WDR33 — 135 ClinVar variants
All ClinVar germline WDR33 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 113 flagged for review →
4 Likely benign · 131 Uncertain significance
Full WDR33 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 113
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 90
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- WDR33 p.Ala1076Val Uncertain significance Single submitter
- WDR33 p.Ala1142Val Uncertain significance Single submitter
- WDR33 p.Ala21Gly Uncertain significance Single submitter
- WDR33 p.Ala502Val Uncertain significance Single submitter
- WDR33 p.Ala797Val Uncertain significance Single submitter
- WDR33 p.Arg1030His Uncertain significance Single submitter
- WDR33 p.Arg1071Gln Uncertain significance Single submitter
- WDR33 p.Arg1086His Uncertain significance Single submitter
- WDR33 p.Arg1089Leu Uncertain significance Single submitter
- WDR33 p.Arg1099His Uncertain significance Single submitter
- WDR33 p.Arg1115His Uncertain significance Single submitter
- WDR33 p.Arg1146Gln Uncertain significance Single submitter
- WDR33 p.Arg1262Gln Uncertain significance Single submitter
- WDR33 p.Arg1276His Uncertain significance Single submitter
- WDR33 p.Arg1308Gln Uncertain significance Single submitter
- WDR33 p.Arg1336Gln Uncertain significance Single submitter
- WDR33 p.Arg853Gln Uncertain significance Single submitter
- WDR33 p.Arg915Trp Uncertain significance Single submitter
- WDR33 p.Arg942Cys Uncertain significance Single submitter
- WDR33 p.Arg974Gln Uncertain significance Single submitter
- WDR33 p.Arg987Lys Uncertain significance Single submitter
- WDR33 p.Arg991Gln Uncertain significance Single submitter
- WDR33 p.Arg991Trp Uncertain significance Single submitter
- WDR33 p.Asn1185Asp Uncertain significance Single submitter
- WDR33 p.Asp1093Glu Uncertain significance Single submitter
- WDR33 p.Asp1207Gly Uncertain significance Single submitter
- WDR33 p.Asp462Gly Uncertain significance Single submitter
- WDR33 p.Cys996Phe Uncertain significance Single submitter
- WDR33 p.Gln486Arg Uncertain significance Single submitter
- WDR33 p.Gln794His Uncertain significance Single submitter
- WDR33 p.Glu1283Gln Uncertain significance Single submitter
- WDR33 p.Gly1114Ser Uncertain significance Single submitter
- WDR33 p.Gly1176Arg Uncertain significance Single submitter
- WDR33 p.Gly1299Ser Uncertain significance Single submitter
- WDR33 p.Gly1331Ser Uncertain significance Single submitter
- WDR33 p.Gly657Glu Uncertain significance Single submitter
- WDR33 p.Gly761Arg Uncertain significance Single submitter
- WDR33 p.Gly786Arg Uncertain significance Single submitter
- WDR33 p.Gly829Asp Uncertain significance Single submitter
- WDR33 p.Gly885Val Uncertain significance Single submitter
- WDR33 p.His1203Arg Uncertain significance Single submitter
- WDR33 p.His1206Gln Uncertain significance Single submitter
- WDR33 p.His814Pro Uncertain significance Single submitter
- WDR33 p.His822Arg Uncertain significance Single submitter
- WDR33 p.His894Tyr Uncertain significance Single submitter
- WDR33 p.Ile228Phe Uncertain significance Single submitter
- WDR33 p.Ile572Val Uncertain significance Single submitter
- WDR33 p.Ile597Ser Uncertain significance Single submitter
- WDR33 p.Ile717Met Uncertain significance Single submitter
- WDR33 p.Ile82Val Uncertain significance Single submitter
- WDR33 p.Leu1039Ser Uncertain significance Single submitter
- WDR33 p.Leu583Pro Uncertain significance Single submitter
- WDR33 p.Leu819Pro Uncertain significance Single submitter
- WDR33 p.Leu819Val Uncertain significance Single submitter
- WDR33 p.Met1247Ile Uncertain significance Single submitter
- WDR33 p.Met372Ile Uncertain significance Single submitter
- WDR33 p.Met38Val Uncertain significance Single submitter
- WDR33 p.Met594Ile Uncertain significance Single submitter
- WDR33 p.Met594Val Uncertain significance Single submitter
