VMP1 — 26 ClinVar variants
All ClinVar germline VMP1 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 22 flagged for review →
2 Likely benign · 24 Uncertain significance
Full VMP1 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 22
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 20
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- VMP1 p.Arg38Gln Uncertain significance Single submitter
- VMP1 p.Asn153Ser Uncertain significance Single submitter
- VMP1 p.Asn7Ser Uncertain significance Single submitter
- VMP1 p.Gln42His Uncertain significance Single submitter
- VMP1 p.Gln55His Uncertain significance Single submitter
- VMP1 p.Glu18Lys Uncertain significance Single submitter
- VMP1 p.His315Leu Uncertain significance Single submitter
- VMP1 p.Ile189Thr Uncertain significance Single submitter
- VMP1 p.Leu282Val Uncertain significance Single submitter
- VMP1 p.Leu381Val Uncertain significance Single submitter
- VMP1 p.Leu54Phe Uncertain significance Single submitter
- VMP1 p.Phe227Ser Uncertain significance Single submitter
- VMP1 p.Phe24Cys Uncertain significance Single submitter
- VMP1 p.Phe258Leu Uncertain significance Single submitter
- VMP1 p.Pro204Leu Uncertain significance Single submitter
- VMP1 p.Ser81Thr Uncertain significance Single submitter
- VMP1 p.Thr174Ser Uncertain significance Single submitter
- VMP1 p.Thr277Met Uncertain significance Single submitter
- VMP1 p.Tyr162Cys Uncertain significance Single submitter
- VMP1 p.Val373Ile Uncertain significance Single submitter
Predictors split 2
The independent predictors disagree with each other — read with care.
All VMP1 variants
Likely benign 2
- p.His20Tyr Single submitter
- p.Thr177Ala Single submitter
Uncertain significance 24
- p.Arg38Gln Single submitter ⚠
- p.Asn153Ser Single submitter ⚠
- p.Asn7Ser Single submitter ⚠
- p.Gln42His Single submitter ⚠
- p.Gln55His Single submitter ⚠
- p.Glu18Lys Single submitter ⚠
- p.His315Leu Single submitter ⚠
- p.Ile189Thr Single submitter ⚠
- p.Ile383Leu Single submitter
- p.Leu282Val Single submitter ⚠
- p.Leu381Val Single submitter ⚠
- p.Leu54Phe Single submitter ⚠
- p.Phe227Ser Single submitter ⚠
- p.Phe24Cys Single submitter ⚠
- p.Phe258Leu Single submitter ⚠
- p.Pro158Ser Single submitter ⚠
- p.Pro204Leu Single submitter ⚠
- p.Ser365Phe Single submitter ⚠
- p.Ser81Thr Single submitter ⚠
- p.Thr174Ser Single submitter ⚠
- p.Thr277Met Single submitter ⚠
- p.Tyr162Cys Single submitter ⚠
- p.Val373Ile Single submitter ⚠
- p.Leu111fs No assertion criteria Monoclonal B-Cell Lymphocytosis