WEE2 — 102 ClinVar variants
All ClinVar germline WEE2 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 72 flagged for review →
7 Pathogenic · 1 Pathogenic/Likely pathogenic · 1 Conflicting · 3 Benign · 1 Benign/Likely benign · 15 Likely benign · 74 Uncertain significance
Full WEE2 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 72
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors vs ClinVar 1
ClinVar calls these pathogenic, but the computational predictors lean tolerated — the highest-value review flag.
-
WEE2 p.Arg410Trp
Pathogenic
No assertion criteria
oocyte maturation defect 5
Predictors lean, ClinVar uncertain 63
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- WEE2 p.Gly357Arg Uncertain significance Multiple submitters
- WEE2 p.Ala194Asp Uncertain significance Single submitter
- WEE2 p.Ala300Val Uncertain significance Single submitter
- WEE2 p.Ala384Thr Uncertain significance Single submitter
- WEE2 p.Ala96Val Uncertain significance Single submitter
- WEE2 p.Arg200Gln Uncertain significance Single submitter
- WEE2 p.Arg207His Uncertain significance Single submitter
- WEE2 p.Arg232Lys Uncertain significance Single submitter
- WEE2 p.Arg444Cys Uncertain significance Single submitter
- WEE2 p.Arg444His Uncertain significance Single submitter
- WEE2 p.Arg487Trp Uncertain significance Single submitter
- WEE2 p.Arg542Ser Uncertain significance Single submitter
- WEE2 p.Arg546His Uncertain significance Single submitter
- WEE2 p.Arg563Cys Uncertain significance Single submitter
- WEE2 p.Cys91Arg Uncertain significance Single submitter
- WEE2 p.Gln519Glu Uncertain significance Single submitter
- WEE2 p.Glu182Gln Uncertain significance Single submitter
- WEE2 p.Glu201Gly Uncertain significance Single submitter
- WEE2 p.Glu209Lys Uncertain significance Single submitter
- WEE2 p.Glu21Val Uncertain significance Single submitter
- WEE2 p.Glu23Asp Uncertain significance Single submitter
- WEE2 p.Glu281Asp Uncertain significance Single submitter
- WEE2 p.Glu35Gln Uncertain significance Single submitter
- WEE2 p.Glu454Gln Uncertain significance Single submitter
- WEE2 p.Glu472Gln Uncertain significance Single submitter
- WEE2 p.Glu472Lys Uncertain significance Single submitter
- WEE2 p.Glu562Gly Uncertain significance Single submitter
- WEE2 p.Glu93Gln Uncertain significance Single submitter
- WEE2 p.Gly171Ala Uncertain significance Single submitter
- WEE2 p.Gly191Arg Uncertain significance Single submitter
- WEE2 p.Gly379Asp Uncertain significance Single submitter
- WEE2 p.Gly446Ser Uncertain significance Single submitter
- WEE2 p.Gly525Val Uncertain significance Single submitter
- WEE2 p.His310Asn Uncertain significance Single submitter
- WEE2 p.His349Tyr Uncertain significance Single submitter
- WEE2 p.Ile155Val Uncertain significance Single submitter
- WEE2 p.Ile240Thr Uncertain significance Single submitter
- WEE2 p.Leu325His Uncertain significance Single submitter
- WEE2 p.Leu486Val Uncertain significance Single submitter
- WEE2 p.Leu510Pro Uncertain significance Single submitter
- WEE2 p.Lys114Glu Uncertain significance Single submitter
- WEE2 p.Lys189Asn Uncertain significance Single submitter
- WEE2 p.Lys350Arg Uncertain significance Single submitter
- WEE2 p.Lys545Glu Uncertain significance Single submitter
- WEE2 p.Lys74Glu Uncertain significance Single submitter
- WEE2 p.Met351Leu Uncertain significance Single submitter
- WEE2 p.Met466Thr Uncertain significance Single submitter
- WEE2 p.Phe369Ser Uncertain significance Single submitter
- WEE2 p.Phe459Ser Uncertain significance Single submitter
- WEE2 p.Pro314Arg Uncertain significance Single submitter
- WEE2 p.Pro413Ala Uncertain significance Single submitter
- WEE2 p.Pro523Thr Uncertain significance Single submitter
- WEE2 p.Pro55Ser Uncertain significance Single submitter
- WEE2 p.Ser307Cys Uncertain significance Single submitter
- WEE2 p.Ser543Thr Uncertain significance Single submitter
- WEE2 p.Ser70Leu Uncertain significance Single submitter
- WEE2 p.Thr509Arg Uncertain significance Single submitter
- WEE2 p.Thr54Ser Uncertain significance Single submitter
- WEE2 p.Thr559Ser Uncertain significance Single submitter
-
WEE2 p.Tyr163His
Uncertain significance
Single submitter
oocyte maturation defect 5
- WEE2 p.Tyr18His Uncertain significance Single submitter
- WEE2 p.Tyr276Cys Uncertain significance Single submitter
- WEE2 p.Val63Met Uncertain significance Single submitter
Predictors split 8
The independent predictors disagree with each other — read with care.