- WDR33 p.Met740Val Uncertain significance Single submitter
- WDR33 p.Met79Thr Uncertain significance Single submitter
- WDR33 p.Pro1000Leu Uncertain significance Single submitter
- WDR33 p.Pro1040Leu Uncertain significance Single submitter
- WDR33 p.Pro1053Leu Uncertain significance Single submitter
- WDR33 p.Pro1056Ser Uncertain significance Single submitter
- WDR33 p.Pro1091Ala Uncertain significance Single submitter
- WDR33 p.Pro1094Ser Uncertain significance Single submitter
- WDR33 p.Pro1110Leu Uncertain significance Single submitter
- WDR33 p.Pro1118Ala Uncertain significance Single submitter
- WDR33 p.Pro1118Leu Uncertain significance Single submitter
- WDR33 p.Pro1204Ser Uncertain significance Single submitter
- WDR33 p.Pro1324Leu Uncertain significance Single submitter
- WDR33 p.Pro574Leu Uncertain significance Single submitter
- WDR33 p.Pro629Ser Uncertain significance Single submitter
- WDR33 p.Pro631Ser Uncertain significance Single submitter
- WDR33 p.Pro681Leu Uncertain significance Single submitter
- WDR33 p.Pro681Ser Uncertain significance Single submitter
- WDR33 p.Pro683Ser Uncertain significance Single submitter
- WDR33 p.Pro711Ser Uncertain significance Single submitter
- WDR33 p.Pro806Leu Uncertain significance Single submitter
- WDR33 p.Pro840Leu Uncertain significance Single submitter
- WDR33 p.Pro841Ala Uncertain significance Single submitter
- WDR33 p.Pro848Thr Uncertain significance Single submitter
- WDR33 p.Pro849Leu Uncertain significance Single submitter
- WDR33 p.Pro864Leu Uncertain significance Single submitter
- WDR33 p.Pro889Leu Uncertain significance Single submitter
- WDR33 p.Pro948Ala Uncertain significance Single submitter
- WDR33 p.Thr580Ala Uncertain significance Single submitter
- WDR33 p.Val291Ile Uncertain significance Single submitter
- WDR33 p.Val569Ile Uncertain significance Single submitter
Predictors split 23
The independent predictors disagree with each other — read with care.
- WDR33 p.Arg1046Ser Uncertain significance Single submitter
- WDR33 p.Arg1172Cys Uncertain significance Single submitter
- WDR33 p.Arg80Trp Uncertain significance Single submitter
- WDR33 p.Arg891Ser Uncertain significance Single submitter
- WDR33 p.Asp431Glu Uncertain significance Single submitter
- WDR33 p.Gly1034Glu Uncertain significance Single submitter
- WDR33 p.Gly1331Cys Uncertain significance Single submitter
- WDR33 p.Gly1332Arg Uncertain significance Single submitter
- WDR33 p.Gly257Ala Uncertain significance Single submitter
- WDR33 p.Gly584Arg Uncertain significance Single submitter
- WDR33 p.Gly745Ser Uncertain significance Single submitter
- WDR33 p.Gly795Val Uncertain significance Single submitter
- WDR33 p.Gly913Glu Uncertain significance Single submitter
- WDR33 p.His728Arg Uncertain significance Single submitter
- WDR33 p.Lys906Asn Uncertain significance Single submitter
- WDR33 p.Met1223Thr Uncertain significance Single submitter
- WDR33 p.Pro1234Leu Uncertain significance Single submitter
- WDR33 p.Pro1323Leu Uncertain significance Single submitter
- WDR33 p.Pro628Leu Uncertain significance Single submitter
- WDR33 p.Pro743Leu Uncertain significance Single submitter
- WDR33 p.Pro796Thr Uncertain significance Single submitter
- WDR33 p.Pro880Thr Uncertain significance Single submitter
- WDR33 p.Val226Leu Uncertain significance Single submitter
All WDR33 variants
Likely benign 4
- c.205-36TTTA[9] Single submitter
- c.626+213A>G Single submitter
- p.Pro1074Leu Single submitter
- p.Ser698Asn Single submitter
Uncertain significance 131
- p.Ala1076Val Single submitter ⚠
- p.Ala1142Val Single submitter ⚠
- p.Ala1212Asp Single submitter
- p.Ala21Gly Single submitter ⚠
- p.Ala502Val Single submitter ⚠
- p.Ala797Val Single submitter ⚠
- p.Arg1024Cys Single submitter
- p.Arg1030His Single submitter ⚠
- p.Arg1046Ser Single submitter ⚠
- p.Arg1071Gln Single submitter ⚠
- p.Arg1086Cys Single submitter
- p.Arg1086His Single submitter ⚠
