WDR36 — 301 ClinVar variants
All ClinVar germline WDR36 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 78 flagged for review →
2 Conflicting · 62 Benign · 13 Benign/Likely benign · 70 Likely benign · 154 Uncertain significance
Full WDR36 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 78
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 70
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- WDR36 p.Arg473Gln Uncertain significance Multiple submitters
- WDR36 p.Asn87Ser Uncertain significance Multiple submitters
-
WDR36 p.Asp571His
Uncertain significance
Multiple submitters
WDR36-related disorder
-
WDR36 p.Asp686Val
Uncertain significance
Multiple submitters
Glaucoma 1, open angle, G
-
WDR36 p.Gly282Arg
Uncertain significance
Multiple submitters
Glaucoma 1, open angle, G
- WDR36 p.Ala275Val Uncertain significance Single submitter
- WDR36 p.Arg230Cys Uncertain significance Single submitter
- WDR36 p.Arg230His Uncertain significance Single submitter
- WDR36 p.Asn570Ser Uncertain significance Single submitter
- WDR36 p.Asp298Asn Uncertain significance Single submitter
- WDR36 p.Asp437Asn Uncertain significance Single submitter
- WDR36 p.Asp438Gly Uncertain significance Single submitter
- WDR36 p.Asp577His Uncertain significance Single submitter
- WDR36 p.Asp602His Uncertain significance Single submitter
- WDR36 p.Asp668Gly Uncertain significance Single submitter
- WDR36 p.Asp70Asn Uncertain significance Single submitter
- WDR36 p.Asp833Val Uncertain significance Single submitter
- WDR36 p.Cys255Trp Uncertain significance Single submitter
- WDR36 p.Cys255Tyr Uncertain significance Single submitter
- WDR36 p.Cys449Phe Uncertain significance Single submitter
- WDR36 p.Cys810Phe Uncertain significance Single submitter
- WDR36 p.Gln480Arg Uncertain significance Single submitter
- WDR36 p.Gln566Pro Uncertain significance Single submitter
- WDR36 p.Gln568Arg Uncertain significance Single submitter
- WDR36 p.Gln56His Uncertain significance Single submitter
- WDR36 p.Gln69Arg Uncertain significance Single submitter
- WDR36 p.Glu138Asp Uncertain significance Single submitter
- WDR36 p.Glu800Ala Uncertain significance Single submitter
- WDR36 p.Gly308Arg Uncertain significance Single submitter
- WDR36 p.Gly425Asp Uncertain significance Single submitter
- WDR36 p.Gly567Asp Uncertain significance Single submitter
- WDR36 p.His100Arg Uncertain significance Single submitter
- WDR36 p.His364Tyr Uncertain significance Single submitter
- WDR36 p.His565Tyr Uncertain significance Single submitter
- WDR36 p.Ile127Thr Uncertain significance Single submitter
- WDR36 p.Ile405Val Uncertain significance Single submitter
- WDR36 p.Ile439Val Uncertain significance Single submitter
- WDR36 p.Ile529Ser Uncertain significance Single submitter
- WDR36 p.Ile529Thr Uncertain significance Single submitter
- WDR36 p.Leu173Val Uncertain significance Single submitter
- WDR36 p.Leu283Met Uncertain significance Single submitter
- WDR36 p.Leu507Val Uncertain significance Single submitter
- WDR36 p.Leu600Arg Uncertain significance Single submitter
- WDR36 p.Leu790Phe Uncertain significance Single submitter
- WDR36 p.Lys106Arg Uncertain significance Single submitter
