Sugi Variant

Sugi Variant/VIM

VIM — 127 ClinVar variants

All ClinVar germline VIM variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 61 flagged for review →

1 Pathogenic · 1 Pathogenic/Likely pathogenic · 1 Likely pathogenic · 23 Benign · 4 Benign/Likely benign · 31 Likely benign · 66 Uncertain significance

Full VIM gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions

⚑ Evidence disagreements 61

Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.

Predictors lean, ClinVar uncertain 43

ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.

Predictors split 18

The independent predictors disagree with each other — read with care.

All VIM variants

Pathogenic 1

Pathogenic/Likely pathogenic 1

  • p.Val6fs No assertion criteria Developmental cataract

Likely pathogenic 1

  • p.Leu387Pro No assertion criteria syndrome with premature-aging

Benign 23

Benign/Likely benign 4

Likely benign 31

Uncertain significance 66