VNN1 — 74 ClinVar variants
All ClinVar germline VNN1 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 59 flagged for review →
8 Benign · 6 Likely benign · 60 Uncertain significance
Full VNN1 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 59
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 47
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- VNN1 p.Ala174Ser Uncertain significance Single submitter
- VNN1 p.Ala33Gly Uncertain significance Single submitter
- VNN1 p.Ala33Thr Uncertain significance Single submitter
- VNN1 p.Ala33Val Uncertain significance Single submitter
- VNN1 p.Arg112Cys Uncertain significance Single submitter
- VNN1 p.Arg392Pro Uncertain significance Single submitter
- VNN1 p.Asn113Lys Uncertain significance Single submitter
- VNN1 p.Asn283Ile Uncertain significance Single submitter
- VNN1 p.Asp23Asn Uncertain significance Single submitter
- VNN1 p.Asp23Glu Uncertain significance Single submitter
- VNN1 p.Cys109Ser Uncertain significance Single submitter
- VNN1 p.Cys509Arg Uncertain significance Single submitter
- VNN1 p.Gln179Lys Uncertain significance Single submitter
- VNN1 p.Gln396Leu Uncertain significance Single submitter
- VNN1 p.Glu295Asp Uncertain significance Single submitter
- VNN1 p.Glu48Lys Uncertain significance Single submitter
- VNN1 p.Gly385Glu Uncertain significance Single submitter
- VNN1 p.Gly477Glu Uncertain significance Single submitter
- VNN1 p.His228Arg Uncertain significance Single submitter
- VNN1 p.Ile323Leu Uncertain significance Single submitter
- VNN1 p.Ile323Val Uncertain significance Single submitter
- VNN1 p.Ile82Val Uncertain significance Single submitter
- VNN1 p.Leu245Ser Uncertain significance Single submitter
- VNN1 p.Leu300Val Uncertain significance Single submitter
- VNN1 p.Leu301Phe Uncertain significance Single submitter
- VNN1 p.Leu60Ser Uncertain significance Single submitter
- VNN1 p.Phe14Ser Uncertain significance Single submitter
- VNN1 p.Phe166Leu Uncertain significance Single submitter
- VNN1 p.Phe203Leu Uncertain significance Single submitter
- VNN1 p.Pro108Leu Uncertain significance Single submitter
- VNN1 p.Pro243Ser Uncertain significance Single submitter
- VNN1 p.Pro465Thr Uncertain significance Single submitter
- VNN1 p.Ser20Gly Uncertain significance Single submitter
- VNN1 p.Ser271Pro Uncertain significance Single submitter
- VNN1 p.Ser284Phe Uncertain significance Single submitter
- VNN1 p.Ser327Pro Uncertain significance Single submitter
- VNN1 p.Ser510Leu Uncertain significance Single submitter
- VNN1 p.Thr147Asn Uncertain significance Single submitter
- VNN1 p.Thr210Ile Uncertain significance Single submitter
- VNN1 p.Thr222Ala Uncertain significance Single submitter
- VNN1 p.Tyr354Phe Uncertain significance Single submitter
- VNN1 p.Val221Ala Uncertain significance Single submitter
- VNN1 p.Val224Glu Uncertain significance Single submitter
- VNN1 p.Val241Ile Uncertain significance Single submitter
- VNN1 p.Val29Leu Uncertain significance Single submitter
- VNN1 p.Val377Met Uncertain significance Single submitter
- VNN1 p.Val9Met Uncertain significance Single submitter
Predictors split 12
The independent predictors disagree with each other — read with care.
