WNT10A — 561 ClinVar variants

All ClinVar germline WNT10A variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 188 flagged for review →

56 Pathogenic · 24 Pathogenic/Likely pathogenic · 26 Likely pathogenic · 39 Conflicting · 2 Benign · 5 Benign/Likely benign · 230 Likely benign · 179 Uncertain significance

Full WNT10A gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions

⚑ Evidence disagreements 188

Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.

Predictors vs ClinVar 1

ClinVar calls these pathogenic, but the computational predictors lean tolerated — the highest-value review flag.

WNT10A p.Arg128Gln Pathogenic/Likely pathogenic Multiple submitters
tooth agenesis, selective, 4

Predictors agree, ClinVar conflicts 24

ClinVar submitters conflict, but the independent predictors unanimously agree — a QC review flag, not a reclassification.

WNT10A p.Ala135Thr Conflicting Single submitter
odonto-onycho-dermal dysplasia
WNT10A p.Ala21Gly Conflicting Single submitter
tooth agenesis, selective, 4
WNT10A p.Arg104His Conflicting Single submitter
tooth agenesis, selective, 4
WNT10A p.Arg113Cys Conflicting Single submitter
odonto-onycho-dermal dysplasia
WNT10A p.Arg171Cys Conflicting Single submitter
odonto-onycho-dermal dysplasia
WNT10A p.Arg171His Conflicting Single submitter
odonto-onycho-dermal dysplasia
WNT10A p.Arg184His Conflicting Single submitter
Schöpf-Schulz-Passarge syndrome
WNT10A p.Arg360Leu Conflicting Single submitter
tooth agenesis, selective, 4
WNT10A p.Asn106Lys Conflicting Single submitter
odonto-onycho-dermal dysplasia
WNT10A p.Asn363His Conflicting Single submitter
odonto-onycho-dermal dysplasia
WNT10A p.Asp217Asn Conflicting Single submitter
odonto-onycho-dermal dysplasia
WNT10A p.Asp217Gly Conflicting Single submitter
odonto-onycho-dermal dysplasia
WNT10A p.Cys372Gly Conflicting Single submitter
odonto-onycho-dermal dysplasia
WNT10A p.Cys400Ser Conflicting Single submitter
odonto-onycho-dermal dysplasia
WNT10A p.Gly165Arg Conflicting Single submitter
odonto-onycho-dermal dysplasia
WNT10A p.Gly213Ser Conflicting Single submitter
odonto-onycho-dermal dysplasia
WNT10A p.Gly221Arg Conflicting Single submitter
odonto-onycho-dermal dysplasia
WNT10A p.Gly266Ser Conflicting Single submitter
odonto-onycho-dermal dysplasia
WNT10A p.Ile136Met Conflicting Single submitter
odonto-onycho-dermal dysplasia
WNT10A p.Met218Val Conflicting Single submitter
tooth agenesis, selective, 4
WNT10A p.Phe345Ser Conflicting Single submitter
tooth agenesis, selective, 4
WNT10A p.Pro50Leu Conflicting Single submitter
ectodermal dysplasia WNT10A related
WNT10A p.Ser270Arg Conflicting Single submitter
tooth agenesis, selective, 4
WNT10A p.Trp277Cys Conflicting Single submitter
odonto-onycho-dermal dysplasia

Predictors lean, ClinVar uncertain 125

ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.

