VPS28 — 35 ClinVar variants
All ClinVar germline VPS28 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 22 flagged for review →
6 Likely benign · 29 Uncertain significance
Full VPS28 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 22
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 11
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- VPS28 p.Ala51Asp Uncertain significance Single submitter
- VPS28 p.Arg97His Uncertain significance Single submitter
- VPS28 p.Asn16Ser Uncertain significance Single submitter
- VPS28 p.Asp173Asn Uncertain significance Single submitter
- VPS28 p.Gly189Ser Uncertain significance Single submitter
- VPS28 p.His169Tyr Uncertain significance Single submitter
- VPS28 p.Met49Thr Uncertain significance Single submitter
- VPS28 p.Pro104Leu Uncertain significance Single submitter
- VPS28 p.Pro9Leu Uncertain significance Single submitter
- VPS28 p.Thr179Met Uncertain significance Single submitter
- VPS28 p.Thr67Ala Uncertain significance Single submitter
Predictors split 11
The independent predictors disagree with each other — read with care.
- VPS28 p.Ala80Val Uncertain significance Single submitter
- VPS28 p.Arg177Cys Uncertain significance Single submitter
- VPS28 p.Arg177His Uncertain significance Single submitter
- VPS28 p.Arg31Gln Uncertain significance Single submitter
- VPS28 p.Arg97Cys Uncertain significance Single submitter
- VPS28 p.Lys111Glu Uncertain significance Single submitter
- VPS28 p.Lys142Arg Uncertain significance Single submitter
- VPS28 p.Lys17Asn Uncertain significance Single submitter
- VPS28 p.Met150Ile Uncertain significance Single submitter
- VPS28 p.Ser134Ala Uncertain significance Single submitter
- VPS28 p.Ser191Leu Likely benign Single submitter
All VPS28 variants
Likely benign 6
- p.Ala192= Single submitter
- p.Ala192Val Single submitter
- p.Leu125= Single submitter
- p.Ser188= Single submitter
- p.Ser191= Single submitter
- p.Ser191Leu Single submitter ⚠
Uncertain significance 29
- c.548+57G>C Single submitter
- c.548+9C>T Single submitter
- c.549-21T>C Single submitter
- c.549-23C>T Single submitter
- c.549-51G>A Single submitter
- c.549-5C>T Single submitter
- c.549-9C>T Single submitter
- p.Ala51Asp Single submitter ⚠
- p.Ala80Val Single submitter ⚠
- p.Arg177Cys Single submitter ⚠
- p.Arg177His Single submitter ⚠
- p.Arg31Gln Single submitter ⚠
- p.Arg97Cys Single submitter ⚠
- p.Arg97His Single submitter ⚠
- p.Asn16Ser Single submitter ⚠
- p.Asp173Asn Single submitter ⚠
- p.Gly189Ser Single submitter ⚠
- p.His169Tyr Single submitter ⚠
- p.Lys111Glu Single submitter ⚠
- p.Lys142Arg Single submitter ⚠
- p.Lys17Asn Single submitter ⚠
- p.Met150Ile Single submitter ⚠
- p.Met49Thr Single submitter ⚠
- p.Pro104Leu Single submitter ⚠
- p.Pro18Leu Single submitter
- p.Pro9Leu Single submitter ⚠
- p.Ser134Ala Single submitter ⚠
- p.Thr179Met Single submitter ⚠
- p.Thr67Ala Single submitter ⚠