Sugi Variant

Sugi Variant/WNT9B

WNT9B — 105 ClinVar variants

All ClinVar germline WNT9B variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 61 flagged for review →

2 Likely pathogenic · 1 Conflicting · 17 Benign · 2 Benign/Likely benign · 21 Likely benign · 62 Uncertain significance

Full WNT9B gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions

⚑ Evidence disagreements 61

Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.

Predictors agree, ClinVar conflicts 1

ClinVar submitters conflict, but the independent predictors unanimously agree — a QC review flag, not a reclassification.

Predictors lean, ClinVar uncertain 45

ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.

Predictors split 15

The independent predictors disagree with each other — read with care.

All WNT9B variants

Likely pathogenic 2

  • p.Gly317Arg No assertion criteria Cystic renal dysplasia
  • p.Pro5fs No assertion criteria renal dysplasia

Conflicting classifications of pathogenicity 1

Benign 17

Benign/Likely benign 2

Likely benign 21

Uncertain significance 62