WDR77 — 36 ClinVar variants
All ClinVar germline WDR77 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 34 flagged for review →
2 Likely benign · 34 Uncertain significance
Full WDR77 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 34
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 31
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- WDR77 p.Ala13Val Uncertain significance Single submitter
- WDR77 p.Ala210Val Uncertain significance Single submitter
- WDR77 p.Ala338Thr Uncertain significance Single submitter
- WDR77 p.Arg29Gln Uncertain significance Single submitter
- WDR77 p.Asn69Asp Uncertain significance Single submitter
- WDR77 p.Asp109Gly Uncertain significance Single submitter
- WDR77 p.Cys199Arg Uncertain significance Single submitter
- WDR77 p.Glu289Gln Uncertain significance Single submitter
- WDR77 p.Gly45Arg Uncertain significance Single submitter
- WDR77 p.His266Tyr Uncertain significance Single submitter
- WDR77 p.His325Asp Uncertain significance Single submitter
- WDR77 p.Ile127Val Uncertain significance Single submitter
- WDR77 p.Leu108Val Uncertain significance Single submitter
- WDR77 p.Leu271Val Uncertain significance Single submitter
- WDR77 p.Leu332Phe Uncertain significance Single submitter
- WDR77 p.Leu60Phe Uncertain significance Single submitter
- WDR77 p.Leu9Arg Uncertain significance Single submitter
- WDR77 p.Pro200Ser Uncertain significance Single submitter
- WDR77 p.Pro21Gln Uncertain significance Single submitter
- WDR77 p.Pro265Ala Uncertain significance Single submitter
- WDR77 p.Pro331Leu Uncertain significance Single submitter
- WDR77 p.Pro6Arg Uncertain significance Single submitter
- WDR77 p.Pro8His Uncertain significance Single submitter
- WDR77 p.Pro8Leu Uncertain significance Single submitter
- WDR77 p.Ser339Asn Uncertain significance Single submitter
- WDR77 p.Val158Ala Uncertain significance Single submitter
- WDR77 p.Val158Leu Uncertain significance Single submitter
- WDR77 p.Val182Met Uncertain significance Single submitter
- WDR77 p.Val237Ile Uncertain significance Single submitter
- WDR77 p.Val240Leu Uncertain significance Single submitter
- WDR77 p.Val248Ile Uncertain significance Single submitter
Predictors split 3
The independent predictors disagree with each other — read with care.
All WDR77 variants
Likely benign 2
- p.Ala210= Single submitter
- p.Val326Ile Single submitter
Uncertain significance 34
- p.Ala13Val Single submitter ⚠
- p.Ala210Val Single submitter ⚠
- p.Ala338Thr Single submitter ⚠
- p.Arg29Gln Single submitter ⚠
- p.Asn69Asp Single submitter ⚠
- p.Asp109Gly Single submitter ⚠
- p.Cys199Arg Single submitter ⚠
- p.Glu289Gln Single submitter ⚠
- p.Glu70Lys Single submitter ⚠
- p.Gly45Arg Single submitter ⚠
- p.Gly76Arg Single submitter ⚠
- p.His266Tyr Single submitter ⚠
- p.His325Asp Single submitter ⚠
- p.Ile127Val Single submitter ⚠
- p.Leu108Val Single submitter ⚠
- p.Leu271Val Single submitter ⚠
- p.Leu332Phe Single submitter ⚠
- p.Leu60Phe Single submitter ⚠
- p.Leu9Arg Single submitter ⚠
- p.Pro200Ser Single submitter ⚠
- p.Pro21Gln Single submitter ⚠
- p.Pro265Ala Single submitter ⚠
- p.Pro331Leu Single submitter ⚠
- p.Pro64Leu Single submitter ⚠
- p.Pro6Arg Single submitter ⚠
- p.Pro8His Single submitter ⚠
- p.Pro8Leu Single submitter ⚠
- p.Ser339Asn Single submitter ⚠
- p.Val158Ala Single submitter ⚠
- p.Val158Leu Single submitter ⚠
- p.Val182Met Single submitter ⚠
- p.Val237Ile Single submitter ⚠
- p.Val240Leu Single submitter ⚠
- p.Val248Ile Single submitter ⚠