WNT10A p.Ala148Val Uncertain significance Multiple submitters
odonto-onycho-dermal dysplasia
WNT10A p.Ala288Thr Uncertain significance Multiple submitters
Inborn genetic diseases
WNT10A p.Ala92Val Uncertain significance Multiple submitters
odonto-onycho-dermal dysplasia
WNT10A p.Arg13Pro Uncertain significance Multiple submitters
Inborn genetic diseases
WNT10A p.Arg223Cys Uncertain significance Multiple submitters
odonto-onycho-dermal dysplasia
WNT10A p.Arg223His Uncertain significance Multiple submitters
tooth agenesis, selective, 4
WNT10A p.Arg223Ser Uncertain significance Multiple submitters
Inborn genetic diseases
WNT10A p.Arg260Gln Uncertain significance Multiple submitters
Inborn genetic diseases
WNT10A p.Arg305His Uncertain significance Multiple submitters
odonto-onycho-dermal dysplasia
WNT10A p.Arg388Cys Uncertain significance Multiple submitters
Inborn genetic diseases
WNT10A p.Cys394Tyr Uncertain significance Multiple submitters
odonto-onycho-dermal dysplasia
WNT10A p.Cys404Trp Uncertain significance Multiple submitters
tooth agenesis, selective, 4
WNT10A p.Cys96Arg Uncertain significance Multiple submitters
WNT10A p.Gln71Leu Uncertain significance Multiple submitters
tooth agenesis, selective, 4
WNT10A p.Gly316Arg Uncertain significance Multiple submitters
Inborn genetic diseases
WNT10A p.Leu67Pro Uncertain significance Multiple submitters
Inborn genetic diseases
WNT10A p.Lys263Asn Uncertain significance Multiple submitters
tooth agenesis, selective, 4
WNT10A p.Pro20Gln Uncertain significance Multiple submitters
odonto-onycho-dermal dysplasia
WNT10A p.Pro350Leu Uncertain significance Multiple submitters
tooth agenesis, selective, 4
WNT10A p.Pro51Leu Uncertain significance Multiple submitters
odonto-onycho-dermal dysplasia
WNT10A p.Ser146Cys Uncertain significance Multiple submitters
Inborn genetic diseases
WNT10A p.Val81Ala Uncertain significance Multiple submitters
Inborn genetic diseases
WNT10A p.Ala137Pro Uncertain significance Single submitter
WNT10A p.Ala144Pro Uncertain significance Single submitter
WNT10A p.Ala161Val Uncertain significance Single submitter
Inborn genetic diseases
WNT10A p.Ala181Val Uncertain significance Single submitter
odonto-onycho-dermal dysplasia
WNT10A p.Ala253Val Uncertain significance Single submitter
Inborn genetic diseases
WNT10A p.Ala317Pro Uncertain significance Single submitter
Inborn genetic diseases
WNT10A p.Ala331Asp Uncertain significance Single submitter
Inborn genetic diseases
WNT10A p.Arg104Pro Uncertain significance Single submitter
WNT10A p.Arg11Trp Uncertain significance Single submitter
Inborn genetic diseases
WNT10A p.Arg125Ser Uncertain significance Single submitter
WNT10A p.Arg163Gln Uncertain significance Single submitter
odonto-onycho-dermal dysplasia
WNT10A p.Arg232Gln Uncertain significance Single submitter
tooth agenesis, selective, 4
WNT10A p.Arg284Leu Uncertain significance Single submitter
WNT10A p.Arg293Cys Uncertain significance Single submitter
Abnormality of the dentition
WNT10A p.Arg330Gln Uncertain significance Single submitter
WNT10A p.Arg330Pro Uncertain significance Single submitter
Inborn genetic diseases
WNT10A p.Arg348Cys Uncertain significance Single submitter
Abnormality of the dentition
WNT10A p.Arg351Leu Uncertain significance Single submitter
Inborn genetic diseases
WNT10A p.Arg385His Uncertain significance Single submitter
odonto-onycho-dermal dysplasia
WNT10A p.Arg38Trp Uncertain significance Single submitter
WNT10A-related disorder
WNT10A p.Arg395Cys Uncertain significance Single submitter
tooth agenesis, selective, 4
WNT10A p.Arg408His Uncertain significance Single submitter
odonto-onycho-dermal dysplasia
WNT10A p.Arg48Cys Uncertain significance Single submitter
tooth agenesis, selective, 4
WNT10A p.Arg69Gln Uncertain significance Single submitter
WNT10A p.Arg70Gln Uncertain significance Single submitter
Inborn genetic diseases
WNT10A p.Arg7Ser Uncertain significance Single submitter
Inborn genetic diseases
WNT10A p.Asn306His Uncertain significance Single submitter
Inborn genetic diseases
WNT10A p.Asn56Asp Uncertain significance Single submitter
tooth agenesis, selective, 4
WNT10A p.Cys107Ser Uncertain significance Single submitter
odonto-onycho-dermal dysplasia
WNT10A p.Cys107Tyr Uncertain significance Single submitter
Inborn genetic diseases
WNT10A p.Cys214Arg Uncertain significance Single submitter
odonto-onycho-dermal dysplasia
WNT10A p.Cys264Phe Uncertain significance Single submitter
tooth agenesis, selective, 4
WNT10A p.Cys276Phe Uncertain significance Single submitter
WNT10A p.Cys346Arg Uncertain significance Single submitter
odonto-onycho-dermal dysplasia
WNT10A p.Cys362Phe Uncertain significance Single submitter
odonto-onycho-dermal dysplasia
WNT10A p.Cys376Ser Uncertain significance Single submitter
tooth agenesis, selective, 4
WNT10A p.Cys404Phe Uncertain significance Single submitter
Inborn genetic diseases
WNT10A p.Glu167Gln Uncertain significance Single submitter
WNT10A p.Glu73Lys Uncertain significance Single submitter
Inborn genetic diseases
WNT10A p.Gly185Asp Uncertain significance Single submitter
odonto-onycho-dermal dysplasia
WNT10A p.Gly191Glu Uncertain significance Single submitter
WNT10A p.Gly307Arg Uncertain significance Single submitter
odonto-onycho-dermal dysplasia
WNT10A p.Gly308Val Uncertain significance Single submitter
Inborn genetic diseases
WNT10A p.Gly313Arg Uncertain significance Single submitter
WNT10A p.Gly316Ala Uncertain significance Single submitter
Inborn genetic diseases
WNT10A p.Gly323Ser Uncertain significance Single submitter
Inborn genetic diseases
WNT10A p.Gly380Ser Uncertain significance Single submitter
odonto-onycho-dermal dysplasia
WNT10A p.Gly88Cys Uncertain significance Single submitter
tooth agenesis, selective, 4
WNT10A p.Gly88Ser Uncertain significance Single submitter
tooth agenesis, selective, 4
WNT10A p.His175Tyr Uncertain significance Single submitter
Inborn genetic diseases
WNT10A p.His195Gln Uncertain significance Single submitter
Inborn genetic diseases
WNT10A p.His98Gln Uncertain significance Single submitter
Inborn genetic diseases
WNT10A p.His98Pro Uncertain significance Single submitter
Schöpf-Schulz-Passarge syndrome
WNT10A p.Ile238Leu Uncertain significance Single submitter
Inborn genetic diseases
WNT10A p.Leu310Arg Uncertain significance Single submitter
Inborn genetic diseases
WNT10A p.Lys173Asn Uncertain significance Single submitter
odonto-onycho-dermal dysplasia
WNT10A p.Lys186Thr Uncertain significance Single submitter
WNT10A p.Met375Arg Uncertain significance Single submitter
tooth agenesis, selective, 4
WNT10A p.Met375Thr Uncertain significance Single submitter
tooth agenesis, selective, 4
WNT10A p.Phe224Ser Uncertain significance Single submitter
WNT10A p.Phe228Leu Uncertain significance Single submitter
WNT10A p.Phe27Ile Uncertain significance Single submitter
Inborn genetic diseases
WNT10A p.Phe294Val Uncertain significance Single submitter
Inborn genetic diseases
WNT10A p.Phe345Leu Uncertain significance Single submitter
tooth agenesis, selective, 4
WNT10A p.Pro18Leu Uncertain significance Single submitter
Inborn genetic diseases
WNT10A p.Pro318His Uncertain significance Single submitter
Inborn genetic diseases
WNT10A p.Pro320Arg Uncertain significance Single submitter
odonto-onycho-dermal dysplasia
WNT10A p.Pro320Ser Uncertain significance Single submitter
Inborn genetic diseases
WNT10A p.Pro327Gln Uncertain significance Single submitter
WNT10A p.Pro51Arg Uncertain significance Single submitter
WNT10A p.Ser108Leu Uncertain significance Single submitter
odonto-onycho-dermal dysplasia
WNT10A p.Ser124Gly Uncertain significance Single submitter
Inborn genetic diseases
WNT10A p.Ser208Phe Uncertain significance Single submitter
tooth agenesis, selective, 4
WNT10A p.Ser215Arg Uncertain significance Single submitter
WNT10A p.Ser268Pro Uncertain significance Single submitter
Inborn genetic diseases
WNT10A p.Ser354Leu Uncertain significance Single submitter
tooth agenesis, selective, 4
WNT10A p.Ser366Arg Uncertain significance Single submitter
Inborn genetic diseases
WNT10A p.Ser3Cys Uncertain significance Single submitter
tooth agenesis, selective, 4
WNT10A p.Thr200Arg Uncertain significance Single submitter
Inborn genetic diseases
WNT10A p.Thr275Ala Uncertain significance Single submitter
WNT10A p.Thr280Met Uncertain significance Single submitter
tooth agenesis, selective, 4
WNT10A p.Thr280Ser Uncertain significance Single submitter
tooth agenesis, selective, 4
WNT10A p.Trp105Cys Uncertain significance Single submitter
tooth agenesis, selective, 4
WNT10A p.Val145Ala Uncertain significance Single submitter
tooth agenesis, selective, 4
WNT10A p.Val402Met Uncertain significance Single submitter
tooth agenesis, selective, 4
WNT10A p.Ala4Thr Uncertain significance No assertion criteria
Schöpf-Schulz-Passarge syndrome
WNT10A p.Ala4Val Uncertain significance No assertion criteria
Schöpf-Schulz-Passarge syndrome
WNT10A p.Arg104Ser Uncertain significance No assertion criteria
tooth agenesis, selective, 4
WNT10A p.Arg328Cys Uncertain significance No assertion criteria
Schöpf-Schulz-Passarge syndrome
WNT10A p.Arg348Ser Uncertain significance No assertion criteria
Schöpf-Schulz-Passarge syndrome
WNT10A p.Cys376Phe Uncertain significance No assertion criteria
tooth agenesis, selective, 4
WNT10A p.Gly308Ser Uncertain significance No assertion criteria
Schöpf-Schulz-Passarge syndrome
WNT10A p.Gly356Ala Uncertain significance No assertion criteria
Schöpf-Schulz-Passarge syndrome
WNT10A p.His98Tyr Uncertain significance No assertion criteria
Schöpf-Schulz-Passarge syndrome
WNT10A p.Leu10Arg Uncertain significance No assertion criteria
Schöpf-Schulz-Passarge syndrome
WNT10A p.Leu154Met Uncertain significance No assertion criteria
WNT10A-related disorder
WNT10A p.Leu299Arg Uncertain significance No assertion criteria
Schöpf-Schulz-Passarge syndrome
WNT10A p.Pro314Gln Uncertain significance No assertion criteria
Schöpf-Schulz-Passarge syndrome
WNT10A p.Pro325Leu Uncertain significance No assertion criteria
Schöpf-Schulz-Passarge syndrome
WNT10A p.Pro37Ser Uncertain significance No assertion criteria
Schöpf-Schulz-Passarge syndrome
WNT10A p.Pro41Leu Uncertain significance No assertion criteria
Schöpf-Schulz-Passarge syndrome
WNT10A p.Ser130Arg Uncertain significance No assertion criteria
WNT10A-related disorder
WNT10A p.Val279Gly Uncertain significance No assertion criteria
Schöpf-Schulz-Passarge syndrome

Predictors split 38

The independent predictors disagree with each other — read with care.