- p.Arg1089Leu Single submitter ⚠
- p.Arg1095Cys Single submitter
- p.Arg1099Cys Single submitter
- p.Arg1099His Single submitter ⚠
- p.Arg1115His Single submitter ⚠
- p.Arg1146Gln Single submitter ⚠
- p.Arg1172Cys Single submitter ⚠
- p.Arg1216His Single submitter
- p.Arg1262Gln Single submitter ⚠
- p.Arg1276His Single submitter ⚠
- p.Arg1276Pro Single submitter
- p.Arg1308Gln Single submitter ⚠
- p.Arg1308Trp Single submitter
- p.Arg1336Gln Single submitter ⚠
- p.Arg1336Trp Single submitter
- p.Arg80Trp Single submitter ⚠
- p.Arg853Gln Single submitter ⚠
- p.Arg891Ser Single submitter ⚠
- p.Arg915Trp Single submitter ⚠
- p.Arg942Cys Single submitter ⚠
- p.Arg960Cys Single submitter
- p.Arg974Gln Single submitter ⚠
- p.Arg987Lys Single submitter ⚠
- p.Arg991Gln Single submitter ⚠
- p.Arg991Trp Single submitter ⚠
- p.Asn1185Asp Single submitter ⚠
- p.Asp1017His Single submitter
- p.Asp1093Glu Single submitter ⚠
- p.Asp1207Gly Single submitter ⚠
- p.Asp431Glu Single submitter ⚠
- p.Asp462Gly Single submitter ⚠
- p.Cys996Phe Single submitter ⚠
- p.Gln483His Single submitter
- p.Gln486Arg Single submitter ⚠
- p.Gln602Arg Single submitter
- p.Gln794His Single submitter ⚠
- p.Glu1283Gln Single submitter ⚠
- p.Gly1026Asp Single submitter
- p.Gly1034Glu Single submitter ⚠
- p.Gly1114Ser Single submitter ⚠
- p.Gly1159Glu Single submitter
- p.Gly1176Arg Single submitter ⚠
- p.Gly1299Ser Single submitter ⚠
- p.Gly1331Cys Single submitter ⚠
- p.Gly1331Ser Single submitter ⚠
- p.Gly1332Arg Single submitter ⚠
- p.Gly257Ala Single submitter ⚠
- p.Gly584Arg Single submitter ⚠
- p.Gly657Glu Single submitter ⚠
- p.Gly745Ser Single submitter ⚠
- p.Gly760Asp Single submitter
- p.Gly761Arg Single submitter ⚠
- p.Gly786Arg Single submitter ⚠
- p.Gly795Val Single submitter ⚠
- p.Gly829Asp Single submitter ⚠
- p.Gly885Val Single submitter ⚠
- p.Gly913Glu Single submitter ⚠
- p.Gly933Val Single submitter
- p.Gly949Glu Single submitter
- p.His1203Arg Single submitter ⚠
- p.His1206Gln Single submitter ⚠
- p.His728Arg Single submitter ⚠
- p.His814Pro Single submitter ⚠
- p.His822Arg Single submitter ⚠
- p.His894Tyr Single submitter ⚠
- p.Ile228Phe Single submitter ⚠
- p.Ile572Val Single submitter ⚠
- p.Ile597Ser Single submitter ⚠
- p.Ile717Met Single submitter ⚠
- p.Ile82Val Single submitter ⚠
- p.Leu1039Ser Single submitter ⚠
- p.Leu583Pro Single submitter ⚠
- p.Leu819Pro Single submitter ⚠
- p.Leu819Val Single submitter ⚠
- p.Lys906Asn Single submitter ⚠
- p.Met1223Thr Single submitter ⚠
- p.Met1247Ile Single submitter ⚠
- p.Met372Ile Single submitter ⚠
- p.Met38Val Single submitter ⚠
- p.Met594Ile Single submitter ⚠
- p.Met594Val Single submitter ⚠
- p.Met740Val Single submitter ⚠
- p.Met79Thr Single submitter ⚠
- p.Pro1000Leu Single submitter ⚠
- p.Pro1040Leu Single submitter ⚠
- p.Pro1053Leu Single submitter ⚠
- p.Pro1056Ser Single submitter ⚠
- p.Pro1091Ala Single submitter ⚠
- p.Pro1094Ser Single submitter ⚠
- p.Pro1110Leu Single submitter ⚠
- p.Pro1118Ala Single submitter ⚠
- p.Pro1118Leu Single submitter ⚠
- p.Pro1204Ser Single submitter ⚠
- p.Pro1234Leu Single submitter ⚠
- p.Pro1323Leu Single submitter ⚠
- p.Pro1324Leu Single submitter ⚠
- p.Pro574Leu Single submitter ⚠
- p.Pro628Leu Single submitter ⚠
- p.Pro629Ser Single submitter ⚠
- p.Pro631Ser Single submitter ⚠
- p.Pro681Leu Single submitter ⚠
- p.Pro681Ser Single submitter ⚠
- p.Pro683Ser Single submitter ⚠
- p.Pro711Ser Single submitter ⚠
- p.Pro743Leu Single submitter ⚠
- p.Pro796Thr Single submitter ⚠
- p.Pro806Leu Single submitter ⚠
- p.Pro840Leu Single submitter ⚠
- p.Pro841Ala Single submitter ⚠
- p.Pro848Thr Single submitter ⚠
- p.Pro849Leu Single submitter ⚠
- p.Pro864Leu Single submitter ⚠
- p.Pro880Thr Single submitter ⚠
- p.Pro889Leu Single submitter ⚠
- p.Pro948Ala Single submitter ⚠
- p.Thr580Ala Single submitter ⚠
- p.Val226Leu Single submitter ⚠
- p.Val291Ile Single submitter ⚠
- p.Val569Ile Single submitter ⚠