XRCC6 — 48 ClinVar variants
All ClinVar germline XRCC6 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 40 flagged for review →
2 Benign · 5 Likely benign · 41 Uncertain significance
Full XRCC6 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 40
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 31
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- XRCC6 p.Ala44Val Uncertain significance Single submitter
- XRCC6 p.Ala513Thr Uncertain significance Single submitter
- XRCC6 p.Arg130Ser Uncertain significance Single submitter
- XRCC6 p.Arg404Met Uncertain significance Single submitter
- XRCC6 p.Arg586Gln Uncertain significance Single submitter
- XRCC6 p.Asn178Ser Uncertain significance Single submitter
- XRCC6 p.Asn304Ser Uncertain significance Single submitter
- XRCC6 p.Gln158His Uncertain significance Single submitter
- XRCC6 p.Gly191Cys Uncertain significance Single submitter
- XRCC6 p.Gly191Ser Uncertain significance Single submitter
- XRCC6 p.His232Pro Uncertain significance Single submitter
- XRCC6 p.Ile220Thr Uncertain significance Single submitter
- XRCC6 p.Ile223Thr Uncertain significance Single submitter
- XRCC6 p.Ile267Met Uncertain significance Single submitter
- XRCC6 p.Ile387Leu Uncertain significance Single submitter
- XRCC6 p.Leu143Phe Uncertain significance Single submitter
- XRCC6 p.Leu390Met Uncertain significance Single submitter
- XRCC6 p.Met134Val Uncertain significance Single submitter
- XRCC6 p.Met167Thr Uncertain significance Single submitter
- XRCC6 p.Met446Ile Uncertain significance Single submitter
- XRCC6 p.Met514Val Uncertain significance Single submitter
- XRCC6 p.Phe87Val Uncertain significance Single submitter
- XRCC6 p.Pro500Ala Uncertain significance Single submitter
- XRCC6 p.Ser475Asn Uncertain significance Single submitter
- XRCC6 p.Thr188Ala Uncertain significance Single submitter
- XRCC6 p.Thr334Ala Uncertain significance Single submitter
- XRCC6 p.Tyr559His Uncertain significance Single submitter
- XRCC6 p.Val368Met Uncertain significance Single submitter
- XRCC6 p.Val466Ile Uncertain significance Single submitter
- XRCC6 p.Val482Met Uncertain significance Single submitter
- XRCC6 p.Val557Leu Uncertain significance Single submitter
Predictors split 9
The independent predictors disagree with each other — read with care.
- XRCC6 p.Arg187Ser Uncertain significance Single submitter
- XRCC6 p.Arg586Trp Uncertain significance Single submitter
- XRCC6 p.Asn98Thr Uncertain significance Single submitter
- XRCC6 p.Glu562Val Uncertain significance Single submitter
- XRCC6 p.His176Asn Uncertain significance Single submitter
- XRCC6 p.Leu193Ile Uncertain significance Single submitter
- XRCC6 p.Leu310Phe Uncertain significance Single submitter
- XRCC6 p.Tyr71Cys Uncertain significance Single submitter
- XRCC6 p.Val146Met Uncertain significance Single submitter
All XRCC6 variants
Benign 2
- c.960+10G>A Multiple submitters
- c.-16+5G>A Single submitter
Likely benign 5
- p.Asn264Ser Single submitter
- p.Glu91Lys Single submitter
- p.Ile387Thr Single submitter
- p.Met348Ile Single submitter
- p.Ser73Asn Single submitter
Uncertain significance 41
- p.Ala44Val Single submitter ⚠
- p.Ala513Thr Single submitter ⚠
- p.Arg130Ser Single submitter ⚠
- p.Arg187Ser Single submitter ⚠
- p.Arg404Met Single submitter ⚠
- p.Arg586Gln Single submitter ⚠
- p.Arg586Trp Single submitter ⚠
- p.Asn178Ser Single submitter ⚠
- p.Asn304Ser Single submitter ⚠
- p.Asn98Thr Single submitter ⚠
- p.Gln158His Single submitter ⚠
- p.Glu562Val Single submitter ⚠
- p.Gly191Cys Single submitter ⚠
- p.Gly191Ser Single submitter ⚠
- p.His176Asn Single submitter ⚠
- p.His232Pro Single submitter ⚠
- p.Ile220Thr Single submitter ⚠
- p.Ile223Thr Single submitter ⚠
- p.Ile267Met Single submitter ⚠
- p.Ile387Leu Single submitter ⚠
- p.Leu143Phe Single submitter ⚠
- p.Leu193Ile Single submitter ⚠
- p.Leu310Phe Single submitter ⚠
- p.Leu390Met Single submitter ⚠
- p.Met134Val Single submitter ⚠
- p.Met167Thr Single submitter ⚠
- p.Met446Ile Single submitter ⚠
- p.Met514Val Single submitter ⚠
- p.Phe87Val Single submitter ⚠
- p.Pro352Gln Single submitter
- p.Pro500Ala Single submitter ⚠
- p.Ser475Asn Single submitter ⚠
- p.Thr188Ala Single submitter ⚠
- p.Thr334Ala Single submitter ⚠
- p.Tyr559His Single submitter ⚠
- p.Tyr71Cys Single submitter ⚠
- p.Val146Met Single submitter ⚠
- p.Val368Met Single submitter ⚠
- p.Val466Ile Single submitter ⚠
- p.Val482Met Single submitter ⚠
- p.Val557Leu Single submitter ⚠