- WDR36 p.Lys163Thr Uncertain significance Single submitter
- WDR36 p.Lys432Arg Uncertain significance Single submitter
- WDR36 p.Lys432Glu Uncertain significance Single submitter
- WDR36 p.Lys435Met Uncertain significance Single submitter
- WDR36 p.Lys891Thr Uncertain significance Single submitter
- WDR36 p.Met211Arg Uncertain significance Single submitter
- WDR36 p.Met467Ile Uncertain significance Single submitter
- WDR36 p.Met572Val Uncertain significance Single submitter
- WDR36 p.Met659Thr Uncertain significance Single submitter
- WDR36 p.Met659Val Uncertain significance Single submitter
- WDR36 p.Met827Val Uncertain significance Single submitter
- WDR36 p.Phe229Cys Uncertain significance Single submitter
- WDR36 p.Phe574Leu Uncertain significance Single submitter
- WDR36 p.Pro188Arg Uncertain significance Single submitter
- WDR36 p.Pro678Ser Uncertain significance Single submitter
- WDR36 p.Pro754Ser Uncertain significance Single submitter
- WDR36 p.Ser616Thr Uncertain significance Single submitter
- WDR36 p.Ser625Phe Uncertain significance Single submitter
- WDR36 p.Ser90Phe Uncertain significance Single submitter
- WDR36 p.Thr389Ser Uncertain significance Single submitter
- WDR36 p.Thr663Asn Uncertain significance Single submitter
- WDR36 p.Tyr685Cys Uncertain significance Single submitter
- WDR36 p.Val203Met Uncertain significance Single submitter
- WDR36 p.Val205Phe Uncertain significance Single submitter
- WDR36 p.Val669Ile Uncertain significance Single submitter
Predictors split 8
The independent predictors disagree with each other — read with care.
- WDR36 p.Ala542Thr Uncertain significance Single submitter
- WDR36 p.Arg804Gln Uncertain significance Single submitter
- WDR36 p.Glu723Ala Uncertain significance Single submitter
- WDR36 p.Ile455Thr Uncertain significance Single submitter
- WDR36 p.Lys726Arg Uncertain significance Single submitter
- WDR36 p.Lys726Thr Uncertain significance Single submitter
- WDR36 p.Phe318Leu Uncertain significance Single submitter
- WDR36 p.Ser253Asn Uncertain significance Single submitter
All WDR36 variants
Conflicting classifications of pathogenicity 2
- p.Asn299Ser Single submitter Glaucoma 1, open angle, G
- p.Ile548Val Single submitter OPTN-related open angle glaucoma
Benign 62
- c.163-7dup Multiple submitters
- c.1717-14T>A Multiple submitters
- c.1717-16T>A Multiple submitters
- c.1717-18T>A Multiple submitters
- c.1797-30A>G Multiple submitters Glaucoma 1, open angle, G
- c.2351-8T>G Multiple submitters
- c.543-31dup Multiple submitters Glaucoma 1, open angle, G
- p.Gly78= Multiple submitters
- p.Ile208Val Multiple submitters Glaucoma 1, open angle, G
- p.Met615Val Multiple submitters
- p.Tyr85= Multiple submitters
- p.Val658= Multiple submitters
- p.Val671= Multiple submitters Glaucoma 1, open angle, G
- c.1027+31T>G Single submitter
- c.1093+227C>G Single submitter
- c.1094-195T>C Single submitter
- c.1094-223G>A Single submitter
- c.1326+1111G>T Single submitter
- c.1326+143A>G Single submitter
- c.1326+309_1326+310insG Single submitter
- c.1326+309T>G Single submitter
- c.1441+89G>A Single submitter
- c.1442-22dup Single submitter
