VRK2 — 104 ClinVar variants
All ClinVar germline VRK2 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 94 flagged for review →
1 Conflicting · 7 Likely benign · 96 Uncertain significance
Full VRK2 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 94
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 81
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
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VRK2 p.Asp435Asn
Uncertain significance
Multiple submitters
Fanconi anemia complementation group L
- VRK2 p.Ala348Ser Uncertain significance Single submitter
- VRK2 p.Ala348Thr Uncertain significance Single submitter
- VRK2 p.Arg123Gly Uncertain significance Single submitter
- VRK2 p.Arg149Gln Uncertain significance Single submitter
- VRK2 p.Arg230Gln Uncertain significance Single submitter
- VRK2 p.Arg242Gln Uncertain significance Single submitter
- VRK2 p.Arg358Lys Uncertain significance Single submitter
- VRK2 p.Arg491Ser Uncertain significance Single submitter
- VRK2 p.Arg92Cys Uncertain significance Single submitter
- VRK2 p.Asn196Ser Uncertain significance Single submitter
- VRK2 p.Asn198Ser Uncertain significance Single submitter
- VRK2 p.Asn27Ser Uncertain significance Single submitter
- VRK2 p.Asn338Ser Uncertain significance Single submitter
- VRK2 p.Asn427Asp Uncertain significance Single submitter
- VRK2 p.Asn67Ile Uncertain significance Single submitter
- VRK2 p.Asn6Asp Uncertain significance Single submitter
- VRK2 p.Asp232Glu Uncertain significance Single submitter
- VRK2 p.Asp269Gly Uncertain significance Single submitter
- VRK2 p.Asp343Val Uncertain significance Single submitter
- VRK2 p.Asp463Ala Uncertain significance Single submitter
- VRK2 p.Asp84Asn Uncertain significance Single submitter
- VRK2 p.Cys286Tyr Uncertain significance Single submitter
- VRK2 p.Cys373Tyr Uncertain significance Single submitter
- VRK2 p.Gln307His Uncertain significance Single submitter
- VRK2 p.Gln330Arg Uncertain significance Single submitter
- VRK2 p.Gln404Glu Uncertain significance Single submitter
- VRK2 p.Gln407Glu Uncertain significance Single submitter
- VRK2 p.Gln418Lys Uncertain significance Single submitter
- VRK2 p.Gln418Pro Uncertain significance Single submitter
- VRK2 p.Glu395Gly Uncertain significance Single submitter
- VRK2 p.Glu405Val Uncertain significance Single submitter
- VRK2 p.Glu408Gly Uncertain significance Single submitter
- VRK2 p.Glu431Ala Uncertain significance Single submitter
- VRK2 p.Glu431Val Uncertain significance Single submitter
- VRK2 p.Glu481Ala Uncertain significance Single submitter
- VRK2 p.Glu63Lys Uncertain significance Single submitter
- VRK2 p.Glu91Ala Uncertain significance Single submitter
- VRK2 p.Gly105Glu Uncertain significance Single submitter
- VRK2 p.Gly175Val Uncertain significance Single submitter
- VRK2 p.Gly212Glu Uncertain significance Single submitter
- VRK2 p.Gly32Asp Uncertain significance Single submitter
- VRK2 p.His316Tyr Uncertain significance Single submitter
- VRK2 p.Ile157Leu Uncertain significance Single submitter
- VRK2 p.Ile157Thr Uncertain significance Single submitter
- VRK2 p.Ile157Val Uncertain significance Single submitter
- VRK2 p.Ile214Thr Uncertain significance Single submitter
