WDR82 — 15 ClinVar variants
All ClinVar germline WDR82 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 12 flagged for review →
1 Likely benign · 14 Uncertain significance
Full WDR82 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 12
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 6
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- WDR82 p.Asn204Ser Uncertain significance Single submitter
- WDR82 p.Gln252Arg Uncertain significance Single submitter
- WDR82 p.Gly215Ser Uncertain significance Single submitter
- WDR82 p.Ile221Met Uncertain significance Single submitter
- WDR82 p.Ile89Val Uncertain significance Single submitter
- WDR82 p.Lys262Arg Uncertain significance Single submitter
Predictors split 6
The independent predictors disagree with each other — read with care.
- WDR82 p.Asn20Ser Uncertain significance Single submitter
- WDR82 p.Asp28Asn Uncertain significance Single submitter
- WDR82 p.Asp87Glu Uncertain significance Single submitter
- WDR82 p.Cys195Phe Uncertain significance Single submitter
- WDR82 p.Glu169Gln Uncertain significance Single submitter
- WDR82 p.Lys129Asn Uncertain significance Single submitter
All WDR82 variants
Likely benign 1
- p.Arg109= Single submitter
Uncertain significance 14
- p.Asn204Ser Single submitter ⚠
- p.Asn20Ser Single submitter ⚠
- p.Asp28Asn Single submitter ⚠
- p.Asp87Glu Single submitter ⚠
- p.Cys195Phe Single submitter ⚠
- p.Gln252Arg Single submitter ⚠
- p.Glu169Gln Single submitter ⚠
- p.Gly215Ser Single submitter ⚠
- p.Ile221Met Single submitter ⚠
- p.Ile89Val Single submitter ⚠
- p.Lys129Asn Single submitter ⚠
- p.Lys262Arg Single submitter ⚠
- p.Met295Val Single submitter
- p.Thr77fs Single submitter