VIP — 39 ClinVar variants
All ClinVar germline VIP variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 26 flagged for review →
2 Benign · 1 Benign/Likely benign · 7 Likely benign · 29 Uncertain significance
Full VIP gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 26
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 19
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- VIP p.Ala25Pro Uncertain significance Single submitter
- VIP p.Asn133Ser Uncertain significance Single submitter
- VIP p.Asn68Ser Uncertain significance Single submitter
- VIP p.Glu104Asp Uncertain significance Single submitter
- VIP p.Glu169Lys Uncertain significance Single submitter
- VIP p.Glu48Ala Uncertain significance Single submitter
- VIP p.Leu10Val Uncertain significance Single submitter
- VIP p.Leu147Phe Uncertain significance Single submitter
- VIP p.Leu35Phe Uncertain significance Single submitter
- VIP p.Phe20Leu Uncertain significance Single submitter
- VIP p.Pro162Leu Uncertain significance Single submitter
- VIP p.Ser157Arg Uncertain significance Single submitter
- VIP p.Ser17Cys Uncertain significance Single submitter
- VIP p.Trp26Cys Uncertain significance Single submitter
- VIP p.Tyr102Asn Uncertain significance Single submitter
- VIP p.Val111Ile Uncertain significance Single submitter
- VIP p.Val120Leu Uncertain significance Single submitter
- VIP p.Val18Ala Uncertain significance Single submitter
- VIP p.Val85Asp Uncertain significance Single submitter
Predictors split 7
The independent predictors disagree with each other — read with care.
- VIP p.Ala142Ser Uncertain significance Single submitter
- VIP p.Gly153Arg Uncertain significance Single submitter
- VIP p.Ile150Phe Uncertain significance Single submitter
- VIP p.Leu61Ser Uncertain significance Single submitter
- VIP p.Ser113Cys Uncertain significance Single submitter
- VIP p.Ser33Cys Uncertain significance Single submitter
- VIP p.Thr135Ile Uncertain significance Single submitter
All VIP variants
Benign/Likely benign 1
- c.230+6T>A Multiple submitters
Likely benign 7
- c.231-7G>A Multiple submitters
- p.Asn114= Single submitter
- p.Asp132= Single submitter
- p.Asp163Asn Single submitter
- p.Leu16= Single submitter
- p.Pro71= Single submitter
- p.Ser156= Single submitter
Uncertain significance 29
- p.Ala142Ser Single submitter ⚠
- p.Ala25Pro Single submitter ⚠
- p.Asn133Ser Single submitter ⚠
- p.Asn68Ser Single submitter ⚠
- p.Glu104Asp Single submitter ⚠
- p.Glu104Gly Single submitter
- p.Glu169Lys Single submitter ⚠
- p.Glu48Ala Single submitter ⚠
- p.Gly153Arg Single submitter ⚠
- p.Ile150Phe Single submitter ⚠
- p.Leu10Val Single submitter ⚠
- p.Leu147Phe Single submitter ⚠
- p.Leu35Phe Single submitter ⚠
- p.Leu61Ser Single submitter ⚠
- p.Phe20Leu Single submitter ⚠
- p.Pro162Leu Single submitter ⚠
- p.Ser105Tyr Single submitter
- p.Ser113Cys Single submitter ⚠
- p.Ser157Arg Single submitter ⚠
- p.Ser17Cys Single submitter ⚠
- p.Ser33Cys Single submitter ⚠
- p.Ser91Gly Single submitter
- p.Thr135Ile Single submitter ⚠
- p.Trp26Cys Single submitter ⚠
- p.Tyr102Asn Single submitter ⚠
- p.Val111Ile Single submitter ⚠
- p.Val120Leu Single submitter ⚠
- p.Val18Ala Single submitter ⚠
- p.Val85Asp Single submitter ⚠