WNT10A p.Asn306Lys Likely benign Multiple submitters
odonto-onycho-dermal dysplasia
WNT10A p.Glu347Ala Uncertain significance Multiple submitters
odonto-onycho-dermal dysplasia
WNT10A p.Gly126Ser Likely pathogenic Multiple submitters
odonto-onycho-dermal dysplasia
WNT10A p.Pro281Thr Uncertain significance Multiple submitters
Inborn genetic diseases
WNT10A p.Ala137Thr Uncertain significance Single submitter
WNT10A p.Ala240Val Conflicting Single submitter
odonto-onycho-dermal dysplasia
WNT10A p.Arg163Trp Conflicting Single submitter
WNT10A-related disorder
WNT10A p.Arg172Trp Conflicting Single submitter
tooth agenesis, selective, 4
WNT10A p.Arg232Trp Uncertain significance Single submitter
tooth agenesis, selective, 4
WNT10A p.Arg243Ser Uncertain significance Single submitter
Inborn genetic diseases
WNT10A p.Arg259Trp Uncertain significance Single submitter
odonto-onycho-dermal dysplasia
WNT10A p.Arg70Trp Conflicting Single submitter
odonto-onycho-dermal dysplasia
WNT10A p.Arg77His Uncertain significance Single submitter
Inborn genetic diseases
WNT10A p.Asn304His Conflicting Single submitter
odonto-onycho-dermal dysplasia
WNT10A p.Asp335Ala Uncertain significance Single submitter
Inborn genetic diseases
WNT10A p.Asp370Ala Uncertain significance Single submitter
Inborn genetic diseases
WNT10A p.Glu233Lys Conflicting Single submitter
tooth agenesis, selective, 4
WNT10A p.Glu390Lys Uncertain significance Single submitter
WNT10A p.His239Tyr Uncertain significance Single submitter
Inborn genetic diseases
WNT10A p.Ile116Thr Conflicting Single submitter
odonto-onycho-dermal dysplasia
WNT10A p.Ile300Phe Uncertain significance Single submitter
odonto-onycho-dermal dysplasia
WNT10A p.Ile44Thr Uncertain significance Single submitter
WNT10A p.Leu384Gln Uncertain significance Single submitter
WNT10A p.Met218Arg Uncertain significance Single submitter
tooth agenesis, selective, 4
WNT10A p.Met72Ile Uncertain significance Single submitter
Inborn genetic diseases
WNT10A p.Phe224Leu Uncertain significance Single submitter
odonto-onycho-dermal dysplasia
WNT10A p.Phe339Leu Uncertain significance Single submitter
Inborn genetic diseases
WNT10A p.Pro117Ser Uncertain significance Single submitter
tooth agenesis, selective, 4
WNT10A p.Pro281Ala Conflicting Single submitter
Inborn genetic diseases
WNT10A p.Ser231Phe Uncertain significance Single submitter
Inborn genetic diseases
WNT10A p.Tyr118Cys Likely pathogenic Single submitter
tooth agenesis, selective, 4
WNT10A p.Val249Ile Likely benign Single submitter
odonto-onycho-dermal dysplasia
WNT10A p.Val54Met Uncertain significance Single submitter
Inborn genetic diseases
WNT10A p.Arg260Trp Uncertain significance No assertion criteria
Schöpf-Schulz-Passarge syndrome
WNT10A p.Gln386His Uncertain significance No assertion criteria
Schöpf-Schulz-Passarge syndrome
WNT10A p.Leu55Phe Uncertain significance No assertion criteria
Schöpf-Schulz-Passarge syndrome
WNT10A p.Pro117Arg Uncertain significance No assertion criteria
Schöpf-Schulz-Passarge syndrome
WNT10A p.Pro65Leu Uncertain significance No assertion criteria
Schöpf-Schulz-Passarge syndrome

All WNT10A variants

Pathogenic 56

c.376+1G>A Multiple submitters odonto-onycho-dermal dysplasia
p.Arg248Ter Multiple submitters Inborn genetic diseases
p.Gln178fs Multiple submitters odonto-onycho-dermal dysplasia
p.Glu222Ter Multiple submitters odonto-onycho-dermal dysplasia
p.Ser268Ter Multiple submitters WNT10A-related disorder
p.Ala21fs Single submitter odonto-onycho-dermal dysplasia
p.Ala355fs Single submitter odonto-onycho-dermal dysplasia
p.Ala85fs Single submitter odonto-onycho-dermal dysplasia
p.Arg128Ter Single submitter odonto-onycho-dermal dysplasia
p.Arg164Ter Single submitter odonto-onycho-dermal dysplasia
p.Arg232fs Single submitter odonto-onycho-dermal dysplasia
p.Arg328fs Single submitter odonto-onycho-dermal dysplasia
p.Arg329fs Single submitter
p.Arg330fs Single submitter odonto-onycho-dermal dysplasia
p.Asp217fs Single submitter odonto-onycho-dermal dysplasia
p.Cys271Ter Single submitter odonto-onycho-dermal dysplasia
p.Cys346fs Single submitter tooth agenesis, selective, 4
p.Cys376Ter Single submitter odonto-onycho-dermal dysplasia
p.Gln178Ter Single submitter odonto-onycho-dermal dysplasia
p.Gln183Ter Single submitter tooth agenesis, selective, 4
p.Gln87Ter Single submitter tooth agenesis, selective, 4
p.Gln99fs Single submitter odonto-onycho-dermal dysplasia
p.Glu129fs Single submitter odonto-onycho-dermal dysplasia
p.Glu168fs Single submitter tooth agenesis, selective, 4
p.Glu194fs Single submitter tooth agenesis, selective, 4
p.Glu233Ter Single submitter odonto-onycho-dermal dysplasia
p.Glu311fs Single submitter tooth agenesis, selective, 4
p.Glu340Ter Single submitter odonto-onycho-dermal dysplasia
p.Glu349fs Single submitter tooth agenesis, selective, 4
p.Gly2fs Single submitter odonto-onycho-dermal dysplasia
p.His239fs Single submitter odonto-onycho-dermal dysplasia
p.His303fs Single submitter odonto-onycho-dermal dysplasia
p.His381fs Single submitter odonto-onycho-dermal dysplasia
p.Leu29fs Single submitter odonto-onycho-dermal dysplasia
p.Met1Val Single submitter tooth agenesis, selective, 4
p.Met36fs Single submitter odonto-onycho-dermal dysplasia
p.Phe127fs Single submitter odonto-onycho-dermal dysplasia
p.Phe283fs Single submitter odonto-onycho-dermal dysplasia
p.Pro20fs Single submitter odonto-onycho-dermal dysplasia
p.Pro302fs Single submitter odonto-onycho-dermal dysplasia
p.Pro51fs Single submitter odonto-onycho-dermal dysplasia
p.Ser225fs Single submitter odonto-onycho-dermal dysplasia
p.Ser319Ter Single submitter tooth agenesis, selective, 4
p.Ser332fs Single submitter odonto-onycho-dermal dysplasia
p.Ser365fs Single submitter odonto-onycho-dermal dysplasia
p.Ser389fs Single submitter tooth agenesis, selective, 4
p.Ser3fs Single submitter odonto-onycho-dermal dysplasia
p.Thr267fs Single submitter tooth agenesis, selective, 4
p.Thr357Ile Single submitter tooth agenesis, selective, 4
p.Trp105Ter Single submitter odonto-onycho-dermal dysplasia
p.Trp277Ter Single submitter odonto-onycho-dermal dysplasia
p.Tyr118Ter Single submitter odonto-onycho-dermal dysplasia
p.Val192fs Single submitter tooth agenesis, selective, 4
c.756+1G>A No assertion criteria odonto-onycho-dermal dysplasia
p.Ile300fs No assertion criteria odonto-onycho-dermal dysplasia
p.Trp9Ter No assertion criteria tooth agenesis, selective, 4

