YBX1 — 23 ClinVar variants
All ClinVar germline YBX1 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 19 flagged for review →
1 Benign · 3 Likely benign · 19 Uncertain significance
Full YBX1 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 19
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 11
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- YBX1 p.Ala323Thr Uncertain significance Single submitter
- YBX1 p.Arg151Leu Uncertain significance Single submitter
- YBX1 p.Arg279His Uncertain significance Single submitter
- YBX1 p.Arg97Trp Uncertain significance Single submitter
- YBX1 p.Asn171Asp Uncertain significance Single submitter
- YBX1 p.Asn210Thr Uncertain significance Single submitter
- YBX1 p.Glu179Asp Uncertain significance Single submitter
- YBX1 p.Gly127Arg Uncertain significance Single submitter
- YBX1 p.Gly225Ser Uncertain significance Single submitter
- YBX1 p.Gly259Ser Uncertain significance Single submitter
- YBX1 p.Pro277Ser Uncertain significance Single submitter
Predictors split 8
The independent predictors disagree with each other — read with care.
- YBX1 p.Arg152Gly Uncertain significance Single submitter
- YBX1 p.Arg156Cys Uncertain significance Single submitter
- YBX1 p.Arg239Leu Uncertain significance Single submitter
- YBX1 p.Arg246Leu Uncertain significance Single submitter
- YBX1 p.Arg69Gly Uncertain significance Single submitter
- YBX1 p.Gly300Val Uncertain significance Single submitter
- YBX1 p.Ile91Val Uncertain significance Single submitter
- YBX1 p.Met198Ile Uncertain significance Single submitter
All YBX1 variants
Benign 1
- p.Gly227Val No assertion criteria YBX1-related disorder
Likely benign 3
Uncertain significance 19
- p.Ala323Thr Single submitter ⚠
- p.Arg151Leu Single submitter ⚠
- p.Arg152Gly Single submitter ⚠
- p.Arg156Cys Single submitter ⚠
- p.Arg239Leu Single submitter ⚠
- p.Arg246Leu Single submitter ⚠
- p.Arg279His Single submitter ⚠
- p.Arg69Gly Single submitter ⚠
- p.Arg97Trp Single submitter ⚠
- p.Asn171Asp Single submitter ⚠
- p.Asn210Thr Single submitter ⚠
- p.Glu179Asp Single submitter ⚠
- p.Gly127Arg Single submitter ⚠
- p.Gly225Ser Single submitter ⚠
- p.Gly259Ser Single submitter ⚠
- p.Gly300Val Single submitter ⚠
- p.Ile91Val Single submitter ⚠
- p.Met198Ile Single submitter ⚠
- p.Pro277Ser Single submitter ⚠