XRN2 — 90 ClinVar variants
All ClinVar germline XRN2 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 80 flagged for review →
1 Benign · 2 Likely benign · 87 Uncertain significance
Full XRN2 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 80
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 64
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- XRN2 p.Ala297Val Uncertain significance Single submitter
- XRN2 p.Ala442Pro Uncertain significance Single submitter
- XRN2 p.Ala648Pro Uncertain significance Single submitter
- XRN2 p.Ala834Gly Uncertain significance Single submitter
- XRN2 p.Ala887Gly Uncertain significance Single submitter
- XRN2 p.Arg181His Uncertain significance Single submitter
- XRN2 p.Arg281Lys Uncertain significance Single submitter
- XRN2 p.Arg305Gln Uncertain significance Single submitter
- XRN2 p.Arg362Cys Uncertain significance Single submitter
- XRN2 p.Arg615Gln Uncertain significance Single submitter
- XRN2 p.Arg793Gln Uncertain significance Single submitter
- XRN2 p.Arg803Cys Uncertain significance Single submitter
- XRN2 p.Arg824Gly Uncertain significance Single submitter
- XRN2 p.Arg922Gln Uncertain significance Single submitter
- XRN2 p.Arg936Lys Uncertain significance Single submitter
- XRN2 p.Asn30Asp Uncertain significance Single submitter
- XRN2 p.Asn469Ser Uncertain significance Single submitter
- XRN2 p.Asn802His Uncertain significance Single submitter
- XRN2 p.Asn833Ser Uncertain significance Single submitter
- XRN2 p.Asp580His Uncertain significance Single submitter
- XRN2 p.Asp725Glu Uncertain significance Single submitter
- XRN2 p.Asp725Val Uncertain significance Single submitter
- XRN2 p.Cys266Tyr Uncertain significance Single submitter
- XRN2 p.Cys296Phe Uncertain significance Single submitter
- XRN2 p.Glu153Gln Uncertain significance Single submitter
- XRN2 p.Glu664Gly Uncertain significance Single submitter
- XRN2 p.His716Arg Uncertain significance Single submitter
- XRN2 p.Ile492Val Uncertain significance Single submitter
- XRN2 p.Ile81Ser Uncertain significance Single submitter
- XRN2 p.Leu294Phe Uncertain significance Single submitter
- XRN2 p.Leu724Met Uncertain significance Single submitter
- XRN2 p.Leu859Val Uncertain significance Single submitter
- XRN2 p.Lys123Glu Uncertain significance Single submitter
- XRN2 p.Lys259Arg Uncertain significance Single submitter
- XRN2 p.Lys284Thr Uncertain significance Single submitter
- XRN2 p.Met466Ile Uncertain significance Single submitter
- XRN2 p.Met741Val Uncertain significance Single submitter
- XRN2 p.Met860Arg Uncertain significance Single submitter
- XRN2 p.Met860Leu Uncertain significance Single submitter
- XRN2 p.Met896Leu Uncertain significance Single submitter
- XRN2 p.Phe269Tyr Uncertain significance Single submitter
- XRN2 p.Pro246Leu Uncertain significance Single submitter
- XRN2 p.Pro280Ala Uncertain significance Single submitter
- XRN2 p.Pro323Arg Uncertain significance Single submitter
- XRN2 p.Pro449Ser Uncertain significance Single submitter
- XRN2 p.Pro457Leu Uncertain significance Single submitter
- XRN2 p.Pro472Ser Uncertain significance Single submitter
- XRN2 p.Pro505Leu Uncertain significance Single submitter
- XRN2 p.Pro591Leu Uncertain significance Single submitter
- XRN2 p.Pro712Ser Uncertain significance Single submitter
- XRN2 p.Pro838Leu Uncertain significance Single submitter
- XRN2 p.Pro889Leu Uncertain significance Single submitter
- XRN2 p.Pro919Ala Uncertain significance Single submitter
- XRN2 p.Ser16Thr Uncertain significance Single submitter
- XRN2 p.Ser455Thr Uncertain significance Single submitter
- XRN2 p.Ser473Ala Uncertain significance Single submitter
- XRN2 p.Ser475Pro Uncertain significance Single submitter
- XRN2 p.Ser485Cys Uncertain significance Single submitter
- XRN2 p.Ser541Leu Uncertain significance Single submitter
- XRN2 p.Ser619Asn Uncertain significance Single submitter
- XRN2 p.Thr478Met Uncertain significance Single submitter
- XRN2 p.Tyr176Cys Uncertain significance Single submitter
- XRN2 p.Tyr84Ser Uncertain significance Single submitter
- XRN2 p.Val885Phe Uncertain significance Single submitter
Predictors split 16
The independent predictors disagree with each other — read with care.