Pathogenic/Likely pathogenic 24

p.Ala131Thr Multiple submitters Schöpf-Schulz-Passarge syndrome
p.Ala317fs Multiple submitters odonto-onycho-dermal dysplasia
p.Arg104Cys Multiple submitters odonto-onycho-dermal dysplasia
p.Arg128Gln Multiple submitters tooth agenesis, selective, 4 ⚠
p.Arg13Ter Multiple submitters tooth agenesis, selective, 4
p.Asp335fs Multiple submitters tooth agenesis, selective, 4
p.Cys107Ter Multiple submitters WNT10A-related disorder
p.Cys271fs Multiple submitters odonto-onycho-dermal dysplasia
p.Cys362Arg Multiple submitters odonto-onycho-dermal dysplasia
p.Cys400Tyr Multiple submitters odonto-onycho-dermal dysplasia
p.Gln272Ter Multiple submitters odonto-onycho-dermal dysplasia
p.Gln278Ter Multiple submitters odonto-onycho-dermal dysplasia
p.Gln97Ter Multiple submitters odonto-onycho-dermal dysplasia
p.Glu282Ter Multiple submitters odonto-onycho-dermal dysplasia
p.Glu390Ter Multiple submitters odonto-onycho-dermal dysplasia
p.Glu95Lys Multiple submitters tooth agenesis, selective, 4
p.Ile409fs Multiple submitters odonto-onycho-dermal dysplasia
p.Met1Ile Multiple submitters tooth agenesis, selective, 4
p.Met1Leu Multiple submitters tooth agenesis, selective, 4
p.Pro312fs Multiple submitters odonto-onycho-dermal dysplasia
p.Ser108Pro Multiple submitters odonto-onycho-dermal dysplasia
p.Trp209Ter Multiple submitters odonto-onycho-dermal dysplasia
p.Trp23Ter Multiple submitters tooth agenesis, selective, 4
p.Val145Met Multiple submitters odonto-onycho-dermal dysplasia

Likely pathogenic 26

c.113+1G>A Multiple submitters tooth agenesis, selective, 4
c.113+1G>T Multiple submitters odonto-onycho-dermal dysplasia
p.Ala297Thr Multiple submitters odonto-onycho-dermal dysplasia
p.Cys416Tyr Multiple submitters Schöpf-Schulz-Passarge syndrome
p.Gly126Ser Multiple submitters odonto-onycho-dermal dysplasia ⚠
c.114-1G>A Single submitter Schöpf-Schulz-Passarge syndrome
p.Ala92Thr Single submitter odonto-onycho-dermal dysplasia
p.Arg360Pro Single submitter tooth agenesis, selective, 4
p.Arg379Cys Single submitter odonto-onycho-dermal dysplasia
p.Asp166fs Single submitter Schöpf-Schulz-Passarge syndrome
p.Cys271Tyr Single submitter tooth agenesis, selective, 4
p.Cys276Ser Single submitter Schöpf-Schulz-Passarge syndrome
p.Cys392Ter Single submitter Schöpf-Schulz-Passarge syndrome
p.Gln252Ter Single submitter Schöpf-Schulz-Passarge syndrome
p.Glu222fs Single submitter Schöpf-Schulz-Passarge syndrome
p.Glu52fs Single submitter Schöpf-Schulz-Passarge syndrome
p.Gly221Val Single submitter odonto-onycho-dermal dysplasia
p.Met1_His5del Single submitter odonto-onycho-dermal dysplasia
p.Met1Arg Single submitter Schöpf-Schulz-Passarge syndrome
p.Met242Arg Single submitter Inborn genetic diseases
p.Pro343Leu Single submitter odonto-onycho-dermal dysplasia
p.Trp211Ter Single submitter Schöpf-Schulz-Passarge syndrome
p.Tyr118Cys Single submitter tooth agenesis, selective, 4 ⚠
p.Gln206Ter No assertion criteria odonto-onycho-dermal dysplasia
p.Gly356Ser No assertion criteria odonto-onycho-dermal dysplasia
p.Leu174Pro No assertion criteria tooth agenesis, selective, 4

Conflicting classifications of pathogenicity 39

c.377-11T>C Single submitter tooth agenesis, selective, 4
c.756+13C>A Single submitter tooth agenesis, selective, 4
c.756+14C>T Single submitter tooth agenesis, selective, 4
p.Ala135Thr Single submitter odonto-onycho-dermal dysplasia ⚠
p.Ala21Gly Single submitter tooth agenesis, selective, 4 ⚠
p.Ala240Val Single submitter odonto-onycho-dermal dysplasia ⚠
p.Arg104His Single submitter tooth agenesis, selective, 4 ⚠
p.Arg113Cys Single submitter odonto-onycho-dermal dysplasia ⚠
p.Arg163Trp Single submitter WNT10A-related disorder ⚠
p.Arg171Cys Single submitter odonto-onycho-dermal dysplasia ⚠
p.Arg171His Single submitter odonto-onycho-dermal dysplasia ⚠
p.Arg172Trp Single submitter tooth agenesis, selective, 4 ⚠
p.Arg184His Single submitter Schöpf-Schulz-Passarge syndrome ⚠
p.Arg360Leu Single submitter tooth agenesis, selective, 4 ⚠
p.Arg70Trp Single submitter odonto-onycho-dermal dysplasia ⚠
p.Asn106Lys Single submitter odonto-onycho-dermal dysplasia ⚠
p.Asn304His Single submitter odonto-onycho-dermal dysplasia ⚠
p.Asn363His Single submitter odonto-onycho-dermal dysplasia ⚠
p.Asp166= Single submitter tooth agenesis, selective, 4
p.Asp217Asn Single submitter odonto-onycho-dermal dysplasia ⚠
p.Asp217Gly Single submitter odonto-onycho-dermal dysplasia ⚠
p.Cys372Gly Single submitter odonto-onycho-dermal dysplasia ⚠
p.Cys400Ser Single submitter odonto-onycho-dermal dysplasia ⚠
p.Glu233Lys Single submitter tooth agenesis, selective, 4 ⚠
p.Gly152= Single submitter odonto-onycho-dermal dysplasia
p.Gly165Arg Single submitter odonto-onycho-dermal dysplasia ⚠
p.Gly213Ser Single submitter odonto-onycho-dermal dysplasia ⚠
p.Gly221Arg Single submitter odonto-onycho-dermal dysplasia ⚠
p.Gly266Ser Single submitter odonto-onycho-dermal dysplasia ⚠
p.Gly378= Single submitter tooth agenesis, selective, 4
p.Ile116Thr Single submitter odonto-onycho-dermal dysplasia ⚠
p.Ile136Met Single submitter odonto-onycho-dermal dysplasia ⚠
p.Met218Val Single submitter tooth agenesis, selective, 4 ⚠
p.Phe339= Single submitter tooth agenesis, selective, 4
p.Phe345Ser Single submitter tooth agenesis, selective, 4 ⚠
p.Pro281Ala Single submitter Inborn genetic diseases ⚠
p.Pro50Leu Single submitter ectodermal dysplasia WNT10A related ⚠
p.Ser270Arg Single submitter tooth agenesis, selective, 4 ⚠
p.Trp277Cys Single submitter odonto-onycho-dermal dysplasia ⚠

