XPO7 — 49 ClinVar variants
All ClinVar germline XPO7 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 47 flagged for review →
1 Benign · 48 Uncertain significance
Full XPO7 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 47
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 36
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- XPO7 p.Ala133Val Uncertain significance Single submitter
- XPO7 p.Ala481Ser Uncertain significance Single submitter
- XPO7 p.Ala502Ser Uncertain significance Single submitter
- XPO7 p.Ala730Thr Uncertain significance Single submitter
- XPO7 p.Arg537His Uncertain significance Single submitter
- XPO7 p.Arg574His Uncertain significance Single submitter
- XPO7 p.Arg674His Uncertain significance Single submitter
- XPO7 p.Arg800Gln Uncertain significance Single submitter
- XPO7 p.Arg812Cys Uncertain significance Single submitter
- XPO7 p.Arg967His Uncertain significance Single submitter
- XPO7 p.Asn1083Asp Uncertain significance Single submitter
- XPO7 p.Asn326Ser Uncertain significance Single submitter
- XPO7 p.Asn351Lys Uncertain significance Single submitter
- XPO7 p.Asn543Asp Uncertain significance Single submitter
- XPO7 p.Asn641Lys Uncertain significance Single submitter
- XPO7 p.Asn642Ser Uncertain significance Single submitter
- XPO7 p.Asn708Ser Uncertain significance Single submitter
- XPO7 p.Asn863Ser Uncertain significance Single submitter
- XPO7 p.Asp188Glu Uncertain significance Single submitter
- XPO7 p.Gln440His Uncertain significance Single submitter
- XPO7 p.Glu210Gly Uncertain significance Single submitter
- XPO7 p.Gly437Ala Uncertain significance Single submitter
- XPO7 p.Ile287Met Uncertain significance Single submitter
- XPO7 p.Ile593Val Uncertain significance Single submitter
- XPO7 p.Ile609Val Uncertain significance Single submitter
- XPO7 p.Ile758Val Uncertain significance Single submitter
- XPO7 p.Ile834Ser Uncertain significance Single submitter
- XPO7 p.Lys773Thr Uncertain significance Single submitter
- XPO7 p.Pro77Arg Uncertain significance Single submitter
- XPO7 p.Pro960Ser Uncertain significance Single submitter
- XPO7 p.Ser1082Asn Uncertain significance Single submitter
- XPO7 p.Ser468Ala Uncertain significance Single submitter
- XPO7 p.Thr102Ala Uncertain significance Single submitter
- XPO7 p.Thr737Ser Uncertain significance Single submitter
- XPO7 p.Val1080Met Uncertain significance Single submitter
- XPO7 p.Val246Met Uncertain significance Single submitter
Predictors split 11
The independent predictors disagree with each other — read with care.
- XPO7 p.Arg812Ser Uncertain significance Single submitter
- XPO7 p.His647Gln Uncertain significance Single submitter
- XPO7 p.Ile500Thr Uncertain significance Single submitter
- XPO7 p.Leu908Val Uncertain significance Single submitter
- XPO7 p.Met1035Thr Uncertain significance Single submitter
- XPO7 p.Phe731Leu Uncertain significance Single submitter
- XPO7 p.Phe904Leu Uncertain significance Single submitter
- XPO7 p.Phe992Ile Uncertain significance Single submitter
- XPO7 p.Ser738Arg Uncertain significance Single submitter
- XPO7 p.Ser837Cys Uncertain significance Single submitter
- XPO7 p.Val308Ala Uncertain significance Single submitter
All XPO7 variants
Benign 1
- p.Phe103= Single submitter
Uncertain significance 48
- p.Ala133Val Single submitter ⚠
- p.Ala481Ser Single submitter ⚠
- p.Ala502Ser Single submitter ⚠
- p.Ala730Thr Single submitter ⚠
- p.Arg537His Single submitter ⚠
- p.Arg574His Single submitter ⚠
- p.Arg674His Single submitter ⚠
- p.Arg800Gln Single submitter ⚠
- p.Arg812Cys Single submitter ⚠
- p.Arg812Ser Single submitter ⚠
- p.Arg967His Single submitter ⚠
- p.Asn1083Asp Single submitter ⚠
- p.Asn326Ser Single submitter ⚠
- p.Asn351Lys Single submitter ⚠
- p.Asn543Asp Single submitter ⚠
- p.Asn641Lys Single submitter ⚠
- p.Asn642Ser Single submitter ⚠
- p.Asn708Ser Single submitter ⚠
- p.Asn863Ser Single submitter ⚠
- p.Asp188Glu Single submitter ⚠
- p.Gln440His Single submitter ⚠
- p.Glu210Gly Single submitter ⚠
- p.Glu744Gly Single submitter
- p.Gly437Ala Single submitter ⚠
- p.His647Gln Single submitter ⚠
- p.Ile287Met Single submitter ⚠
- p.Ile500Thr Single submitter ⚠
- p.Ile593Val Single submitter ⚠
- p.Ile609Val Single submitter ⚠
- p.Ile758Val Single submitter ⚠
- p.Ile834Ser Single submitter ⚠
- p.Leu908Val Single submitter ⚠
- p.Lys773Thr Single submitter ⚠
- p.Met1035Thr Single submitter ⚠
- p.Phe731Leu Single submitter ⚠
- p.Phe904Leu Single submitter ⚠
- p.Phe992Ile Single submitter ⚠
- p.Pro77Arg Single submitter ⚠
- p.Pro960Ser Single submitter ⚠
- p.Ser1082Asn Single submitter ⚠
- p.Ser468Ala Single submitter ⚠
- p.Ser738Arg Single submitter ⚠
- p.Ser837Cys Single submitter ⚠
- p.Thr102Ala Single submitter ⚠
- p.Thr737Ser Single submitter ⚠
- p.Val1080Met Single submitter ⚠
- p.Val246Met Single submitter ⚠
- p.Val308Ala Single submitter ⚠