VSIG8 — 45 ClinVar variants
All ClinVar germline VSIG8 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 42 flagged for review →
2 Likely benign · 43 Uncertain significance
Full VSIG8 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 42
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 36
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- VSIG8 p.Ala169Thr Uncertain significance Single submitter
- VSIG8 p.Ala296Thr Uncertain significance Single submitter
- VSIG8 p.Ala315Val Uncertain significance Single submitter
- VSIG8 p.Ala35Glu Uncertain significance Single submitter
- VSIG8 p.Arg127Gln Uncertain significance Single submitter
- VSIG8 p.Arg127Trp Uncertain significance Single submitter
- VSIG8 p.Arg136Gln Uncertain significance Single submitter
- VSIG8 p.Arg191Gln Uncertain significance Single submitter
- VSIG8 p.Arg23Gln Uncertain significance Single submitter
- VSIG8 p.Arg261His Uncertain significance Single submitter
- VSIG8 p.Arg261Ser Uncertain significance Single submitter
- VSIG8 p.Arg73Pro Uncertain significance Single submitter
- VSIG8 p.Arg98His Uncertain significance Single submitter
- VSIG8 p.Asp162Asn Uncertain significance Single submitter
- VSIG8 p.Asp223Val Uncertain significance Single submitter
- VSIG8 p.Gln198Arg Uncertain significance Single submitter
- VSIG8 p.Gln81Pro Uncertain significance Single submitter
- VSIG8 p.Glu322Lys Uncertain significance Single submitter
- VSIG8 p.Glu36Ala Uncertain significance Single submitter
- VSIG8 p.Gly155Arg Uncertain significance Single submitter
- VSIG8 p.Gly292Arg Uncertain significance Single submitter
- VSIG8 p.Gly43Ser Uncertain significance Single submitter
- VSIG8 p.His186Tyr Uncertain significance Single submitter
- VSIG8 p.His92Arg Uncertain significance Single submitter
- VSIG8 p.Ile111Val Uncertain significance Single submitter
- VSIG8 p.Ile139Val Uncertain significance Single submitter
- VSIG8 p.Ile215Val Uncertain significance Single submitter
- VSIG8 p.Ile266Val Uncertain significance Single submitter
- VSIG8 p.Leu224Arg Uncertain significance Single submitter
- VSIG8 p.Leu34Val Uncertain significance Single submitter
- VSIG8 p.Pro16Ser Uncertain significance Single submitter
- VSIG8 p.Pro55Ser Uncertain significance Single submitter
- VSIG8 p.Val164Met Uncertain significance Single submitter
- VSIG8 p.Val241Ala Uncertain significance Single submitter
- VSIG8 p.Val281Ile Uncertain significance Single submitter
- VSIG8 p.Val47Phe Uncertain significance Single submitter
Predictors split 6
The independent predictors disagree with each other — read with care.
- VSIG8 p.Arg136Trp Uncertain significance Single submitter
- VSIG8 p.Arg98Cys Uncertain significance Single submitter
- VSIG8 p.Glu61Lys Uncertain significance Single submitter
- VSIG8 p.Gly26Arg Uncertain significance Single submitter
- VSIG8 p.Lys137Met Uncertain significance Single submitter
- VSIG8 p.Val264Glu Uncertain significance Single submitter
All VSIG8 variants
Likely benign 2
- p.Gly306Ser Single submitter
- p.Val269Ile Single submitter
Uncertain significance 43
- p.Ala169Thr Single submitter ⚠
- p.Ala296Thr Single submitter ⚠
- p.Ala315Val Single submitter ⚠
- p.Ala35Glu Single submitter ⚠
- p.Arg127Gln Single submitter ⚠
- p.Arg127Trp Single submitter ⚠
- p.Arg136Gln Single submitter ⚠
- p.Arg136Trp Single submitter ⚠
- p.Arg145Ter Single submitter
- p.Arg191Gln Single submitter ⚠
- p.Arg23Gln Single submitter ⚠
- p.Arg261His Single submitter ⚠
- p.Arg261Ser Single submitter ⚠
- p.Arg73Pro Single submitter ⚠
- p.Arg98Cys Single submitter ⚠
- p.Arg98His Single submitter ⚠
- p.Asp162Asn Single submitter ⚠
- p.Asp223Val Single submitter ⚠
- p.Gln198Arg Single submitter ⚠
- p.Gln81Pro Single submitter ⚠
- p.Glu322Lys Single submitter ⚠
- p.Glu36Ala Single submitter ⚠
- p.Glu61Lys Single submitter ⚠
- p.Gly155Arg Single submitter ⚠
- p.Gly26Arg Single submitter ⚠
- p.Gly292Arg Single submitter ⚠
- p.Gly43Ser Single submitter ⚠
- p.His186Tyr Single submitter ⚠
- p.His92Arg Single submitter ⚠
- p.Ile111Val Single submitter ⚠
- p.Ile139Val Single submitter ⚠
- p.Ile215Val Single submitter ⚠
- p.Ile266Val Single submitter ⚠
- p.Leu224Arg Single submitter ⚠
- p.Leu34Val Single submitter ⚠
- p.Lys137Met Single submitter ⚠
- p.Pro16Ser Single submitter ⚠
- p.Pro55Ser Single submitter ⚠
- p.Val164Met Single submitter ⚠
- p.Val241Ala Single submitter ⚠
- p.Val264Glu Single submitter ⚠
- p.Val281Ile Single submitter ⚠
- p.Val47Phe Single submitter ⚠