Benign 2

c.114-56T>C Multiple submitters
p.Leu273Ile Multiple submitters odonto-onycho-dermal dysplasia

Benign/Likely benign 5

c.*431C>T Multiple submitters tooth agenesis, selective, 4
p.Ala197= Multiple submitters tooth agenesis, selective, 4
p.Asp335Asn Multiple submitters Schöpf-Schulz-Passarge syndrome
p.Gln178= Multiple submitters odonto-onycho-dermal dysplasia
p.His78= Multiple submitters odonto-onycho-dermal dysplasia

Likely benign 230

c.756+7G>A Multiple submitters odonto-onycho-dermal dysplasia
p.Ala161= Multiple submitters odonto-onycho-dermal dysplasia
p.Asn306Lys Multiple submitters odonto-onycho-dermal dysplasia ⚠
p.Asp335= Multiple submitters odonto-onycho-dermal dysplasia
p.Gly2Ser Multiple submitters odonto-onycho-dermal dysplasia
p.Tyr134= Multiple submitters tooth agenesis, selective, 4
c.113+10C>T Single submitter tooth agenesis, selective, 4
c.113+17T>C Single submitter odonto-onycho-dermal dysplasia
c.113+19C>T Single submitter odonto-onycho-dermal dysplasia
c.113+7C>A Single submitter odonto-onycho-dermal dysplasia
c.113+8C>A Single submitter odonto-onycho-dermal dysplasia
c.114-10A>G Single submitter tooth agenesis, selective, 4
c.114-10A>T Single submitter tooth agenesis, selective, 4
c.114-16C>T Single submitter odonto-onycho-dermal dysplasia
c.114-8G>A Single submitter odonto-onycho-dermal dysplasia
c.376+13_376+14insCTTTCTTTCCAAGTTATGGATGTCCATTGTGTGGGGTCAGGTGACCTCCGTTTCCTCCA Single submitter odonto-onycho-dermal dysplasia
c.376+17C>A Single submitter odonto-onycho-dermal dysplasia
c.376+17C>G Single submitter odonto-onycho-dermal dysplasia
c.376+18C>A Single submitter tooth agenesis, selective, 4
c.376+19T>C Single submitter tooth agenesis, selective, 4
c.376+8C>T Single submitter odonto-onycho-dermal dysplasia
c.376+9C>T Single submitter tooth agenesis, selective, 4
c.377-12_377-10del Single submitter odonto-onycho-dermal dysplasia
c.377-18C>G Single submitter odonto-onycho-dermal dysplasia
c.756+14C>A Single submitter odonto-onycho-dermal dysplasia
c.756+15C>A Single submitter odonto-onycho-dermal dysplasia
c.756+17del Single submitter odonto-onycho-dermal dysplasia
c.756+17T>C Single submitter odonto-onycho-dermal dysplasia
c.756+18G>A Single submitter odonto-onycho-dermal dysplasia
c.756+20G>A Single submitter odonto-onycho-dermal dysplasia
c.756+9C>A Single submitter tooth agenesis, selective, 4
c.757-16G>A Single submitter tooth agenesis, selective, 4
c.757-17G>T Single submitter odonto-onycho-dermal dysplasia
c.757-20C>A Single submitter tooth agenesis, selective, 4
c.757-6C>T Single submitter odonto-onycho-dermal dysplasia
c.757-9C>A Single submitter tooth agenesis, selective, 4
c.*128T>C Single submitter tooth agenesis, selective, 4
c.*216G>C Single submitter tooth agenesis, selective, 4
c.*275C>T Single submitter tooth agenesis, selective, 4
p.Ala133= Single submitter tooth agenesis, selective, 4
p.Ala135= Single submitter odonto-onycho-dermal dysplasia
p.Ala144= Single submitter odonto-onycho-dermal dysplasia
p.Ala148= Single submitter tooth agenesis, selective, 4
p.Ala150= Single submitter odonto-onycho-dermal dysplasia
p.Ala156= Single submitter tooth agenesis, selective, 4
p.Ala169= Single submitter odonto-onycho-dermal dysplasia
p.Ala21= Single submitter odonto-onycho-dermal dysplasia
p.Ala240= Single submitter odonto-onycho-dermal dysplasia
p.Ala288= Single submitter odonto-onycho-dermal dysplasia
p.Ala297= Single submitter tooth agenesis, selective, 4
p.Ala315= Single submitter tooth agenesis, selective, 4
p.Ala317= Single submitter odonto-onycho-dermal dysplasia
p.Ala334= Single submitter tooth agenesis, selective, 4
p.Ala35= Single submitter tooth agenesis, selective, 4
p.Ala367= Single submitter tooth agenesis, selective, 4
p.Ala92= Single submitter odonto-onycho-dermal dysplasia
p.Arg11= Single submitter odonto-onycho-dermal dysplasia
p.Arg13= Single submitter odonto-onycho-dermal dysplasia
p.Arg163= Single submitter odonto-onycho-dermal dysplasia
p.Arg248= Single submitter odonto-onycho-dermal dysplasia
p.Arg259= Single submitter odonto-onycho-dermal dysplasia
p.Arg301= Single submitter odonto-onycho-dermal dysplasia
p.Arg301Pro Single submitter tooth agenesis, selective, 4
p.Arg305= Single submitter odonto-onycho-dermal dysplasia
p.Arg348= Single submitter odonto-onycho-dermal dysplasia
p.Arg351= Single submitter odonto-onycho-dermal dysplasia
p.Arg360= Single submitter tooth agenesis, selective, 4
p.Arg379= Single submitter tooth agenesis, selective, 4
p.Arg385= Single submitter odonto-onycho-dermal dysplasia
p.Arg388= Single submitter odonto-onycho-dermal dysplasia
p.Arg391= Single submitter odonto-onycho-dermal dysplasia
p.Arg395= Single submitter odonto-onycho-dermal dysplasia
p.Arg7= Single submitter odonto-onycho-dermal dysplasia
p.Arg70= Single submitter odonto-onycho-dermal dysplasia
p.Asn106= Single submitter odonto-onycho-dermal dysplasia
p.Asn114= Single submitter odonto-onycho-dermal dysplasia
p.Asn147= Single submitter odonto-onycho-dermal dysplasia
p.Asn246= Single submitter tooth agenesis, selective, 4
p.Asn247= Single submitter odonto-onycho-dermal dysplasia
p.Asn257= Single submitter odonto-onycho-dermal dysplasia
p.Asn306= Single submitter odonto-onycho-dermal dysplasia
p.Asn382= Single submitter odonto-onycho-dermal dysplasia
p.Asn42Ser Single submitter odonto-onycho-dermal dysplasia
p.Asn56= Single submitter tooth agenesis, selective, 4
p.Asn58= Single submitter odonto-onycho-dermal dysplasia
p.Asp102= Single submitter odonto-onycho-dermal dysplasia
p.Asp180= Single submitter odonto-onycho-dermal dysplasia
p.Asp227= Single submitter odonto-onycho-dermal dysplasia
p.Asp230= Single submitter tooth agenesis, selective, 4
p.Asp353= Single submitter tooth agenesis, selective, 4
p.Asp370= Single submitter tooth agenesis, selective, 4
p.Asp46= Single submitter odonto-onycho-dermal dysplasia
p.Cys159= Single submitter odonto-onycho-dermal dysplasia
p.Cys214= Single submitter odonto-onycho-dermal dysplasia
p.Cys271= Single submitter odonto-onycho-dermal dysplasia
p.Cys372= Single submitter tooth agenesis, selective, 4
p.Cys376= Single submitter odonto-onycho-dermal dysplasia
p.Cys377= Single submitter odonto-onycho-dermal dysplasia
p.Cys399= Single submitter odonto-onycho-dermal dysplasia
p.Cys404= Single submitter odonto-onycho-dermal dysplasia
p.Cys407= Single submitter odonto-onycho-dermal dysplasia
p.Cys96= Single submitter odonto-onycho-dermal dysplasia
p.Gln103= Single submitter odonto-onycho-dermal dysplasia
p.Gln15= Single submitter odonto-onycho-dermal dysplasia
p.Gln272= Single submitter odonto-onycho-dermal dysplasia
p.Gln309= Single submitter odonto-onycho-dermal dysplasia
p.Gln386= Single submitter tooth agenesis, selective, 4
p.Gln99= Single submitter odonto-onycho-dermal dysplasia
p.Glu129= Single submitter odonto-onycho-dermal dysplasia
p.Glu222= Single submitter odonto-onycho-dermal dysplasia