- c.1607+89C>A Single submitter
- c.163-264A>G Single submitter
- c.1716+235A>G Single submitter
- c.1717-21_1717-20insA Single submitter
- c.1717-23dup Single submitter
- c.1796+293dup Single submitter
- c.1797-179A>G Single submitter
- c.1797-321T>G Single submitter
- c.1904+138C>T Single submitter
- c.1905-295T>C Single submitter
- c.2003-186C>T Single submitter
- c.2003-18C>A Single submitter
- c.2148+256C>T Single submitter
- c.2148+319C>T Single submitter
- c.2149-199T>C Single submitter
- c.2350+60G>C Single submitter
- c.2351-23A>G Single submitter
- c.2351-246G>A Single submitter
- c.2351-75G>A Single submitter
- c.2538+129G>A Single submitter
- c.2538+189T>C Single submitter
- c.2538+199A>G Single submitter
- c.2539-202A>G Single submitter
- c.291+209A>G Single submitter
- c.291+221A>G Single submitter
- c.292-113G>A Single submitter
- c.292-127A>C Single submitter
- c.292-159T>G Single submitter
- c.410-150= Single submitter
- c.542+30C>T Single submitter Glaucoma 1, open angle, G
- c.543-215dup Single submitter
- c.597+259A>G Single submitter
- c.598-245G>A Single submitter
- c.907-78T>C Single submitter
- p.Arg242= Single submitter
- p.Asp492Asn Single submitter
- p.Leu605= Single submitter
- p.Lys508= Single submitter
- p.Pro688= Single submitter
Benign/Likely benign 13
- c.1717-10dup Multiple submitters
- c.1717-11_1717-10del Multiple submitters
- c.1717-20_1717-19insATATA Multiple submitters Glaucoma 1, open angle, G
- c.1717-20T>A Multiple submitters Glaucoma 1, open angle, G
- c.1717-22_1717-19del Multiple submitters
- c.2269-20T>C Multiple submitters
- c.907-18G>A Multiple submitters
- c.907-8C>G Multiple submitters
- p.Ala107Val Multiple submitters
- p.Ala393Thr Multiple submitters Usher syndrome type 2C
- p.Asp602Gly Multiple submitters
- p.Gln141= Multiple submitters
- p.Ser608= Multiple submitters
Likely benign 70
- c.1717-13_1717-10del Multiple submitters
- c.1717-14_1717-10dup Multiple submitters
- c.1717-19T>A Multiple submitters
- c.1717-21_1717-20insATATATT Multiple submitters
- c.1717-21_1717-20insATATTT Multiple submitters
- c.1717-21_1717-20insATT Multiple submitters
- c.1717-22A>T Multiple submitters
- c.731-39T>G Multiple submitters
- c.*93A>C Multiple submitters
- p.His156= Multiple submitters
- p.His156Pro Multiple submitters
- c.1027+87_1027+88insG Single submitter
- c.1028-12G>C Single submitter
- c.1028-18T>C Single submitter
- c.1028-8A>G Single submitter
- c.1093+200A>G Single submitter
- c.1094-20C>G Single submitter
- c.1181-215C>T Single submitter
- c.1326+266A>C Single submitter
- c.1716+11C>T Single submitter
- c.1716+183G>A Single submitter
- c.1717-10del Single submitter
- c.1717-12_1717-10del Single submitter
- c.1717-12_1717-10dup Single submitter
- c.1717-12T>A Single submitter
- c.1717-17_1717-10del Single submitter
- c.1717-20_1717-19insA Single submitter
- c.1717-20_1717-19insATA Single submitter
- c.1717-20_1717-19insATATATA Single submitter
- c.1717-20_1717-19insATATATATATATATA Single submitter
- c.1717-21_1717-20insATA Single submitter
- c.1717-21_1717-20insATATA Single submitter
- c.1717-21_1717-20insATATATATTTT Single submitter
- c.1717-21_1717-20insATATT Single submitter
