YBX3 — 75 ClinVar variants
All ClinVar germline YBX3 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 72 flagged for review →
2 Likely benign · 73 Uncertain significance
Full YBX3 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 72
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 52
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- YBX3 p.Ala154Val Uncertain significance Single submitter
- YBX3 p.Ala193Thr Uncertain significance Single submitter
- YBX3 p.Ala219Ser Uncertain significance Single submitter
- YBX3 p.Ala44Pro Uncertain significance Single submitter
- YBX3 p.Arg133Cys Uncertain significance Single submitter
- YBX3 p.Arg133Ser Uncertain significance Single submitter
- YBX3 p.Arg176His Uncertain significance Single submitter
- YBX3 p.Arg179Cys Uncertain significance Single submitter
- YBX3 p.Arg220Gln Uncertain significance Single submitter
- YBX3 p.Arg224His Uncertain significance Single submitter
- YBX3 p.Arg233Gln Uncertain significance Single submitter
- YBX3 p.Arg233Trp Uncertain significance Single submitter
- YBX3 p.Arg235Gln Uncertain significance Single submitter
- YBX3 p.Arg236Gln Uncertain significance Single submitter
- YBX3 p.Arg288His Uncertain significance Single submitter
- YBX3 p.Arg336Gln Uncertain significance Single submitter
- YBX3 p.Arg340His Uncertain significance Single submitter
- YBX3 p.Asp310Ala Uncertain significance Single submitter
- YBX3 p.Gln120Arg Uncertain significance Single submitter
- YBX3 p.Gln215Arg Uncertain significance Single submitter
- YBX3 p.Gln231His Uncertain significance Single submitter
- YBX3 p.Gln234Arg Uncertain significance Single submitter
- YBX3 p.Gln314His Uncertain significance Single submitter
- YBX3 p.Gln42Pro Uncertain significance Single submitter
- YBX3 p.Glu6Lys Uncertain significance Single submitter
- YBX3 p.Gly265Glu Uncertain significance Single submitter
- YBX3 p.Gly5Ala Uncertain significance Single submitter
- YBX3 p.Gly5Asp Uncertain significance Single submitter
- YBX3 p.His255Asn Uncertain significance Single submitter
- YBX3 p.His255Tyr Uncertain significance Single submitter
- YBX3 p.His282Arg Uncertain significance Single submitter
- YBX3 p.Ile107Val Uncertain significance Single submitter
- YBX3 p.Phe117Ser Uncertain significance Single submitter
- YBX3 p.Pro160Arg Uncertain significance Single submitter
- YBX3 p.Pro160Leu Uncertain significance Single submitter
- YBX3 p.Pro210Arg Uncertain significance Single submitter
- YBX3 p.Pro280Gln Uncertain significance Single submitter
- YBX3 p.Pro280Leu Uncertain significance Single submitter
- YBX3 p.Pro285Ala Uncertain significance Single submitter
- YBX3 p.Pro301Leu Uncertain significance Single submitter
- YBX3 p.Pro323Leu Uncertain significance Single submitter
- YBX3 p.Pro32Thr Uncertain significance Single submitter
- YBX3 p.Ser250Pro Uncertain significance Single submitter
- YBX3 p.Ser318Arg Uncertain significance Single submitter
- YBX3 p.Ser346Leu Uncertain significance Single submitter
- YBX3 p.Thr10Pro Uncertain significance Single submitter
- YBX3 p.Thr20Arg Uncertain significance Single submitter
- YBX3 p.Thr245Ile Uncertain significance Single submitter
- YBX3 p.Thr286Pro Uncertain significance Single submitter
- YBX3 p.Thr8Ala Uncertain significance Single submitter
- YBX3 p.Val281Gly Uncertain significance Single submitter
- YBX3 p.Val36Leu Uncertain significance Single submitter
Predictors split 20
The independent predictors disagree with each other — read with care.