- VNN1 p.Arg157His Likely benign Multiple submitters
- VNN1 p.Arg175His Uncertain significance Single submitter
- VNN1 p.Arg55Trp Uncertain significance Single submitter
- VNN1 p.Gln159Glu Uncertain significance Single submitter
- VNN1 p.His177Arg Uncertain significance Single submitter
- VNN1 p.His32Tyr Uncertain significance Single submitter
- VNN1 p.Pro153Ser Uncertain significance Single submitter
- VNN1 p.Pro469Thr Uncertain significance Single submitter
- VNN1 p.Ser302Leu Uncertain significance Single submitter
- VNN1 p.Thr231Ile Uncertain significance Single submitter
- VNN1 p.Tyr290Cys Uncertain significance Single submitter
- VNN1 p.Val165Ile Uncertain significance Single submitter
All VNN1 variants
Benign 8
- c.827-3C>T Single submitter
- p.Ala325Glu Single submitter
- p.Ala72= Single submitter
- p.Asp146Asn Single submitter
- p.Glu296Asp Single submitter
- p.Ile373Thr Single submitter
- p.Ter514Gln Single submitter
- p.Val136Leu Single submitter
Likely benign 6
- p.Arg112His Multiple submitters
- p.Arg157His Multiple submitters ⚠
- p.Ala505Thr Single submitter
- p.Arg55Gln Single submitter
- p.Asn130Asp Single submitter
- p.Val233Leu Single submitter
Uncertain significance 60
- p.Ala174Ser Single submitter ⚠
- p.Ala33Gly Single submitter ⚠
- p.Ala33Thr Single submitter ⚠
- p.Ala33Val Single submitter ⚠
- p.Arg112Cys Single submitter ⚠
- p.Arg175His Single submitter ⚠
- p.Arg392Pro Single submitter ⚠
- p.Arg55Trp Single submitter ⚠
- p.Asn113Lys Single submitter ⚠
- p.Asn283Ile Single submitter ⚠
- p.Asn56Ser Single submitter
- p.Asp23Asn Single submitter ⚠
- p.Asp23Glu Single submitter ⚠
- p.Cys109Ser Single submitter ⚠
- p.Cys509Arg Single submitter ⚠
- p.Gln159Glu Single submitter ⚠
- p.Gln179Lys Single submitter ⚠
- p.Gln396Leu Single submitter ⚠
- p.Glu295Asp Single submitter ⚠
- p.Glu48Lys Single submitter ⚠
- p.Gly385Glu Single submitter ⚠
- p.Gly477Glu Single submitter ⚠
- p.His177Arg Single submitter ⚠
- p.His228Arg Single submitter ⚠
- p.His32Tyr Single submitter ⚠
- p.Ile323Leu Single submitter ⚠
- p.Ile323Val Single submitter ⚠
- p.Ile82Val Single submitter ⚠
- p.Leu245Ser Single submitter ⚠
- p.Leu300Val Single submitter ⚠
- p.Leu301Phe Single submitter ⚠
- p.Leu60Ser Single submitter ⚠
- p.Phe14Ser Single submitter ⚠
- p.Phe166Leu Single submitter ⚠
- p.Phe203Leu Single submitter ⚠
- p.Pro108Leu Single submitter ⚠
- p.Pro153Ser Single submitter ⚠
- p.Pro243Ser Single submitter ⚠
- p.Pro465Thr Single submitter ⚠
- p.Pro469Thr Single submitter ⚠
- p.Ser20Gly Single submitter ⚠
- p.Ser271Pro Single submitter ⚠
- p.Ser284Phe Single submitter ⚠
- p.Ser302Leu Single submitter ⚠
- p.Ser302Trp Single submitter
- p.Ser327Pro Single submitter ⚠
- p.Ser510Leu Single submitter ⚠
- p.Thr147Asn Single submitter ⚠
- p.Thr210Ile Single submitter ⚠
- p.Thr222Ala Single submitter ⚠
- p.Thr231Ile Single submitter ⚠
- p.Tyr290Cys Single submitter ⚠
- p.Tyr354Phe Single submitter ⚠
- p.Val165Ile Single submitter ⚠
- p.Val221Ala Single submitter ⚠
- p.Val224Glu Single submitter ⚠
- p.Val241Ile Single submitter ⚠
- p.Val29Leu Single submitter ⚠
- p.Val377Met Single submitter ⚠
- p.Val9Met Single submitter ⚠