p.Glu347= Single submitter odonto-onycho-dermal dysplasia
p.Glu349= Single submitter tooth agenesis, selective, 4
p.Glu390= Single submitter odonto-onycho-dermal dysplasia
p.Glu406= Single submitter tooth agenesis, selective, 4
p.Glu52= Single submitter odonto-onycho-dermal dysplasia
p.Glu73= Single submitter tooth agenesis, selective, 4
p.Gly140= Single submitter odonto-onycho-dermal dysplasia
p.Gly158= Single submitter odonto-onycho-dermal dysplasia
p.Gly165= Single submitter odonto-onycho-dermal dysplasia
p.Gly185= Single submitter odonto-onycho-dermal dysplasia
p.Gly187= Single submitter odonto-onycho-dermal dysplasia
p.Gly191= Single submitter odonto-onycho-dermal dysplasia
p.Gly204= Single submitter odonto-onycho-dermal dysplasia
p.Gly212= Single submitter odonto-onycho-dermal dysplasia
p.Gly221= Single submitter odonto-onycho-dermal dysplasia
p.Gly313= Single submitter tooth agenesis, selective, 4
p.Gly323= Single submitter odonto-onycho-dermal dysplasia
p.Gly380= Single submitter odonto-onycho-dermal dysplasia
p.His143= Single submitter odonto-onycho-dermal dysplasia
p.His175= Single submitter odonto-onycho-dermal dysplasia
p.His190= Single submitter odonto-onycho-dermal dysplasia
p.His195= Single submitter odonto-onycho-dermal dysplasia
p.His235= Single submitter odonto-onycho-dermal dysplasia
p.His239= Single submitter odonto-onycho-dermal dysplasia
p.His265= Single submitter odonto-onycho-dermal dysplasia
p.His381= Single submitter odonto-onycho-dermal dysplasia
p.His393= Single submitter odonto-onycho-dermal dysplasia
p.His94= Single submitter odonto-onycho-dermal dysplasia
p.Ile116= Single submitter odonto-onycho-dermal dysplasia
p.Ile136= Single submitter odonto-onycho-dermal dysplasia
p.Ile300= Single submitter odonto-onycho-dermal dysplasia
p.Ile383= Single submitter odonto-onycho-dermal dysplasia
p.Ile44= Single submitter odonto-onycho-dermal dysplasia
p.Ile89= Single submitter odonto-onycho-dermal dysplasia
p.Ile91= Single submitter odonto-onycho-dermal dysplasia
p.Ile93= Single submitter odonto-onycho-dermal dysplasia
p.Leu12= Single submitter tooth agenesis, selective, 4
p.Leu154= Single submitter odonto-onycho-dermal dysplasia
p.Leu174= Single submitter
p.Leu177= Single submitter tooth agenesis, selective, 4
p.Leu179= Single submitter odonto-onycho-dermal dysplasia
p.Leu182= Single submitter odonto-onycho-dermal dysplasia
p.Leu188= Single submitter odonto-onycho-dermal dysplasia
p.Leu198= Single submitter odonto-onycho-dermal dysplasia
p.Leu205= Single submitter tooth agenesis, selective, 4
p.Leu244= Single submitter odonto-onycho-dermal dysplasia
p.Leu25= Single submitter odonto-onycho-dermal dysplasia
p.Leu26= Single submitter odonto-onycho-dermal dysplasia
p.Leu273= Single submitter tooth agenesis, selective, 4
p.Leu29= Single submitter odonto-onycho-dermal dysplasia
p.Leu30= Single submitter odonto-onycho-dermal dysplasia
p.Leu310= Single submitter tooth agenesis, selective, 4
p.Leu32= Single submitter odonto-onycho-dermal dysplasia
p.Leu336= Single submitter odonto-onycho-dermal dysplasia
p.Leu352= Single submitter odonto-onycho-dermal dysplasia
p.Leu361= Single submitter odonto-onycho-dermal dysplasia
p.Leu45= Single submitter odonto-onycho-dermal dysplasia
p.Leu49= Single submitter odonto-onycho-dermal dysplasia
p.Leu62= Single submitter odonto-onycho-dermal dysplasia
p.Leu64= Single submitter odonto-onycho-dermal dysplasia
p.Leu67= Single submitter odonto-onycho-dermal dysplasia
p.Lys155= Single submitter odonto-onycho-dermal dysplasia
p.Lys186= Single submitter odonto-onycho-dermal dysplasia
p.Lys274= Single submitter odonto-onycho-dermal dysplasia
p.Lys341= Single submitter odonto-onycho-dermal dysplasia
p.Lys364= Single submitter tooth agenesis, selective, 4
p.Lys417= Single submitter odonto-onycho-dermal dysplasia
p.Phe220= Single submitter odonto-onycho-dermal dysplasia
p.Phe27= Single submitter odonto-onycho-dermal dysplasia
p.Phe294= Single submitter odonto-onycho-dermal dysplasia
p.Phe396= Single submitter tooth agenesis, selective, 4
p.Pro117= Single submitter tooth agenesis, selective, 4
p.Pro121= Single submitter odonto-onycho-dermal dysplasia
p.Pro14= Single submitter tooth agenesis, selective, 4
p.Pro18= Single submitter odonto-onycho-dermal dysplasia
p.Pro193= Single submitter odonto-onycho-dermal dysplasia
p.Pro203= Single submitter odonto-onycho-dermal dysplasia
p.Pro216= Single submitter tooth agenesis, selective, 4
p.Pro281= Single submitter odonto-onycho-dermal dysplasia
p.Pro302= Single submitter odonto-onycho-dermal dysplasia
p.Pro312= Single submitter tooth agenesis, selective, 4
p.Pro314= Single submitter odonto-onycho-dermal dysplasia
p.Pro322= Single submitter odonto-onycho-dermal dysplasia
p.Pro327= Single submitter odonto-onycho-dermal dysplasia
p.Pro333= Single submitter odonto-onycho-dermal dysplasia
p.Pro350= Single submitter odonto-onycho-dermal dysplasia
p.Pro37= Single submitter odonto-onycho-dermal dysplasia
p.Pro50= Single submitter tooth agenesis, selective, 4
p.Pro53= Single submitter odonto-onycho-dermal dysplasia
p.Ser109= Single submitter tooth agenesis, selective, 4
p.Ser124= Single submitter odonto-onycho-dermal dysplasia
p.Ser130= Single submitter odonto-onycho-dermal dysplasia
p.Ser146= Single submitter odonto-onycho-dermal dysplasia
p.Ser189= Single submitter odonto-onycho-dermal dysplasia
p.Ser202= Single submitter odonto-onycho-dermal dysplasia
p.Ser215= Single submitter odonto-onycho-dermal dysplasia
p.Ser292Gly Single submitter odonto-onycho-dermal dysplasia
p.Ser319= Single submitter odonto-onycho-dermal dysplasia
p.Ser366= Single submitter odonto-onycho-dermal dysplasia
p.Ser369= Single submitter tooth agenesis, selective, 4
p.Ser389= Single submitter tooth agenesis, selective, 4
p.Thr267= Single submitter odonto-onycho-dermal dysplasia
p.Thr275= Single submitter odonto-onycho-dermal dysplasia
p.Thr280= Single submitter odonto-onycho-dermal dysplasia
p.Thr285= Single submitter odonto-onycho-dermal dysplasia
p.Thr285Ala Single submitter Inborn genetic diseases
p.Thr387= Single submitter tooth agenesis, selective, 4
p.Thr59= Single submitter odonto-onycho-dermal dysplasia
p.Val141= Single submitter tooth agenesis, selective, 4
p.Val145= Single submitter odonto-onycho-dermal dysplasia
p.Val192= Single submitter tooth agenesis, selective, 4
p.Val24= Single submitter tooth agenesis, selective, 4
p.Val249Ile Single submitter odonto-onycho-dermal dysplasia ⚠
p.Val254= Single submitter odonto-onycho-dermal dysplasia
p.Val286= Single submitter odonto-onycho-dermal dysplasia
p.Val337= Single submitter odonto-onycho-dermal dysplasia
p.Val402= Single submitter odonto-onycho-dermal dysplasia
p.Val54= Single submitter odonto-onycho-dermal dysplasia
p.Val81= Single submitter odonto-onycho-dermal dysplasia
p.His98= No assertion criteria WNT10A-related disorder