- VRK2 p.Ile441Thr Uncertain significance Single submitter
- VRK2 p.Ile441Val Uncertain significance Single submitter
- VRK2 p.Leu276Arg Uncertain significance Single submitter
- VRK2 p.Leu505Phe Uncertain significance Single submitter
- VRK2 p.Lys140Arg Uncertain significance Single submitter
- VRK2 p.Lys328Arg Uncertain significance Single submitter
- VRK2 p.Lys350Met Uncertain significance Single submitter
- VRK2 p.Lys363Arg Uncertain significance Single submitter
- VRK2 p.Lys363Asn Uncertain significance Single submitter
- VRK2 p.Lys443Gln Uncertain significance Single submitter
- VRK2 p.Lys444Arg Uncertain significance Single submitter
- VRK2 p.Lys54Glu Uncertain significance Single submitter
- VRK2 p.Phe138Ser Uncertain significance Single submitter
- VRK2 p.Phe442Ile Uncertain significance Single submitter
- VRK2 p.Phe47Cys Uncertain significance Single submitter
- VRK2 p.Ser369Gly Uncertain significance Single submitter
- VRK2 p.Ser372Tyr Uncertain significance Single submitter
- VRK2 p.Ser415Cys Uncertain significance Single submitter
- VRK2 p.Ser438Gly Uncertain significance Single submitter
- VRK2 p.Thr262Ile Uncertain significance Single submitter
- VRK2 p.Thr336Asn Uncertain significance Single submitter
- VRK2 p.Thr397Ala Uncertain significance Single submitter
- VRK2 p.Thr454Ile Uncertain significance Single submitter
- VRK2 p.Thr456Ile Uncertain significance Single submitter
- VRK2 p.Thr473Ile Uncertain significance Single submitter
- VRK2 p.Thr483Ile Uncertain significance Single submitter
- VRK2 p.Tyr104His Uncertain significance Single submitter
- VRK2 p.Tyr187Cys Uncertain significance Single submitter
- VRK2 p.Tyr306Cys Uncertain significance Single submitter
- VRK2 p.Tyr490Cys Uncertain significance Single submitter
- VRK2 p.Val120Leu Uncertain significance Single submitter
- VRK2 p.Val182Phe Uncertain significance Single submitter
- VRK2 p.Val342Ala Uncertain significance Single submitter
- VRK2 p.Val364Ile Uncertain significance Single submitter
Predictors split 13
The independent predictors disagree with each other — read with care.
- VRK2 p.Arg242Trp Uncertain significance Single submitter
- VRK2 p.Asn305His Uncertain significance Single submitter
- VRK2 p.Asn314Lys Uncertain significance Single submitter
- VRK2 p.Gly175Asp Uncertain significance Single submitter
- VRK2 p.Gly209Arg Uncertain significance Single submitter
- VRK2 p.Leu323Val Uncertain significance Single submitter
- VRK2 p.Lys247Glu Uncertain significance Single submitter
- VRK2 p.Phe71Tyr Uncertain significance Single submitter
- VRK2 p.Thr142Ala Uncertain significance Single submitter
- VRK2 p.Thr217Ala Uncertain significance Single submitter
- VRK2 p.Tyr104Ser Uncertain significance Single submitter
- VRK2 p.Tyr202Cys Uncertain significance Single submitter
- VRK2 p.Val62Met Uncertain significance Single submitter
All VRK2 variants
Conflicting classifications of pathogenicity 1
- c.*102_*105dup Single submitter Hereditary cancer
Likely benign 7
- p.Tyr422= Multiple submitters Fanconi anemia complementation group L
- p.Asn305Asp Single submitter
- p.His356Gln Single submitter
- p.Leu410= Single submitter
- p.Met388Leu Single submitter
- p.Ser458Gly Single submitter
- p.Trp376Arg Single submitter
