Sugi Variant

Sugi Variant/VMA22

VMA22 — 50 ClinVar variants

All ClinVar germline VMA22 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 16 flagged for review →

3 Pathogenic · 1 Likely pathogenic · 2 Conflicting · 6 Benign · 1 Benign/Likely benign · 18 Likely benign · 19 Uncertain significance

Full VMA22 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions

⚑ Evidence disagreements 16

Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.

Predictors agree, ClinVar conflicts 1

ClinVar submitters conflict, but the independent predictors unanimously agree — a QC review flag, not a reclassification.

Predictors lean, ClinVar uncertain 11

ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.

Predictors split 4

The independent predictors disagree with each other — read with care.

All VMA22 variants

Pathogenic 3

Likely pathogenic 1

Conflicting classifications of pathogenicity 2

Benign 6

Benign/Likely benign 1

Likely benign 18

Uncertain significance 19