WASF2 — 60 ClinVar variants
All ClinVar germline WASF2 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 57 flagged for review →
5 Likely benign · 55 Uncertain significance
Full WASF2 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 57
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 41
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- WASF2 p.Ala317Val Uncertain significance Single submitter
- WASF2 p.Ala372Ser Uncertain significance Single submitter
- WASF2 p.Arg451Cys Uncertain significance Single submitter
- WASF2 p.Arg64Trp Uncertain significance Single submitter
- WASF2 p.Arg74Gln Uncertain significance Single submitter
- WASF2 p.Asn135Ser Uncertain significance Single submitter
- WASF2 p.Asp253Gly Uncertain significance Single submitter
- WASF2 p.Asp486Val Uncertain significance Single submitter
- WASF2 p.Asp498Asn Uncertain significance Single submitter
- WASF2 p.Asp498Gly Uncertain significance Single submitter
- WASF2 p.Gln231Lys Uncertain significance Single submitter
- WASF2 p.Gln76Glu Uncertain significance Single submitter
- WASF2 p.Glu145Gln Uncertain significance Single submitter
- WASF2 p.Glu24Lys Uncertain significance Single submitter
- WASF2 p.Glu264Lys Uncertain significance Single submitter
- WASF2 p.Glu88Asp Uncertain significance Single submitter
- WASF2 p.Ile8Val Uncertain significance Single submitter
- WASF2 p.Leu383Phe Uncertain significance Single submitter
- WASF2 p.Leu383Ser Uncertain significance Single submitter
- WASF2 p.Leu420Pro Uncertain significance Single submitter
- WASF2 p.Lys148Arg Uncertain significance Single submitter
- WASF2 p.Lys180Arg Uncertain significance Single submitter
- WASF2 p.Lys427Glu Uncertain significance Single submitter
- WASF2 p.Lys78Glu Uncertain significance Single submitter
- WASF2 p.Lys85Arg Uncertain significance Single submitter
- WASF2 p.Pro226His Uncertain significance Single submitter
- WASF2 p.Pro289Leu Uncertain significance Single submitter
- WASF2 p.Pro305Leu Uncertain significance Single submitter
- WASF2 p.Pro310Thr Uncertain significance Single submitter
- WASF2 p.Pro314Leu Uncertain significance Single submitter
- WASF2 p.Pro320Ala Uncertain significance Single submitter
- WASF2 p.Pro324Ser Uncertain significance Single submitter
- WASF2 p.Pro326Leu Uncertain significance Single submitter
- WASF2 p.Pro333Ser Uncertain significance Single submitter
- WASF2 p.Pro419Leu Uncertain significance Single submitter
- WASF2 p.Ser244Asn Uncertain significance Single submitter
- WASF2 p.Ser257Leu Uncertain significance Single submitter
- WASF2 p.Ser428Phe Uncertain significance Single submitter
- WASF2 p.Ser63Phe Uncertain significance Single submitter
- WASF2 p.Val21Ile Uncertain significance Single submitter
- WASF2 p.Val433Met Uncertain significance Single submitter
Predictors split 16
The independent predictors disagree with each other — read with care.
- WASF2 p.Asn59Asp Uncertain significance Single submitter
- WASF2 p.Asp495Asn Uncertain significance Single submitter
- WASF2 p.Pro271Leu Uncertain significance Single submitter
- WASF2 p.Pro334Ser Likely benign Single submitter
- WASF2 p.Pro347Arg Uncertain significance Single submitter
- WASF2 p.Pro350Arg Uncertain significance Single submitter
- WASF2 p.Pro366Arg Uncertain significance Single submitter
- WASF2 p.Pro376Arg Uncertain significance Single submitter
- WASF2 p.Pro391Ser Uncertain significance Single submitter
- WASF2 p.Pro393Thr Uncertain significance Single submitter
- WASF2 p.Pro398Ser Uncertain significance Single submitter
- WASF2 p.Pro400Leu Uncertain significance Single submitter
- WASF2 p.Pro400Ser Uncertain significance Single submitter
- WASF2 p.Ser474Cys Uncertain significance Single submitter
- WASF2 p.Val28Met Likely benign Single submitter
- WASF2 p.Val77Phe Uncertain significance Single submitter
All WASF2 variants
Likely benign 5
- p.Pro247Leu Multiple submitters
- p.Arg457Gln Single submitter
- p.Pro334Ser Single submitter ⚠
- p.Pro397= Single submitter
- p.Val28Met Single submitter ⚠
Uncertain significance 55
- p.Ala317Val Single submitter ⚠
- p.Ala372Ser Single submitter ⚠
- p.Arg451Cys Single submitter ⚠
- p.Arg64Trp Single submitter ⚠
- p.Arg74Gln Single submitter ⚠
- p.Asn135Ser Single submitter ⚠
- p.Asn59Asp Single submitter ⚠
- p.Asp253Gly Single submitter ⚠
- p.Asp486Val Single submitter ⚠
- p.Asp495Asn Single submitter ⚠
- p.Asp498Asn Single submitter ⚠
- p.Asp498Gly Single submitter ⚠
- p.Gln231Lys Single submitter ⚠
- p.Gln76Glu Single submitter ⚠
- p.Glu145Gln Single submitter ⚠
- p.Glu24Lys Single submitter ⚠
- p.Glu264Lys Single submitter ⚠
- p.Glu88Asp Single submitter ⚠
- p.Ile8Val Single submitter ⚠
- p.Leu383Phe Single submitter ⚠
- p.Leu383Ser Single submitter ⚠
- p.Leu420Pro Single submitter ⚠
- p.Lys148Arg Single submitter ⚠
- p.Lys180Arg Single submitter ⚠
- p.Lys427Glu Single submitter ⚠
- p.Lys78Glu Single submitter ⚠
- p.Lys85Arg Single submitter ⚠
- p.Pro226His Single submitter ⚠
- p.Pro271Leu Single submitter ⚠
- p.Pro289Leu Single submitter ⚠
- p.Pro305Leu Single submitter ⚠
- p.Pro310Thr Single submitter ⚠
- p.Pro314Leu Single submitter ⚠
- p.Pro320Ala Single submitter ⚠
- p.Pro324Ser Single submitter ⚠
- p.Pro326Leu Single submitter ⚠
- p.Pro333Ser Single submitter ⚠
- p.Pro347Arg Single submitter ⚠
- p.Pro350Arg Single submitter ⚠
- p.Pro366Arg Single submitter ⚠
- p.Pro376Arg Single submitter ⚠
- p.Pro391Ser Single submitter ⚠
- p.Pro393Thr Single submitter ⚠
- p.Pro398Ser Single submitter ⚠
- p.Pro400Leu Single submitter ⚠
- p.Pro400Ser Single submitter ⚠
- p.Pro419Leu Single submitter ⚠
- p.Ser244Asn Single submitter ⚠
- p.Ser257Leu Single submitter ⚠
- p.Ser428Phe Single submitter ⚠
- p.Ser474Cys Single submitter ⚠
- p.Ser63Phe Single submitter ⚠
- p.Val21Ile Single submitter ⚠
- p.Val433Met Single submitter ⚠
- p.Val77Phe Single submitter ⚠