- WEE2 p.Ala427Thr Uncertain significance Single submitter
- WEE2 p.Arg119Trp Uncertain significance Single submitter
- WEE2 p.Arg242Cys Uncertain significance Single submitter
- WEE2 p.Arg242His Uncertain significance Single submitter
- WEE2 p.Arg274Cys Uncertain significance Single submitter
- WEE2 p.Asn483Lys Uncertain significance Single submitter
- WEE2 p.His442Pro Uncertain significance Single submitter
- WEE2 p.Met335Thr Uncertain significance Single submitter
All WEE2 variants
Pathogenic 7
- p.Gln288Ter Single submitter
- p.His337fs Single submitter oocyte maturation defect 5
- p.Arg200Ter No assertion criteria oocyte maturation defect 5
- p.Arg410Trp No assertion criteria oocyte maturation defect 5 ⚠
- p.Asp234His No assertion criteria oocyte maturation defect 5
- p.Glu407= No assertion criteria oocyte maturation defect 5
- p.Thr493fs No assertion criteria oocyte maturation defect 5
Pathogenic/Likely pathogenic 1
- p.Glu75fs Multiple submitters WEE2-related disorder
Conflicting classifications of pathogenicity 1
- p.Asp450= Single submitter
Benign 3
- c.881-8T>C Multiple submitters
- p.Gly171= Single submitter
- p.Ala264= No assertion criteria WEE2-related disorder
Benign/Likely benign 1
- p.Tyr526Asp Multiple submitters
Likely benign 15
- c.540-11dup Single submitter
- p.Arg410Gln Single submitter
- p.Arg563His Single submitter
- p.Ile176Thr Single submitter
- p.Lys245= Single submitter
- p.Lys43Arg Single submitter
- p.Phe448Leu Single submitter
- p.Ser255Leu Single submitter
- p.Ser37Leu Single submitter
- p.Ser70= Single submitter
- p.Val451Ile Single submitter
- c.1536-9G>A No assertion criteria WEE2-related disorder
- p.Asn62= No assertion criteria WEE2-related disorder
- p.Lys134= No assertion criteria WEE2-related disorder
- p.Ser100= No assertion criteria WEE2-related disorder
Uncertain significance 74
- p.Gly357Arg Multiple submitters ⚠
- p.Ile417Thr Multiple submitters
- c.585+3A>G Single submitter
- p.Ala194Asp Single submitter ⚠
- p.Ala300Val Single submitter ⚠
- p.Ala384Thr Single submitter ⚠
- p.Ala427Thr Single submitter ⚠
- p.Ala96Val Single submitter ⚠
- p.Arg119Trp Single submitter ⚠
- p.Arg200Gln Single submitter ⚠
- p.Arg207His Single submitter ⚠
- p.Arg232Lys Single submitter ⚠
- p.Arg242Cys Single submitter ⚠
- p.Arg242His Single submitter ⚠
- p.Arg274Cys Single submitter ⚠
- p.Arg444Cys Single submitter ⚠
- p.Arg444His Single submitter ⚠
- p.Arg487Trp Single submitter ⚠
- p.Arg542Ser Single submitter ⚠
- p.Arg546His Single submitter ⚠
- p.Arg563Cys Single submitter ⚠
- p.Asn483Lys Single submitter ⚠
- p.Cys91Arg Single submitter ⚠
- p.Gln519Glu Single submitter ⚠
- p.Glu182Gln Single submitter ⚠
- p.Glu201Gly Single submitter ⚠
- p.Glu209Lys Single submitter ⚠
- p.Glu21Val Single submitter ⚠
- p.Glu23Asp Single submitter ⚠
- p.Glu281Asp Single submitter ⚠
- p.Glu35Gln Single submitter ⚠
- p.Glu454Gln Single submitter ⚠
- p.Glu472Gln Single submitter ⚠
- p.Glu472Lys Single submitter ⚠
- p.Glu562Gly Single submitter ⚠
- p.Glu93Gln Single submitter ⚠
- p.Gly171Ala Single submitter ⚠
- p.Gly191Arg Single submitter ⚠
- p.Gly379Asp Single submitter ⚠
- p.Gly446Ser Single submitter ⚠
- p.Gly525Val Single submitter ⚠
- p.His310Asn Single submitter ⚠
- p.His349Tyr Single submitter ⚠
- p.His442Pro Single submitter ⚠
- p.Ile155Val Single submitter ⚠
- p.Ile240Thr Single submitter ⚠
- p.Leu325His Single submitter ⚠
- p.Leu486Val Single submitter ⚠
- p.Leu510Pro Single submitter ⚠
- p.Lys114Glu Single submitter ⚠
- p.Lys189Asn Single submitter ⚠
- p.Lys350Arg Single submitter ⚠
- p.Lys545Glu Single submitter ⚠
- p.Lys74Glu Single submitter ⚠
- p.Met335Thr Single submitter ⚠
- p.Met351Leu Single submitter ⚠
- p.Met466Thr Single submitter ⚠
- p.Phe369Ser Single submitter ⚠
- p.Phe459Ser Single submitter ⚠
- p.Pro314Arg Single submitter ⚠
- p.Pro413Ala Single submitter ⚠
- p.Pro523Thr Single submitter ⚠
- p.Pro55Ser Single submitter ⚠
- p.Ser307Cys Single submitter ⚠
- p.Ser543Thr Single submitter ⚠
- p.Ser70Leu Single submitter ⚠
- p.Thr509Arg Single submitter ⚠
- p.Thr54Ser Single submitter ⚠
- p.Thr559Ser Single submitter ⚠
- p.Tyr163His Single submitter oocyte maturation defect 5 ⚠
- p.Tyr18His Single submitter ⚠
- p.Tyr276Cys Single submitter ⚠
- p.Tyr291His Single submitter
- p.Val63Met Single submitter ⚠