submitter
- VIL1 p.Arg198Gln Uncertain significance Single submitter
- VIL1 p.Arg202Gln Uncertain significance Single submitter
- VIL1 p.Arg579Trp Uncertain significance Single submitter
- VIL1 p.Asn626Lys Uncertain significance Single submitter
- VIL1 p.His128Leu Uncertain significance Single submitter
- VIL1 p.Leu548Ile Uncertain significance Single submitter
- VIL1 p.Lys664Asn Uncertain significance Single submitter
- VIL1 p.Pro220Arg Uncertain significance Single submitter
- VIL1 p.Pro220Leu Uncertain significance Single submitter
- VIL1 p.Pro694Arg Uncertain significance Single submitter
- VIL1 p.Ser339Leu Uncertain significance Single submitter
- VIL1 p.Val122Met Uncertain significance Single submitter
- VIL1 p.Val129Met Uncertain significance Single submitter
-
VIL1 p.Arg92Trp
Benign
No assertion criteria
VIL1-related disorder
All VIL1 variants
Benign 6
- p.Ala673= Multiple submitters
- p.Arg630Cys Multiple submitters
- p.Asn593Lys Multiple submitters
- p.Val258Leu Multiple submitters
- p.Arg92Trp No assertion criteria VIL1-related disorder ⚠
- p.Gly43Asp No assertion criteria VIL1-related disorder
Likely benign 13
- p.His228Gln Multiple submitters
- c.2229+8C>T Single submitter
- p.Ala351Val Single submitter
- p.His702= Single submitter
- p.Val136Ile Single submitter
- p.Val445Ile Single submitter
- c.568-3C>T No assertion criteria VIL1-related disorder
- c.75+8C>G No assertion criteria VIL1-related disorder
- c.948+3A>T No assertion criteria VIL1-related disorder
- p.Ala6Thr No assertion criteria VIL1-related disorder
- p.Ile491= No assertion criteria VIL1-related disorder
- p.Leu443= No assertion criteria VIL1-related disorder
- p.Val400= No assertion criteria VIL1-related disorder
Uncertain significance 123
- p.Arg505Gln Multiple submitters ⚠
- p.Ala123Val Single submitter ⚠
- p.Ala218Ser Single submitter ⚠
- p.Ala252Val Single submitter ⚠
- p.Ala303Val Single submitter
- p.Ala311Gly Single submitter ⚠
- p.Ala351Thr Single submitter ⚠
- p.Ala525Thr Single submitter ⚠
- p.Ala530Thr Single submitter ⚠
- p.Ala535Val Single submitter ⚠
- p.Ala602Asp Single submitter ⚠
- p.Ala673Val Single submitter ⚠
- p.Ala743Thr Single submitter ⚠
- p.Arg118Trp Single submitter ⚠
- p.Arg162Gln Single submitter ⚠
- p.Arg184Cys Single submitter ⚠
- p.Arg198Gln Single submitter ⚠
- p.Arg202Gln Single submitter ⚠
- p.Arg233His Single submitter ⚠
- p.Arg354Gln Single submitter ⚠
- p.Arg404His Single submitter ⚠
- p.Arg478Leu Single submitter
- p.Arg495Cys Single submitter ⚠
- p.Arg495His Single submitter ⚠
- p.Arg567Gln Single submitter
- p.Arg579Trp Single submitter ⚠
- p.Arg620Trp Single submitter
- p.Arg814Gln Single submitter ⚠
- p.Arg92Gln Single submitter ⚠
- p.Arg92Leu Single submitter ⚠
- p.Asn132Ser Single submitter ⚠
- p.Asn407Lys Single submitter ⚠
- p.Asn527Thr Single submitter ⚠
- p.Asn626Lys Single submitter ⚠
- p.Asp242Asn Single submitter ⚠