- XRN2 p.Arg134Gln Uncertain significance Single submitter
- XRN2 p.Arg175Cys Uncertain significance Single submitter
- XRN2 p.Arg362His Uncertain significance Single submitter
- XRN2 p.Cys547Ser Likely benign Single submitter
- XRN2 p.Gly376Cys Uncertain significance Single submitter
- XRN2 p.Ile237Val Uncertain significance Single submitter
- XRN2 p.Ile366Met Uncertain significance Single submitter
- XRN2 p.Ile718Thr Uncertain significance Single submitter
- XRN2 p.Lys522Asn Uncertain significance Single submitter
- XRN2 p.Met391Ile Uncertain significance Single submitter
- XRN2 p.Met464Ile Uncertain significance Single submitter
- XRN2 p.Pro219Thr Uncertain significance Single submitter
- XRN2 p.Ser402Arg Uncertain significance Single submitter
- XRN2 p.Thr225Ile Uncertain significance Single submitter
- XRN2 p.Thr374Ser Uncertain significance Single submitter
- XRN2 p.Tyr642His Uncertain significance Single submitter
All XRN2 variants
Benign 1
- p.Val336Ile Single submitter
Likely benign 2
- p.Cys547Ser Single submitter ⚠
- p.Ile729Val Single submitter
Uncertain significance 87
- p.Ala297Val Single submitter ⚠
- p.Ala442Pro Single submitter ⚠
- p.Ala648Pro Single submitter ⚠
- p.Ala648Ser Single submitter
- p.Ala834Gly Single submitter ⚠
- p.Ala887Gly Single submitter ⚠
- p.Arg134Gln Single submitter ⚠
- p.Arg175Cys Single submitter ⚠
- p.Arg181His Single submitter ⚠
- p.Arg281Lys Single submitter ⚠
- p.Arg305Gln Single submitter ⚠
- p.Arg362Cys Single submitter ⚠
- p.Arg362His Single submitter ⚠
- p.Arg615Gln Single submitter ⚠
- p.Arg615Trp Single submitter
- p.Arg793Gln Single submitter ⚠
- p.Arg803Cys Single submitter ⚠
- p.Arg805Trp Single submitter
- p.Arg824Gly Single submitter ⚠
- p.Arg922Gln Single submitter ⚠
- p.Arg936Lys Single submitter ⚠
- p.Asn183Asp Single submitter
- p.Asn224Asp Single submitter
- p.Asn30Asp Single submitter ⚠
- p.Asn469Ser Single submitter ⚠
- p.Asn802His Single submitter ⚠
- p.Asn833Ser Single submitter ⚠
- p.Asp580His Single submitter ⚠
- p.Asp725Glu Single submitter ⚠
- p.Asp725Val Single submitter ⚠
- p.Cys266Tyr Single submitter ⚠
- p.Cys296Phe Single submitter ⚠
- p.Glu153Gln Single submitter ⚠
- p.Glu664Gly Single submitter ⚠
- p.Gly376Cys Single submitter ⚠
- p.Gly436Arg Single submitter
- p.His716Arg Single submitter ⚠
- p.Ile237Val Single submitter ⚠
- p.Ile366Met Single submitter ⚠
- p.Ile492Val Single submitter ⚠
- p.Ile718Thr Single submitter ⚠
- p.Ile81Ser Single submitter ⚠
- p.Leu294Phe Single submitter ⚠
- p.Leu724Met Single submitter ⚠
- p.Leu859Val Single submitter ⚠
- p.Lys123Glu Single submitter ⚠
- p.Lys259Arg Single submitter ⚠
- p.Lys284Thr Single submitter ⚠
- p.Lys522Asn Single submitter ⚠
- p.Met319Val Single submitter
- p.Met391Ile Single submitter ⚠
- p.Met464Ile Single submitter ⚠
- p.Met466Ile Single submitter ⚠
- p.Met741Val Single submitter ⚠
- p.Met860Arg Single submitter ⚠
- p.Met860Leu Single submitter ⚠
- p.Met896Leu Single submitter ⚠
- p.Phe269Tyr Single submitter ⚠
- p.Pro219Thr Single submitter ⚠
- p.Pro246Leu Single submitter ⚠
- p.Pro280Ala Single submitter ⚠
- p.Pro323Arg Single submitter ⚠
- p.Pro449Ser Single submitter ⚠
- p.Pro457Leu Single submitter ⚠
- p.Pro472Ser Single submitter ⚠
- p.Pro505Leu Single submitter ⚠
- p.Pro591Leu Single submitter ⚠
- p.Pro712Ser Single submitter ⚠
- p.Pro838Leu Single submitter ⚠
- p.Pro889Leu Single submitter ⚠
- p.Pro919Ala Single submitter ⚠
- p.Ser16Thr Single submitter ⚠
- p.Ser402Arg Single submitter ⚠
- p.Ser455Thr Single submitter ⚠
- p.Ser473Ala Single submitter ⚠
- p.Ser475Pro Single submitter ⚠
- p.Ser485Cys Single submitter ⚠
- p.Ser541Leu Single submitter ⚠
- p.Ser619Asn Single submitter ⚠
- p.Thr225Ile Single submitter ⚠
- p.Thr374Ser Single submitter ⚠
- p.Thr478Met Single submitter ⚠
- p.Thr670Ile Single submitter
- p.Tyr176Cys Single submitter ⚠
- p.Tyr642His Single submitter ⚠
- p.Tyr84Ser Single submitter ⚠
- p.Val885Phe Single submitter ⚠