- YBX3 p.Arg174Trp Uncertain significance Single submitter
- YBX3 p.Arg175Cys Uncertain significance Single submitter
- YBX3 p.Arg176Cys Uncertain significance Single submitter
- YBX3 p.Arg186Cys Uncertain significance Single submitter
- YBX3 p.Arg186Ser Uncertain significance Single submitter
- YBX3 p.Arg190Leu Uncertain significance Single submitter
- YBX3 p.Arg190Trp Uncertain significance Single submitter
- YBX3 p.Arg288Leu Uncertain significance Single submitter
- YBX3 p.Arg290Thr Uncertain significance Single submitter
- YBX3 p.Arg298Cys Uncertain significance Single submitter
- YBX3 p.Arg298Gly Uncertain significance Single submitter
- YBX3 p.Arg298His Uncertain significance Single submitter
- YBX3 p.Arg327Cys Uncertain significance Single submitter
- YBX3 p.Arg330Trp Uncertain significance Single submitter
- YBX3 p.Arg331His Uncertain significance Single submitter
- YBX3 p.Arg336Trp Uncertain significance Single submitter
- YBX3 p.Arg337His Uncertain significance Single submitter
- YBX3 p.Glu149Val Uncertain significance Single submitter
- YBX3 p.Gly180Asp Uncertain significance Single submitter
- YBX3 p.Tyr182Cys Uncertain significance Single submitter
All YBX3 variants
Likely benign 2
- p.Gln276= Single submitter
- p.Thr20Ala Single submitter
Uncertain significance 73
- p.Ala154Val Single submitter ⚠
- p.Ala193Thr Single submitter ⚠
- p.Ala219Ser Single submitter ⚠
- p.Ala44Pro Single submitter ⚠
- p.Arg133Cys Single submitter ⚠
- p.Arg133Ser Single submitter ⚠
- p.Arg174Trp Single submitter ⚠
- p.Arg175Cys Single submitter ⚠
- p.Arg176Cys Single submitter ⚠
- p.Arg176His Single submitter ⚠
- p.Arg179Cys Single submitter ⚠
- p.Arg186Cys Single submitter ⚠
- p.Arg186Ser Single submitter ⚠
- p.Arg190Leu Single submitter ⚠
- p.Arg190Trp Single submitter ⚠
- p.Arg220Gln Single submitter ⚠
- p.Arg224His Single submitter ⚠
- p.Arg233Gln Single submitter ⚠
- p.Arg233Trp Single submitter ⚠
- p.Arg235Gln Single submitter ⚠
- p.Arg236Gln Single submitter ⚠
- p.Arg288His Single submitter ⚠
- p.Arg288Leu Single submitter ⚠
- p.Arg290Thr Single submitter ⚠
- p.Arg298Cys Single submitter ⚠
- p.Arg298Gly Single submitter ⚠
- p.Arg298His Single submitter ⚠
- p.Arg327Cys Single submitter ⚠
- p.Arg330Trp Single submitter ⚠
- p.Arg331His Single submitter ⚠
- p.Arg336Gln Single submitter ⚠
- p.Arg336Trp Single submitter ⚠
- p.Arg337Cys Single submitter
- p.Arg337His Single submitter ⚠
- p.Arg340His Single submitter ⚠
- p.Asp310Ala Single submitter ⚠
- p.Gln120Arg Single submitter ⚠
- p.Gln215Arg Single submitter ⚠
- p.Gln231His Single submitter ⚠
- p.Gln234Arg Single submitter ⚠
- p.Gln314His Single submitter ⚠
- p.Gln42Pro Single submitter ⚠
- p.Glu149Val Single submitter ⚠
- p.Glu6Lys Single submitter ⚠
- p.Gly180Asp Single submitter ⚠
- p.Gly265Glu Single submitter ⚠
- p.Gly5Ala Single submitter ⚠
- p.Gly5Asp Single submitter ⚠
- p.His255Asn Single submitter ⚠
- p.His255Tyr Single submitter ⚠
- p.His282Arg Single submitter ⚠
- p.Ile107Val Single submitter ⚠
- p.Phe117Ser Single submitter ⚠
- p.Pro160Arg Single submitter ⚠
- p.Pro160Leu Single submitter ⚠
- p.Pro210Arg Single submitter ⚠
- p.Pro280Gln Single submitter ⚠
- p.Pro280Leu Single submitter ⚠
- p.Pro285Ala Single submitter ⚠
- p.Pro301Leu Single submitter ⚠
- p.Pro323Leu Single submitter ⚠
- p.Pro32Thr Single submitter ⚠
- p.Ser250Pro Single submitter ⚠
- p.Ser318Arg Single submitter ⚠
- p.Ser346Leu Single submitter ⚠
- p.Thr10Pro Single submitter ⚠
- p.Thr20Arg Single submitter ⚠
- p.Thr245Ile Single submitter ⚠
- p.Thr286Pro Single submitter ⚠
- p.Thr8Ala Single submitter ⚠
- p.Tyr182Cys Single submitter ⚠
- p.Val281Gly Single submitter ⚠
- p.Val36Leu Single submitter ⚠