- p.Asp425Asn Single submitter
- p.Asp61Glu Single submitter
- p.Asp727His Single submitter ⚠
- p.Gln200Arg Single submitter ⚠
- p.Gln329Lys Single submitter ⚠
- p.Glu105Asp Single submitter ⚠
- p.Glu201Gln Single submitter ⚠
- p.Glu262Lys Single submitter ⚠
- p.Glu484Gly Single submitter ⚠
- p.Glu612Lys Single submitter ⚠
- p.Glu744Asp Single submitter ⚠
- p.Glu782Lys Single submitter ⚠
- p.Glu796Lys Single submitter ⚠
- p.Glu98Lys Single submitter ⚠
- p.Gly10Ala Single submitter ⚠
- p.Gly121Cys Single submitter ⚠
- p.Gly190Ala Single submitter ⚠
- p.Gly292Arg Single submitter
- p.Gly502Val Single submitter
- p.Gly522Arg Single submitter ⚠
- p.Gly561Ser Single submitter
- p.His128Leu Single submitter ⚠
- p.His228Tyr Single submitter ⚠
- p.His702Arg Single submitter ⚠
- p.His96Gln Single submitter ⚠
- p.Ile287Leu Single submitter ⚠
- p.Ile617Val Single submitter ⚠
- p.Ile766Val Single submitter ⚠
- p.Leu140Pro Single submitter ⚠
- p.Leu236Val Single submitter ⚠
- p.Leu466Val Single submitter ⚠
- p.Leu548Ile Single submitter ⚠
- p.Leu548Phe Single submitter ⚠
- p.Leu793Gln Single submitter ⚠
- p.Lys172Asn Single submitter ⚠
- p.Lys237Met Single submitter ⚠
- p.Lys250Arg Single submitter ⚠
- p.Lys374Asn Single submitter ⚠
- p.Lys416Arg Single submitter ⚠
- p.Lys469Thr Single submitter ⚠
- p.Lys664Asn Single submitter ⚠
- p.Lys789Arg Single submitter ⚠
- p.Met126Arg Single submitter ⚠
- p.Met155Thr Single submitter ⚠
- p.Met481Val Single submitter ⚠
- p.Met572Val Single submitter ⚠
- p.Phe375Val Single submitter
- p.Phe802Ser Single submitter ⚠
- p.Phe827Cys Single submitter ⚠
- p.Pro17Leu Single submitter ⚠
- p.Pro220Arg Single submitter ⚠
- p.Pro220Leu Single submitter ⚠
- p.Pro694Arg Single submitter ⚠
- p.Ser156Phe Single submitter
- p.Ser313Arg Single submitter ⚠
- p.Ser327Asn Single submitter ⚠
- p.Ser339Leu Single submitter ⚠
- p.Ser35Asn Single submitter ⚠
- p.Ser5Ile Single submitter ⚠
- p.Ser71Phe Single submitter ⚠
- p.Thr363Ile Single submitter ⚠
- p.Thr511Ile Single submitter ⚠
- p.Thr580Ala Single submitter ⚠
- p.Thr607Ile Single submitter ⚠
- p.Thr83Ala Single submitter ⚠
- p.Trp417Arg Single submitter
- p.Tyr604Cys Single submitter
- p.Val122Met Single submitter ⚠
- p.Val129Met Single submitter ⚠
- p.Val148Met Single submitter ⚠
- p.Val165Ile Single submitter ⚠
- p.Val240Met Single submitter ⚠
- p.Val266Met Single submitter ⚠
- p.Val297Met Single submitter
- p.Val32Ile Single submitter ⚠
- p.Val341Ile Single submitter ⚠
- p.Val367Met Single submitter ⚠
- p.Val370Leu Single submitter ⚠
- p.Val373Ala Single submitter ⚠
- p.Val386Met Single submitter ⚠
- p.Val402Leu Single submitter ⚠
- p.Val498Ile Single submitter ⚠
- p.Val698Ala Single submitter ⚠
- p.Val750Leu Single submitter ⚠
- p.Val773Met Single submitter ⚠
- p.Val99Ala Single submitter ⚠
- p.Thr706fs No assertion criteria VIL1-related disorder
- p.Tyr81His No assertion criteria VIL1-related disorder ⚠