Uncertain significance 179

p.Ala148Val Multiple submitters odonto-onycho-dermal dysplasia ⚠
p.Ala288Thr Multiple submitters Inborn genetic diseases ⚠
p.Ala92Val Multiple submitters odonto-onycho-dermal dysplasia ⚠
p.Arg13Pro Multiple submitters Inborn genetic diseases ⚠
p.Arg176Cys Multiple submitters odonto-onycho-dermal dysplasia
p.Arg223Cys Multiple submitters odonto-onycho-dermal dysplasia ⚠
p.Arg223His Multiple submitters tooth agenesis, selective, 4 ⚠
p.Arg223Ser Multiple submitters Inborn genetic diseases ⚠
p.Arg260Gln Multiple submitters Inborn genetic diseases ⚠
p.Arg305His Multiple submitters odonto-onycho-dermal dysplasia ⚠
p.Arg388Cys Multiple submitters Inborn genetic diseases ⚠
p.Cys394Tyr Multiple submitters odonto-onycho-dermal dysplasia ⚠
p.Cys404Trp Multiple submitters tooth agenesis, selective, 4 ⚠
p.Cys96Arg Multiple submitters ⚠
p.Gln71Leu Multiple submitters tooth agenesis, selective, 4 ⚠
p.Glu347Ala Multiple submitters odonto-onycho-dermal dysplasia ⚠
p.Gly316Arg Multiple submitters Inborn genetic diseases ⚠
p.His143Tyr Multiple submitters odonto-onycho-dermal dysplasia
p.Ile122Phe Multiple submitters odonto-onycho-dermal dysplasia
p.Leu67Pro Multiple submitters Inborn genetic diseases ⚠
p.Lys263Asn Multiple submitters tooth agenesis, selective, 4 ⚠
p.Pro20Gln Multiple submitters odonto-onycho-dermal dysplasia ⚠
p.Pro281Thr Multiple submitters Inborn genetic diseases ⚠
p.Pro350Leu Multiple submitters tooth agenesis, selective, 4 ⚠
p.Pro51Leu Multiple submitters odonto-onycho-dermal dysplasia ⚠
p.Ser146Cys Multiple submitters Inborn genetic diseases ⚠
p.Val81Ala Multiple submitters Inborn genetic diseases ⚠
c.113+3G>A Single submitter odonto-onycho-dermal dysplasia
c.*108G>A Single submitter tooth agenesis, selective, 4
c.*115C>T Single submitter tooth agenesis, selective, 4
c.*139C>G Single submitter tooth agenesis, selective, 4
c.*15C>T Single submitter tooth agenesis, selective, 4
c.*238C>T Single submitter tooth agenesis, selective, 4
c.*339C>T Single submitter tooth agenesis, selective, 4
c.*441C>T Single submitter tooth agenesis, selective, 4
p.Ala137Pro Single submitter ⚠
p.Ala137Thr Single submitter ⚠
p.Ala144Pro Single submitter ⚠
p.Ala161Val Single submitter Inborn genetic diseases ⚠
p.Ala181Val Single submitter odonto-onycho-dermal dysplasia ⚠
p.Ala253Val Single submitter Inborn genetic diseases ⚠
p.Ala317Pro Single submitter Inborn genetic diseases ⚠
p.Ala331Asp Single submitter Inborn genetic diseases ⚠
p.Arg104Pro Single submitter ⚠
p.Arg113Pro Single submitter odonto-onycho-dermal dysplasia
p.Arg11Trp Single submitter Inborn genetic diseases ⚠
p.Arg125Ser Single submitter ⚠
p.Arg163Gln Single submitter odonto-onycho-dermal dysplasia ⚠
p.Arg232Gln Single submitter tooth agenesis, selective, 4 ⚠
p.Arg232Trp Single submitter tooth agenesis, selective, 4 ⚠
p.Arg243Ser Single submitter Inborn genetic diseases ⚠
p.Arg259Trp Single submitter odonto-onycho-dermal dysplasia ⚠
p.Arg284Leu Single submitter ⚠
p.Arg293Cys Single submitter Abnormality of the dentition ⚠
p.Arg305Leu Single submitter tooth agenesis, selective, 4
p.Arg329Ter Single submitter tooth agenesis, selective, 4
p.Arg330dup Single submitter odonto-onycho-dermal dysplasia
p.Arg330Gln Single submitter ⚠
p.Arg330Pro Single submitter Inborn genetic diseases ⚠
p.Arg348Cys Single submitter Abnormality of the dentition ⚠
p.Arg351Leu Single submitter Inborn genetic diseases ⚠
p.Arg385_Gln386insArgGlyArgGlyHisAsnIleLeuArg Single submitter Inborn genetic diseases
p.Arg385His Single submitter odonto-onycho-dermal dysplasia ⚠
p.Arg38Trp Single submitter WNT10A-related disorder ⚠
p.Arg395Cys Single submitter tooth agenesis, selective, 4 ⚠
p.Arg408His Single submitter odonto-onycho-dermal dysplasia ⚠
p.Arg48Cys Single submitter tooth agenesis, selective, 4 ⚠
p.Arg69Gln Single submitter ⚠
p.Arg69Trp Single submitter tooth agenesis, selective, 4
p.Arg70Gln Single submitter Inborn genetic diseases ⚠
p.Arg77His Single submitter Inborn genetic diseases ⚠
p.Arg7Ser Single submitter Inborn genetic diseases ⚠
p.Asn306dup Single submitter tooth agenesis, selective, 4
p.Asn306His Single submitter Inborn genetic diseases ⚠
p.Asn56Asp Single submitter tooth agenesis, selective, 4 ⚠
p.Asp335Ala Single submitter Inborn genetic diseases ⚠
p.Asp370Ala Single submitter Inborn genetic diseases ⚠
p.Cys107Ser Single submitter odonto-onycho-dermal dysplasia ⚠
p.Cys107Tyr Single submitter Inborn genetic diseases ⚠
p.Cys214Arg Single submitter odonto-onycho-dermal dysplasia ⚠
p.Cys264Phe Single submitter tooth agenesis, selective, 4 ⚠
p.Cys276Phe Single submitter ⚠
p.Cys346Arg Single submitter odonto-onycho-dermal dysplasia ⚠
p.Cys362Phe Single submitter odonto-onycho-dermal dysplasia ⚠
p.Cys376Ser Single submitter tooth agenesis, selective, 4 ⚠
p.Cys404Phe Single submitter Inborn genetic diseases ⚠
p.Gln252= Single submitter odonto-onycho-dermal dysplasia
p.Glu167Gln Single submitter ⚠
p.Glu222Lys Single submitter Schöpf-Schulz-Passarge syndrome
p.Glu311Lys Single submitter Inborn genetic diseases