- c.1717-21_1717-20insATATTTT Single submitter
- c.1717-21_1717-20insATTTT Single submitter
- c.1717-21_1717-20insATTTTT Single submitter
- c.1717-38AT[8] Single submitter
- c.1796+205A>G Single submitter
- c.1796+9A>G Single submitter
- c.1797-168T>C Single submitter
- c.1797-318C>T Single submitter
- c.1904+18G>A Single submitter
- c.2538+230T>C Single submitter
- c.2538+234G>A Single submitter
- c.2539-20C>G Single submitter
- c.291+19C>T Single submitter
- c.291+9C>T Single submitter
- c.292-19T>C Single submitter
- c.409+67A>G Single submitter
- c.410-19A>C Single submitter
- c.598-221C>G Single submitter
- c.731-20G>A Single submitter
- c.906+9A>G Single submitter
- c.906+9A>T Single submitter
- c.907-20A>G Single submitter
- c.*120A>G Single submitter
- p.Ala453= Single submitter
- p.Asn328Ser Single submitter
- p.Gly296= Single submitter
- p.Ile590Val Single submitter
- p.Leu286= Single submitter
- p.Pro853= Single submitter
- p.Ser866= Single submitter
- p.Thr353= Single submitter
- p.Thr786Ala Single submitter
- p.Val67Leu Single submitter
- c.2269-4T>C No assertion criteria WDR36-related disorder
- p.Arg314= No assertion criteria WDR36-related disorder
- p.Leu112= No assertion criteria WDR36-related disorder
Uncertain significance 154
- p.Ala297Ser Multiple submitters
- p.Ala75Thr Multiple submitters
- p.Arg374His Multiple submitters
- p.Arg473Gln Multiple submitters ⚠
- p.Asn87Ser Multiple submitters ⚠
- p.Asp571His Multiple submitters WDR36-related disorder ⚠
- p.Asp686Val Multiple submitters Glaucoma 1, open angle, G ⚠
- p.Glu674Gly Multiple submitters
- p.Glu684Gly Multiple submitters
- p.Gly282Arg Multiple submitters Glaucoma 1, open angle, G ⚠
- p.Ile553Met Multiple submitters
- p.Lys182Glu Multiple submitters Glaucoma 1, open angle, G
- p.Pro325Leu Multiple submitters
- c.46G>A Single submitter
- c.*1040_*1050del Single submitter
- p.Ala200Val Single submitter
- p.Ala275Val Single submitter ⚠
- p.Ala279Val Single submitter
- p.Ala443Thr Single submitter
- p.Ala490Thr Single submitter
- p.Ala542Thr Single submitter ⚠
- p.Ala585Val Single submitter
- p.Ala75Val Single submitter
- p.Ala766Thr Single submitter
- p.Ala837Val Single submitter
- p.Arg230Cys Single submitter ⚠
- p.Arg230His Single submitter ⚠
- p.Arg242His Single submitter
- p.Arg374Cys Single submitter
- p.Arg397His Single submitter
- p.Arg579Cys Single submitter
- p.Arg579His Single submitter
- p.Arg804Gln Single submitter ⚠
- p.Arg832His Single submitter
- p.Arg94Gly Single submitter
- p.Asn570Ser Single submitter ⚠
- p.Asn612Ser Single submitter
- p.Asn781Tyr Single submitter
- p.Asp232Val Single submitter
- p.Asp262Glu Single submitter
- p.Asp298Asn Single submitter ⚠
- p.Asp402Asn Single submitter
- p.Asp437Asn Single submitter ⚠
- p.Asp438Gly Single submitter ⚠
- p.Asp577His Single submitter ⚠
- p.Asp594Glu Single submitter
- p.Asp602His Single submitter ⚠
- p.Asp668Gly Single submitter ⚠
- p.Asp70Asn Single submitter ⚠
- p.Asp833Val Single submitter ⚠
- p.Cys255Trp Single submitter ⚠
- p.Cys255Tyr Single submitter ⚠
- p.Cys449Phe Single submitter ⚠
- p.Cys599Gly Single submitter
- p.Cys810Phe Single submitter ⚠