Uncertain significance 96
- p.Asp435Asn Multiple submitters Fanconi anemia complementation group L ⚠
- p.Ala348Ser Single submitter ⚠
- p.Ala348Thr Single submitter ⚠
- p.Arg123Gly Single submitter ⚠
- p.Arg149Gln Single submitter ⚠
- p.Arg230Gln Single submitter ⚠
- p.Arg242Gln Single submitter ⚠
- p.Arg242Trp Single submitter ⚠
- p.Arg358Lys Single submitter ⚠
- p.Arg491Ser Single submitter ⚠
- p.Arg92Cys Single submitter ⚠
- p.Asn196Ser Single submitter ⚠
- p.Asn198Ser Single submitter ⚠
- p.Asn27Ser Single submitter ⚠
- p.Asn305His Single submitter ⚠
- p.Asn314Lys Single submitter ⚠
- p.Asn338Ser Single submitter ⚠
- p.Asn427Asp Single submitter ⚠
- p.Asn67Ile Single submitter ⚠
- p.Asn6Asp Single submitter ⚠
- p.Asp232Glu Single submitter ⚠
- p.Asp269Gly Single submitter ⚠
- p.Asp343Val Single submitter ⚠
- p.Asp463Ala Single submitter ⚠
- p.Asp84Asn Single submitter ⚠
- p.Cys286Tyr Single submitter ⚠
- p.Cys373Tyr Single submitter ⚠
- p.Gln307His Single submitter ⚠
- p.Gln330Arg Single submitter ⚠
- p.Gln404Glu Single submitter ⚠
- p.Gln407Glu Single submitter ⚠
- p.Gln418Lys Single submitter ⚠
- p.Gln418Pro Single submitter ⚠
- p.Glu395Gly Single submitter ⚠
- p.Glu405Val Single submitter ⚠
- p.Glu408Gly Single submitter ⚠
- p.Glu431Ala Single submitter ⚠
- p.Glu431Val Single submitter ⚠
- p.Glu481Ala Single submitter ⚠
- p.Glu63Lys Single submitter ⚠
- p.Glu91Ala Single submitter ⚠
- p.Gly105Glu Single submitter ⚠
- p.Gly175Asp Single submitter ⚠
- p.Gly175Val Single submitter ⚠
- p.Gly209Arg Single submitter ⚠
- p.Gly212Glu Single submitter ⚠
- p.Gly32Asp Single submitter ⚠
- p.Gly99Ala Single submitter
- p.His316Tyr Single submitter ⚠
- p.Ile157Leu Single submitter ⚠
- p.Ile157Thr Single submitter ⚠
- p.Ile157Val Single submitter ⚠
- p.Ile214Thr Single submitter ⚠
- p.Ile441Thr Single submitter ⚠
- p.Ile441Val Single submitter ⚠
- p.Leu276Arg Single submitter ⚠
- p.Leu323Val Single submitter ⚠
- p.Leu505Phe Single submitter ⚠
- p.Lys140Arg Single submitter ⚠
- p.Lys247Glu Single submitter ⚠
- p.Lys328Arg Single submitter ⚠
- p.Lys350Met Single submitter ⚠
- p.Lys363Arg Single submitter ⚠
- p.Lys363Asn Single submitter ⚠
- p.Lys443Gln Single submitter ⚠
- p.Lys444Arg Single submitter ⚠
- p.Lys54Glu Single submitter ⚠
- p.Phe138Ser Single submitter ⚠
- p.Phe442Ile Single submitter ⚠
- p.Phe47Cys Single submitter ⚠
- p.Phe71Tyr Single submitter ⚠
- p.Pro195Leu Single submitter
- p.Ser369Gly Single submitter ⚠
- p.Ser372Tyr Single submitter ⚠
- p.Ser415Cys Single submitter ⚠
- p.Ser438Gly Single submitter ⚠
- p.Thr142Ala Single submitter ⚠
- p.Thr217Ala Single submitter ⚠
- p.Thr262Ile Single submitter ⚠
- p.Thr336Asn Single submitter ⚠
- p.Thr397Ala Single submitter ⚠
- p.Thr454Ile Single submitter ⚠
- p.Thr456Ile Single submitter ⚠
- p.Thr473Ile Single submitter ⚠
- p.Thr483Ile Single submitter ⚠
- p.Tyr104His Single submitter ⚠
- p.Tyr104Ser Single submitter ⚠
- p.Tyr187Cys Single submitter ⚠
- p.Tyr202Cys Single submitter ⚠
- p.Tyr306Cys Single submitter ⚠
- p.Tyr490Cys Single submitter ⚠
- p.Val120Leu Single submitter ⚠
- p.Val182Phe Single submitter ⚠
- p.Val342Ala Single submitter ⚠
- p.Val364Ile Single submitter ⚠
- p.Val62Met Single submitter ⚠