Sugi Variant

Sugi Variant/WRN

WRN — 3625 ClinVar variants

All ClinVar germline WRN variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 1629 flagged for review →

216 Pathogenic · 52 Pathogenic/Likely pathogenic · 145 Likely pathogenic · 84 Conflicting · 105 Benign · 33 Benign/Likely benign · 1127 Likely benign · 1863 Uncertain significance

Full WRN gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions

⚑ Evidence disagreements 1629

Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.

Predictors vs ClinVar 4

ClinVar calls these pathogenic, but the computational predictors lean tolerated — the highest-value review flag.

Predictors agree, ClinVar conflicts 46

ClinVar submitters conflict, but the independent predictors unanimously agree — a QC review flag, not a reclassification.

Predictors lean, ClinVar uncertain 1315

ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification. · showing the 150 best-reviewed of 1315

Predictors split 264

The independent predictors disagree with each other — read with care. · showing the 150 best-reviewed of 264

All WRN variants

Pathogenic 216

Pathogenic/Likely pathogenic 52

Likely pathogenic 145

Conflicting classifications of pathogenicity 84

Benign 105

Benign/Likely benign 33

Likely benign 1127

Showing the top 300 by review status; the full set is in the sitemap.

Uncertain significance 1863

Showing the top 300 by review status; the full set is in the sitemap.