VPS26A — 32 ClinVar variants
All ClinVar germline VPS26A variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 29 flagged for review →
1 Likely benign · 31 Uncertain significance
Full VPS26A gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 29
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 23
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- VPS26A p.Arg262Lys Uncertain significance Single submitter
- VPS26A p.Asn125Ser Uncertain significance Single submitter
- VPS26A p.Glu146Ala Uncertain significance Single submitter
- VPS26A p.Gly99Ala Uncertain significance Single submitter
- VPS26A p.Ile11Val Uncertain significance Single submitter
- VPS26A p.Ile122Phe Uncertain significance Single submitter
- VPS26A p.Ile136Thr Uncertain significance Single submitter
- VPS26A p.Ile230Val Uncertain significance Single submitter
- VPS26A p.Leu101Met Uncertain significance Single submitter
- VPS26A p.Leu276Val Uncertain significance Single submitter
- VPS26A p.Lys35Arg Uncertain significance Single submitter
- VPS26A p.Met112Thr Uncertain significance Single submitter
- VPS26A p.Met207Val Uncertain significance Single submitter
- VPS26A p.Phe88Tyr Uncertain significance Single submitter
- VPS26A p.Ser104Thr Uncertain significance Single submitter
- VPS26A p.Thr102Ile Uncertain significance Single submitter
- VPS26A p.Tyr40His Uncertain significance Single submitter
- VPS26A p.Tyr43Cys Uncertain significance Single submitter
- VPS26A p.Val134Met Uncertain significance Single submitter
- VPS26A p.Val160Ile Uncertain significance Single submitter
- VPS26A p.Val17Ile Uncertain significance Single submitter
- VPS26A p.Val36Ala Uncertain significance Single submitter
- VPS26A p.Val48Ile Uncertain significance Single submitter
Predictors split 6
The independent predictors disagree with each other — read with care.
- VPS26A p.Ala231Thr Uncertain significance Single submitter
- VPS26A p.Arg127Cys Uncertain significance Single submitter
- VPS26A p.Gln75His Uncertain significance Single submitter
- VPS26A p.His152Gln Uncertain significance Single submitter
- VPS26A p.Lys133Thr Uncertain significance Single submitter
- VPS26A p.Tyr40Ser Uncertain significance Single submitter
All VPS26A variants
Likely benign 1
- p.Leu294= Single submitter
Uncertain significance 31
- p.Ala231Thr Single submitter ⚠
- p.Ala298Val Single submitter
- p.Arg127Cys Single submitter ⚠
- p.Arg262Lys Single submitter ⚠
- p.Asn125Ser Single submitter ⚠
- p.Gln75His Single submitter ⚠
- p.Glu146Ala Single submitter ⚠
- p.Gly99Ala Single submitter ⚠
- p.His152Gln Single submitter ⚠
- p.Ile11Val Single submitter ⚠
- p.Ile122Phe Single submitter ⚠
- p.Ile136Thr Single submitter ⚠
- p.Ile230Val Single submitter ⚠
- p.Leu101Met Single submitter ⚠
- p.Leu187Ile Single submitter
- p.Leu276Val Single submitter ⚠
- p.Lys133Thr Single submitter ⚠
- p.Lys35Arg Single submitter ⚠
- p.Met112Thr Single submitter ⚠
- p.Met207Val Single submitter ⚠
- p.Phe88Tyr Single submitter ⚠
- p.Ser104Thr Single submitter ⚠
- p.Thr102Ile Single submitter ⚠
- p.Tyr40His Single submitter ⚠
- p.Tyr40Ser Single submitter ⚠
- p.Tyr43Cys Single submitter ⚠
- p.Val134Met Single submitter ⚠
- p.Val160Ile Single submitter ⚠
- p.Val17Ile Single submitter ⚠
- p.Val36Ala Single submitter ⚠
- p.Val48Ile Single submitter ⚠