p.Glu390Lys Single submitter ⚠
p.Glu73Lys Single submitter Inborn genetic diseases ⚠
p.Gly185Asp Single submitter odonto-onycho-dermal dysplasia ⚠
p.Gly191Glu Single submitter ⚠
p.Gly307Arg Single submitter odonto-onycho-dermal dysplasia ⚠
p.Gly308Val Single submitter Inborn genetic diseases ⚠
p.Gly313Arg Single submitter ⚠
p.Gly316Ala Single submitter Inborn genetic diseases ⚠
p.Gly323Ser Single submitter Inborn genetic diseases ⚠
p.Gly378_Arg379insSerMetCysCysGly Single submitter odonto-onycho-dermal dysplasia
p.Gly380Ser Single submitter odonto-onycho-dermal dysplasia ⚠
p.Gly88Cys Single submitter tooth agenesis, selective, 4 ⚠
p.Gly88Ser Single submitter tooth agenesis, selective, 4 ⚠
p.His175Tyr Single submitter Inborn genetic diseases ⚠
p.His195Gln Single submitter Inborn genetic diseases ⚠
p.His239Tyr Single submitter Inborn genetic diseases ⚠
p.His98Gln Single submitter Inborn genetic diseases ⚠
p.His98Pro Single submitter Schöpf-Schulz-Passarge syndrome ⚠
p.Ile238Leu Single submitter Inborn genetic diseases ⚠
p.Ile300Phe Single submitter odonto-onycho-dermal dysplasia ⚠
p.Ile44Thr Single submitter ⚠
p.Leu310Arg Single submitter Inborn genetic diseases ⚠
p.Leu384Gln Single submitter ⚠
p.Leu64Phe Single submitter Inborn genetic diseases
p.Lys173Asn Single submitter odonto-onycho-dermal dysplasia ⚠
p.Lys186Thr Single submitter ⚠
p.Met218Arg Single submitter tooth agenesis, selective, 4 ⚠
p.Met375Arg Single submitter tooth agenesis, selective, 4 ⚠
p.Met375Thr Single submitter tooth agenesis, selective, 4 ⚠
p.Met72Ile Single submitter Inborn genetic diseases ⚠
p.Phe224Leu Single submitter odonto-onycho-dermal dysplasia ⚠
p.Phe224Ser Single submitter ⚠
p.Phe228Leu Single submitter ⚠
p.Phe27Ile Single submitter Inborn genetic diseases ⚠
p.Phe294Val Single submitter Inborn genetic diseases ⚠
p.Phe339Leu Single submitter Inborn genetic diseases ⚠
p.Phe345Leu Single submitter tooth agenesis, selective, 4 ⚠
p.Pro117Ser Single submitter tooth agenesis, selective, 4 ⚠
p.Pro18Leu Single submitter Inborn genetic diseases ⚠
p.Pro318His Single submitter Inborn genetic diseases ⚠
p.Pro320Arg Single submitter odonto-onycho-dermal dysplasia ⚠
p.Pro320Ser Single submitter Inborn genetic diseases ⚠
p.Pro327Gln Single submitter ⚠
p.Pro51Arg Single submitter ⚠
p.Ser108Leu Single submitter odonto-onycho-dermal dysplasia ⚠
p.Ser124Gly Single submitter Inborn genetic diseases ⚠
p.Ser208Phe Single submitter tooth agenesis, selective, 4 ⚠
p.Ser215Arg Single submitter ⚠
p.Ser231Phe Single submitter Inborn genetic diseases ⚠
p.Ser268Pro Single submitter Inborn genetic diseases ⚠
p.Ser354Leu Single submitter tooth agenesis, selective, 4 ⚠
p.Ser366Arg Single submitter Inborn genetic diseases ⚠
p.Ser3Cys Single submitter tooth agenesis, selective, 4 ⚠
p.Thr200Arg Single submitter Inborn genetic diseases ⚠
p.Thr275Ala Single submitter ⚠
p.Thr280Met Single submitter tooth agenesis, selective, 4 ⚠
p.Thr280Ser Single submitter tooth agenesis, selective, 4 ⚠
p.Trp105Cys Single submitter tooth agenesis, selective, 4 ⚠
p.Val142del Single submitter
p.Val145Ala Single submitter tooth agenesis, selective, 4 ⚠
p.Val402Met Single submitter tooth agenesis, selective, 4 ⚠
p.Val54Met Single submitter Inborn genetic diseases ⚠
p.Ala4Thr No assertion criteria Schöpf-Schulz-Passarge syndrome ⚠
p.Ala4Val No assertion criteria Schöpf-Schulz-Passarge syndrome ⚠
p.Arg104Ser No assertion criteria tooth agenesis, selective, 4 ⚠
p.Arg260Trp No assertion criteria Schöpf-Schulz-Passarge syndrome ⚠
p.Arg328_Pro333del No assertion criteria Schöpf-Schulz-Passarge syndrome
p.Arg328Cys No assertion criteria Schöpf-Schulz-Passarge syndrome ⚠
p.Arg348Ser No assertion criteria Schöpf-Schulz-Passarge syndrome ⚠
p.Cys376Phe No assertion criteria tooth agenesis, selective, 4 ⚠
p.Gln278= No assertion criteria Schöpf-Schulz-Passarge syndrome
p.Gln386His No assertion criteria Schöpf-Schulz-Passarge syndrome ⚠
p.Gly308Ser No assertion criteria Schöpf-Schulz-Passarge syndrome ⚠
p.Gly356Ala No assertion criteria Schöpf-Schulz-Passarge syndrome ⚠
p.Gly380_His381insAlaAla No assertion criteria odonto-onycho-dermal dysplasia
p.His98Tyr No assertion criteria Schöpf-Schulz-Passarge syndrome ⚠
p.Leu10Arg No assertion criteria Schöpf-Schulz-Passarge syndrome ⚠
p.Leu154Met No assertion criteria WNT10A-related disorder ⚠
p.Leu299Arg No assertion criteria Schöpf-Schulz-Passarge syndrome ⚠
p.Leu55Phe No assertion criteria Schöpf-Schulz-Passarge syndrome ⚠
p.Pro117Arg No assertion criteria Schöpf-Schulz-Passarge syndrome ⚠
p.Pro314Gln No assertion criteria Schöpf-Schulz-Passarge syndrome ⚠
p.Pro325Leu No assertion criteria Schöpf-Schulz-Passarge syndrome ⚠
p.Pro37Ser No assertion criteria Schöpf-Schulz-Passarge syndrome ⚠
p.Pro41Leu No assertion criteria Schöpf-Schulz-Passarge syndrome ⚠
p.Pro65Leu No assertion criteria Schöpf-Schulz-Passarge syndrome ⚠
p.Ser130Arg No assertion criteria WNT10A-related disorder ⚠
p.Ser332= No assertion criteria Schöpf-Schulz-Passarge syndrome
p.Val279Gly No assertion criteria Schöpf-Schulz-Passarge syndrome ⚠