- p.Gln174Glu Single submitter
- p.Gln480Arg Single submitter ⚠
- p.Gln566Pro Single submitter ⚠
- p.Gln568Arg Single submitter ⚠
- p.Gln56His Single submitter ⚠
- p.Gln69Arg Single submitter ⚠
- p.Gln756Arg Single submitter
- p.Glu138Asp Single submitter ⚠
- p.Glu693Gln Single submitter
- p.Glu723Ala Single submitter ⚠
- p.Glu800Ala Single submitter ⚠
- p.Gly104Ser Single submitter
- p.Gly245Asp Single submitter
- p.Gly308Arg Single submitter ⚠
- p.Gly403Val Single submitter
- p.Gly410Asp Single submitter
- p.Gly425Asp Single submitter ⚠
- p.Gly474Ala Single submitter
- p.Gly567Asp Single submitter ⚠
- p.Gly598Ala Single submitter
- p.His100Arg Single submitter ⚠
- p.His118Asn Single submitter
- p.His218Tyr Single submitter
- p.His257Arg Single submitter
- p.His257Tyr Single submitter
- p.His364Tyr Single submitter ⚠
- p.His565Tyr Single submitter ⚠
- p.Ile109Met Single submitter
- p.Ile127Thr Single submitter ⚠
- p.Ile258Thr Single submitter
- p.Ile405Val Single submitter ⚠
- p.Ile439Val Single submitter ⚠
- p.Ile455Thr Single submitter ⚠
- p.Ile529Ser Single submitter ⚠
- p.Ile529Thr Single submitter ⚠
- p.Leu173Val Single submitter ⚠
- p.Leu283Met Single submitter ⚠
- p.Leu315Ile Single submitter
- p.Leu326Pro Single submitter
- p.Leu497Ser Single submitter
- p.Leu507Val Single submitter ⚠
- p.Leu600Arg Single submitter ⚠
- p.Leu649Phe Single submitter
- p.Leu790Phe Single submitter ⚠
- p.Leu803Met Single submitter
- p.Leu828Gln Single submitter
- p.Lys106Arg Single submitter ⚠
- p.Lys163Thr Single submitter ⚠
- p.Lys221Gln Single submitter
- p.Lys360Gln Single submitter
- p.Lys432Arg Single submitter ⚠
- p.Lys432Glu Single submitter ⚠
- p.Lys435Met Single submitter ⚠
- p.Lys726Arg Single submitter ⚠
- p.Lys726Thr Single submitter ⚠
- p.Lys891Thr Single submitter ⚠
- p.Met211Arg Single submitter ⚠
- p.Met467Ile Single submitter ⚠
- p.Met572Val Single submitter ⚠
- p.Met615fs Single submitter
- p.Met659Thr Single submitter ⚠
- p.Met659Val Single submitter ⚠
- p.Met827Val Single submitter ⚠
- p.Phe187Ile Single submitter
- p.Phe229Cys Single submitter ⚠
- p.Phe318Leu Single submitter ⚠
- p.Phe562Leu Single submitter
- p.Phe574Leu Single submitter ⚠
- p.Phe771Tyr Single submitter
- p.Phe820Tyr Single submitter
- p.Phe82Ile Single submitter
- p.Pro114Leu Single submitter
- p.Pro188Arg Single submitter ⚠
- p.Pro386Gln Single submitter
- p.Pro527Ala Single submitter
- p.Pro678Ser Single submitter ⚠
- p.Pro754Ser Single submitter ⚠
- p.Pro856Thr Single submitter
- p.Ser172Arg Single submitter
- p.Ser253Asn Single submitter ⚠
- p.Ser547Cys Single submitter
- p.Ser589Cys Single submitter
- p.Ser608Leu Single submitter
- p.Ser616Thr Single submitter ⚠
- p.Ser625Phe Single submitter ⚠
- p.Ser807Phe Single submitter
- p.Ser878Pro Single submitter
- p.Ser90Phe Single submitter ⚠
- p.Thr389Arg Single submitter
- p.Thr389Ser Single submitter ⚠
- p.Thr624Ala Single submitter
- p.Thr663Asn Single submitter ⚠
- p.Trp190Ser Single submitter
- p.Trp233Ter Single submitter
- p.Tyr685Cys Single submitter ⚠
- p.Val203Met Single submitter ⚠
- p.Val205Phe Single submitter ⚠
- p.Val444Ala Single submitter
- p.Val669Ile Single submitter ⚠