XRCC5 — 65 ClinVar variants
All ClinVar germline XRCC5 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 53 flagged for review →
2 Benign · 1 Benign/Likely benign · 7 Likely benign · 55 Uncertain significance
Full XRCC5 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 53
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 45
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- XRCC5 p.Arg184Gly Uncertain significance Single submitter
- XRCC5 p.Arg599His Uncertain significance Single submitter
- XRCC5 p.Arg654His Uncertain significance Single submitter
- XRCC5 p.Asn517Ser Uncertain significance Single submitter
- XRCC5 p.Asp173Tyr Uncertain significance Single submitter
- XRCC5 p.Asp222Gly Uncertain significance Single submitter
- XRCC5 p.Asp280His Uncertain significance Single submitter
- XRCC5 p.Asp299His Uncertain significance Single submitter
- XRCC5 p.Cys235Arg Uncertain significance Single submitter
- XRCC5 p.Gln527Glu Uncertain significance Single submitter
- XRCC5 p.Gln653Arg Uncertain significance Single submitter
- XRCC5 p.Glu474Val Uncertain significance Single submitter
- XRCC5 p.Glu621Lys Uncertain significance Single submitter
- XRCC5 p.Glu664Gln Uncertain significance Single submitter
- XRCC5 p.Gly572Arg Uncertain significance Single submitter
- XRCC5 p.His188Leu Uncertain significance Single submitter
- XRCC5 p.Ile134Met Uncertain significance Single submitter
- XRCC5 p.Ile224Met Uncertain significance Single submitter
- XRCC5 p.Ile24Leu Uncertain significance Single submitter
- XRCC5 p.Ile647Val Uncertain significance Single submitter
- XRCC5 p.Ile686Val Uncertain significance Single submitter
- XRCC5 p.Leu387Val Uncertain significance Single submitter
- XRCC5 p.Leu473Phe Uncertain significance Single submitter
- XRCC5 p.Leu476Trp Uncertain significance Single submitter
- XRCC5 p.Lys443Arg Uncertain significance Single submitter
- XRCC5 p.Lys606Glu Uncertain significance Single submitter
- XRCC5 p.Lys606Thr Uncertain significance Single submitter
- XRCC5 p.Met14Val Uncertain significance Single submitter
- XRCC5 p.Met427Leu Uncertain significance Single submitter
- XRCC5 p.Met434Val Uncertain significance Single submitter
- XRCC5 p.Pro25Ser Uncertain significance Single submitter
- XRCC5 p.Pro507Ala Uncertain significance Single submitter
- XRCC5 p.Pro711Gln Uncertain significance Single submitter
- XRCC5 p.Ser102Cys Uncertain significance Single submitter
- XRCC5 p.Ser139Arg Uncertain significance Single submitter
- XRCC5 p.Ser168Leu Uncertain significance Single submitter
- XRCC5 p.Ser608Asn Uncertain significance Single submitter
- XRCC5 p.Thr472Ser Uncertain significance Single submitter
- XRCC5 p.Thr563Arg Uncertain significance Single submitter
- XRCC5 p.Thr715Ile Uncertain significance Single submitter
- XRCC5 p.Thr78Ile Uncertain significance Single submitter
- XRCC5 p.Val236Ile Uncertain significance Single submitter
- XRCC5 p.Val407Met Uncertain significance Single submitter
- XRCC5 p.Val420Ala Uncertain significance Single submitter
- XRCC5 p.Val578Leu Uncertain significance Single submitter
Predictors split 8
The independent predictors disagree with each other — read with care.
- XRCC5 p.Arg431Gln Uncertain significance Single submitter
- XRCC5 p.Arg643Gln Uncertain significance Single submitter
- XRCC5 p.Asp467Gly Uncertain significance Single submitter
- XRCC5 p.Gly204Arg Uncertain significance Single submitter
- XRCC5 p.Gly590Glu Uncertain significance Single submitter
- XRCC5 p.Phe107Leu Uncertain significance Single submitter
- XRCC5 p.Phe356Leu Uncertain significance Single submitter
- XRCC5 p.Pro630Leu Likely benign Single submitter
All XRCC5 variants
Benign/Likely benign 1
- p.Phe340= No assertion criteria
Likely benign 7
- p.Ala550Ser Single submitter
- p.Ala612Val Single submitter
- p.Asn452Ser Single submitter
- p.Gly406= Single submitter
- p.Pro630Leu Single submitter ⚠
- p.Thr447= Single submitter
- p.Thr524Ala Single submitter
Uncertain significance 55
- c.492-1G>A Single submitter
- p.Arg184Gly Single submitter ⚠
- p.Arg431Gln Single submitter ⚠
- p.Arg44Ter Single submitter
- p.Arg599His Single submitter ⚠
- p.Arg643Gln Single submitter ⚠
- p.Arg654His Single submitter ⚠
- p.Asn517Ser Single submitter ⚠
- p.Asp173Tyr Single submitter ⚠
- p.Asp222Gly Single submitter ⚠
- p.Asp280His Single submitter ⚠
- p.Asp299His Single submitter ⚠
- p.Asp467Gly Single submitter ⚠
- p.Cys235Arg Single submitter ⚠
- p.Gln527Glu Single submitter ⚠
- p.Gln653Arg Single submitter ⚠
- p.Glu474Val Single submitter ⚠
- p.Glu621Lys Single submitter ⚠
- p.Glu664Gln Single submitter ⚠
- p.Gly204Arg Single submitter ⚠
- p.Gly572Arg Single submitter ⚠
- p.Gly590Glu Single submitter ⚠
- p.His188Leu Single submitter ⚠
- p.Ile134Met Single submitter ⚠
- p.Ile224Met Single submitter ⚠
- p.Ile24Leu Single submitter ⚠
- p.Ile647Val Single submitter ⚠
- p.Ile686Val Single submitter ⚠
- p.Leu387Val Single submitter ⚠
- p.Leu473Phe Single submitter ⚠
- p.Leu476Trp Single submitter ⚠
- p.Lys443Arg Single submitter ⚠
- p.Lys606Glu Single submitter ⚠
- p.Lys606Thr Single submitter ⚠
- p.Met14Val Single submitter ⚠
- p.Met427Leu Single submitter ⚠
- p.Met434Val Single submitter ⚠
- p.Phe107Leu Single submitter ⚠
- p.Phe356Leu Single submitter ⚠
- p.Pro25Ser Single submitter ⚠
- p.Pro507Ala Single submitter ⚠
- p.Pro711Gln Single submitter ⚠
- p.Ser102Cys Single submitter ⚠
- p.Ser139Arg Single submitter ⚠
- p.Ser168Leu Single submitter ⚠
- p.Ser608Asn Single submitter ⚠
- p.Thr472Ser Single submitter ⚠
- p.Thr563Arg Single submitter ⚠
- p.Thr715Ile Single submitter ⚠
- p.Thr78Ile Single submitter ⚠
- p.Val236Ile Single submitter ⚠
- p.Val375Gly Single submitter
- p.Val407Met Single submitter ⚠
- p.Val420Ala Single submitter ⚠
- p.Val578Leu Single submitter ⚠