VIPR2 — 58 ClinVar variants
All ClinVar germline VIPR2 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 47 flagged for review →
3 Benign · 1 Benign/Likely benign · 5 Likely benign · 49 Uncertain significance
Full VIPR2 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 47
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 40
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- VIPR2 p.Ala345Thr Uncertain significance Single submitter
- VIPR2 p.Ala418Asp Uncertain significance Single submitter
- VIPR2 p.Arg423His Uncertain significance Single submitter
- VIPR2 p.Arg426Leu Uncertain significance Single submitter
- VIPR2 p.Asn413Lys Uncertain significance Single submitter
- VIPR2 p.Asp107Asn Uncertain significance Single submitter
- VIPR2 p.Asp194Glu Uncertain significance Single submitter
- VIPR2 p.Asp314Asn Uncertain significance Single submitter
- VIPR2 p.Asp314Val Uncertain significance Single submitter
- VIPR2 p.Cys38Tyr Uncertain significance Single submitter
- VIPR2 p.Gln367Lys Uncertain significance Single submitter
- VIPR2 p.Glu385Lys Uncertain significance Single submitter
- VIPR2 p.Gly270Ser Uncertain significance Single submitter
- VIPR2 p.Gly316Ser Uncertain significance Single submitter
- VIPR2 p.Gly368Ser Uncertain significance Single submitter
- VIPR2 p.Gly417Arg Uncertain significance Single submitter
- VIPR2 p.His277Tyr Uncertain significance Single submitter
- VIPR2 p.Ile21Val Uncertain significance Single submitter
- VIPR2 p.Ile256Leu Uncertain significance Single submitter
- VIPR2 p.Ile438Val Uncertain significance Single submitter
- VIPR2 p.Leu209Pro Uncertain significance Single submitter
- VIPR2 p.Leu230His Uncertain significance Single submitter
- VIPR2 p.Leu264Phe Uncertain significance Single submitter
- VIPR2 p.Leu264Val Uncertain significance Single submitter
- VIPR2 p.Leu419Pro Uncertain significance Single submitter
- VIPR2 p.Leu431Arg Uncertain significance Single submitter
- VIPR2 p.Lys328Arg Uncertain significance Single submitter
- VIPR2 p.Phe208Leu Uncertain significance Single submitter
- VIPR2 p.Pro114Leu Uncertain significance Single submitter
- VIPR2 p.Pro193Ser Uncertain significance Single submitter
- VIPR2 p.Ser400Thr Uncertain significance Single submitter
- VIPR2 p.Ser408Phe Uncertain significance Single submitter
- VIPR2 p.Ser408Tyr Uncertain significance Single submitter
- VIPR2 p.Ser409Phe Uncertain significance Single submitter
- VIPR2 p.Thr269Ser Uncertain significance Single submitter
- VIPR2 p.Thr330Met Uncertain significance Single submitter
- VIPR2 p.Thr433Arg Uncertain significance Single submitter
- VIPR2 p.Thr72Met Uncertain significance Single submitter
- VIPR2 p.Trp272Arg Uncertain significance Single submitter
- VIPR2 p.Val339Ile Uncertain significance Single submitter
Predictors split 7
The independent predictors disagree with each other — read with care.
- VIPR2 p.Arg393Pro Uncertain significance Single submitter
- VIPR2 p.Cys362Tyr Likely benign Single submitter
- VIPR2 p.Gln322Leu Uncertain significance Single submitter
- VIPR2 p.Gly54Ser Uncertain significance Single submitter
- VIPR2 p.Pro335Leu Uncertain significance Single submitter
- VIPR2 p.Pro348Ala Uncertain significance Single submitter
- VIPR2 p.Trp281Ser Uncertain significance Single submitter
All VIPR2 variants
Benign 3
- p.Phe410Ser Multiple submitters
- p.Ala173= Single submitter
- p.Thr94= Single submitter
Benign/Likely benign 1
- p.Pro335= Multiple submitters
Likely benign 5
- p.Cys362Tyr Single submitter ⚠
- p.Gly417= Single submitter
- p.Leu361= Single submitter
- p.Pro397Gln Single submitter
- p.Val106Ile Single submitter
Uncertain significance 49
- p.Ala345Thr Single submitter ⚠
- p.Ala418Asp Single submitter ⚠
- p.Arg393Pro Single submitter ⚠
- p.Arg423His Single submitter ⚠
- p.Arg426Leu Single submitter ⚠
- p.Asn413Lys Single submitter ⚠
- p.Asp107Asn Single submitter ⚠
- p.Asp194Glu Single submitter ⚠
- p.Asp314Asn Single submitter ⚠
- p.Asp314Val Single submitter ⚠
- p.Cys38Tyr Single submitter ⚠
- p.Gln322Leu Single submitter ⚠
- p.Gln367Lys Single submitter ⚠
- p.Glu385Lys Single submitter ⚠
- p.Gly110Asp Single submitter
- p.Gly270Ser Single submitter ⚠
- p.Gly316Ser Single submitter ⚠
- p.Gly368Ser Single submitter ⚠
- p.Gly417Arg Single submitter ⚠
- p.Gly54Ser Single submitter ⚠
- p.His277Tyr Single submitter ⚠
- p.Ile21Val Single submitter ⚠
- p.Ile256Leu Single submitter ⚠
- p.Ile438Val Single submitter ⚠
- p.Leu209Pro Single submitter ⚠
- p.Leu230His Single submitter ⚠
- p.Leu264Phe Single submitter ⚠
- p.Leu264Val Single submitter ⚠
- p.Leu419Pro Single submitter ⚠
- p.Leu431Arg Single submitter ⚠
- p.Lys328Arg Single submitter ⚠
- p.Phe208Leu Single submitter ⚠
- p.Pro114Leu Single submitter ⚠
- p.Pro193Ser Single submitter ⚠
- p.Pro335Leu Single submitter ⚠
- p.Pro348Ala Single submitter ⚠
- p.Ser400Thr Single submitter ⚠
- p.Ser408Phe Single submitter ⚠
- p.Ser408Tyr Single submitter ⚠
- p.Ser409Phe Single submitter ⚠
- p.Thr269Ser Single submitter ⚠
- p.Thr330Met Single submitter ⚠
- p.Thr433Arg Single submitter ⚠
- p.Thr72Met Single submitter ⚠
- p.Thr94Met Single submitter
- p.Trp272Arg Single submitter ⚠
- p.Trp281Ser Single submitter ⚠
- p.Val339Ile Single submitter ⚠
- c.51+37G>A No assertion criteria myoepithelial tumor