WHR1 — 35 ClinVar variants
All ClinVar germline WHR1 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 28 flagged for review →
3 Likely benign · 32 Uncertain significance
Full WHR1 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 28
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 27
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- WHR1 c.-30C>G Uncertain significance Single submitter
- WHR1 c.-3G>A Uncertain significance Single submitter
- WHR1 c.-5G>T Uncertain significance Single submitter
- WHR1 p.Ala115Ser Uncertain significance Single submitter
- WHR1 p.Ala36Ser Uncertain significance Single submitter
- WHR1 p.Ala36Val Uncertain significance Single submitter
- WHR1 p.Arg119Gln Uncertain significance Single submitter
- WHR1 p.Arg205Gln Uncertain significance Single submitter
- WHR1 p.Arg216Trp Uncertain significance Single submitter
- WHR1 p.Arg222Gln Uncertain significance Single submitter
- WHR1 p.Arg67Pro Uncertain significance Single submitter
- WHR1 p.Asp27Glu Uncertain significance Single submitter
- WHR1 p.Glu106Gly Uncertain significance Single submitter
- WHR1 p.Glu11Asp Uncertain significance Single submitter
- WHR1 p.Glu79Gly Uncertain significance Single submitter
- WHR1 p.Leu133Phe Uncertain significance Single submitter
- WHR1 p.Phe13Ser Uncertain significance Single submitter
- WHR1 p.Pro28Leu Uncertain significance Single submitter
- WHR1 p.Pro50Ala Uncertain significance Single submitter
- WHR1 p.Pro59Ala Uncertain significance Single submitter
- WHR1 p.Pro77Arg Uncertain significance Single submitter
- WHR1 p.Ser2Gly Uncertain significance Single submitter
- WHR1 p.Ser35Trp Uncertain significance Single submitter
- WHR1 p.Thr31Met Uncertain significance Single submitter
- WHR1 p.Thr80Ser Uncertain significance Single submitter
- WHR1 p.Trp56Gly Uncertain significance Single submitter
- WHR1 p.Val38Met Uncertain significance Single submitter
Predictors split 1
The independent predictors disagree with each other — read with care.
All WHR1 variants
Likely benign 3
- p.Ala217Val Single submitter
- p.Ala42Val Single submitter
- p.Val91Ile Single submitter
Uncertain significance 32
- c.-30C>G Single submitter ⚠
- c.-3G>A Single submitter ⚠
- c.-5G>T Single submitter ⚠
- p.Ala115Ser Single submitter ⚠
- p.Ala36Ser Single submitter ⚠
- p.Ala36Val Single submitter ⚠
- p.Arg119Gln Single submitter ⚠
- p.Arg205Gln Single submitter ⚠
- p.Arg215Gln Single submitter
- p.Arg216Trp Single submitter ⚠
- p.Arg222Gln Single submitter ⚠
- p.Arg67Pro Single submitter ⚠
- p.Asp27Glu Single submitter ⚠
- p.Asp96Asn Single submitter
- p.Glu106Gly Single submitter ⚠
- p.Glu11Asp Single submitter ⚠
- p.Glu79Gly Single submitter ⚠
- p.Ile233Thr Single submitter
- p.Leu133Phe Single submitter ⚠
- p.Met146Ile Single submitter ⚠
- p.Phe13Ser Single submitter ⚠
- p.Pro28Leu Single submitter ⚠
- p.Pro50Ala Single submitter ⚠
- p.Pro59Ala Single submitter ⚠
- p.Pro77Arg Single submitter ⚠
- p.Ser2Gly Single submitter ⚠
- p.Ser35Trp Single submitter ⚠
- p.Thr31Met Single submitter ⚠
- p.Thr80Ser Single submitter ⚠
- p.Trp56Gly Single submitter ⚠
- p.Tyr108Cys Single submitter
- p.Val38Met Single submitter ⚠