WEE1 — 66 ClinVar variants
All ClinVar germline WEE1 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 62 flagged for review →
1 Benign · 65 Uncertain significance
Full WEE1 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 62
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 51
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- WEE1 p.Ala130Val Uncertain significance Single submitter
- WEE1 p.Ala156Thr Uncertain significance Single submitter
- WEE1 p.Ala15Ser Uncertain significance Single submitter
- WEE1 p.Ala510Thr Uncertain significance Single submitter
- WEE1 p.Arg13Cys Uncertain significance Single submitter
- WEE1 p.Arg223Gly Uncertain significance Single submitter
- WEE1 p.Arg436Gln Uncertain significance Single submitter
- WEE1 p.Arg628Thr Uncertain significance Single submitter
- WEE1 p.Arg66Trp Uncertain significance Single submitter
- WEE1 p.Arg75Cys Uncertain significance Single submitter
- WEE1 p.Asp448Gly Uncertain significance Single submitter
- WEE1 p.Asp451Tyr Uncertain significance Single submitter
- WEE1 p.Asp616Glu Uncertain significance Single submitter
- WEE1 p.Gln232Leu Uncertain significance Single submitter
- WEE1 p.Gln528Arg Uncertain significance Single submitter
- WEE1 p.Gln540Glu Uncertain significance Single submitter
- WEE1 p.Glu275Lys Uncertain significance Single submitter
- WEE1 p.Glu541Lys Uncertain significance Single submitter
- WEE1 p.Gly145Asp Uncertain significance Single submitter
- WEE1 p.Gly153Ala Uncertain significance Single submitter
- WEE1 p.Gly155Ala Uncertain significance Single submitter
- WEE1 p.Gly447Ala Uncertain significance Single submitter
- WEE1 p.Gly44Ser Uncertain significance Single submitter
- WEE1 p.His189Leu Uncertain significance Single submitter
- WEE1 p.Ile26Leu Uncertain significance Single submitter
- WEE1 p.Ile388Thr Uncertain significance Single submitter
- WEE1 p.Ile434Val Uncertain significance Single submitter
- WEE1 p.Lys192Arg Uncertain significance Single submitter
- WEE1 p.Lys547Thr Uncertain significance Single submitter
- WEE1 p.Met215Leu Uncertain significance Single submitter
- WEE1 p.Phe225Leu Uncertain significance Single submitter
- WEE1 p.Pro140Leu Uncertain significance Single submitter
- WEE1 p.Pro81Leu Uncertain significance Single submitter
- WEE1 p.Pro81Thr Uncertain significance Single submitter
- WEE1 p.Ser121Cys Uncertain significance Single submitter
- WEE1 p.Ser165Trp Uncertain significance Single submitter
- WEE1 p.Ser5Gly Uncertain significance Single submitter
- WEE1 p.Ser60Leu Uncertain significance Single submitter
- WEE1 p.Ser626Ile Uncertain significance Single submitter
- WEE1 p.Ser630Thr Uncertain significance Single submitter
- WEE1 p.Ser78Ala Uncertain significance Single submitter
- WEE1 p.Ser85Arg Uncertain significance Single submitter
- WEE1 p.Thr20Ala Uncertain significance Single submitter
- WEE1 p.Thr20Ile Uncertain significance Single submitter
- WEE1 p.Thr615Ile Uncertain significance Single submitter
- WEE1 p.Thr69Ala Uncertain significance Single submitter
- WEE1 p.Thr69Pro Uncertain significance Single submitter
- WEE1 p.Tyr378Cys Uncertain significance Single submitter
- WEE1 p.Val206Phe Uncertain significance Single submitter
- WEE1 p.Val338Ile Uncertain significance Single submitter
- WEE1 p.Val457Ile Uncertain significance Single submitter
Predictors split 11
The independent predictors disagree with each other — read with care.
- WEE1 p.Ala387Ser Uncertain significance Single submitter
- WEE1 p.Arg533Trp Uncertain significance Single submitter
- WEE1 p.Cys509Arg Uncertain significance Single submitter
- WEE1 p.Glu309Ala Uncertain significance Single submitter
- WEE1 p.Glu36Val Uncertain significance Single submitter
- WEE1 p.Ile434Leu Uncertain significance Single submitter
- WEE1 p.Ile434Met Uncertain significance Single submitter
- WEE1 p.Phe589Leu Uncertain significance Single submitter
- WEE1 p.Pro175Ser Uncertain significance Single submitter
- WEE1 p.Pro517Ala Uncertain significance Single submitter
- WEE1 p.Thr190Ser Uncertain significance Single submitter
All WEE1 variants
Benign 1
- p.Gly210Cys Multiple submitters
Uncertain significance 65
- p.Ala130Val Single submitter ⚠
- p.Ala156Thr Single submitter ⚠
- p.Ala15Ser Single submitter ⚠
- p.Ala387Ser Single submitter ⚠
- p.Ala510Thr Single submitter ⚠
- p.Arg13Cys Single submitter ⚠
- p.Arg223Gly Single submitter ⚠
- p.Arg436Gln Single submitter ⚠
- p.Arg533Trp Single submitter ⚠
- p.Arg617Trp Single submitter
- p.Arg621Trp Single submitter
- p.Arg628Thr Single submitter ⚠
- p.Arg66Trp Single submitter ⚠
- p.Arg75Cys Single submitter ⚠
- p.Asp448Gly Single submitter ⚠
- p.Asp451Tyr Single submitter ⚠
- p.Asp616Glu Single submitter ⚠
- p.Cys509Arg Single submitter ⚠
- p.Gln232Leu Single submitter ⚠
- p.Gln528Arg Single submitter ⚠
- p.Gln540Glu Single submitter ⚠
- p.Glu275Lys Single submitter ⚠
- p.Glu309Ala Single submitter ⚠
- p.Glu36Val Single submitter ⚠
- p.Glu541Lys Single submitter ⚠
- p.Gly145Asp Single submitter ⚠
- p.Gly153Ala Single submitter ⚠
- p.Gly155Ala Single submitter ⚠
- p.Gly447Ala Single submitter ⚠
- p.Gly44Ser Single submitter ⚠
- p.His189Leu Single submitter ⚠
- p.Ile26Leu Single submitter ⚠
- p.Ile388Thr Single submitter ⚠
- p.Ile434Leu Single submitter ⚠
- p.Ile434Met Single submitter ⚠
- p.Ile434Val Single submitter ⚠
- p.Lys192Arg Single submitter ⚠
- p.Lys547Thr Single submitter ⚠
- p.Met215Leu Single submitter ⚠
- p.Phe225Leu Single submitter ⚠
- p.Phe589Leu Single submitter ⚠
- p.Pro140Leu Single submitter ⚠
- p.Pro175Ser Single submitter ⚠
- p.Pro517Ala Single submitter ⚠
- p.Pro81Leu Single submitter ⚠
- p.Pro81Thr Single submitter ⚠
- p.Ser121Cys Single submitter ⚠
- p.Ser165Trp Single submitter ⚠
- p.Ser421Phe Single submitter
- p.Ser5Gly Single submitter ⚠
- p.Ser60Leu Single submitter ⚠
- p.Ser626Ile Single submitter ⚠
- p.Ser630Thr Single submitter ⚠
- p.Ser78Ala Single submitter ⚠
- p.Ser85Arg Single submitter ⚠
- p.Thr190Ser Single submitter ⚠
- p.Thr20Ala Single submitter ⚠
- p.Thr20Ile Single submitter ⚠
- p.Thr615Ile Single submitter ⚠
- p.Thr69Ala Single submitter ⚠
- p.Thr69Pro Single submitter ⚠
- p.Tyr378Cys Single submitter ⚠
- p.Val206Phe Single submitter ⚠
- p.Val338Ile Single submitter ⚠
- p.Val457Ile Single submitter ⚠