YES1 — 60 ClinVar variants
All ClinVar germline YES1 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 55 flagged for review →
2 Likely benign · 58 Uncertain significance
Full YES1 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 55
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 44
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- YES1 p.Ala413Thr Uncertain significance Single submitter
- YES1 p.Ala443Ser Uncertain significance Single submitter
- YES1 p.Ala87Gly Uncertain significance Single submitter
- YES1 p.Arg199Cys Uncertain significance Single submitter
- YES1 p.Arg274Gln Uncertain significance Single submitter
- YES1 p.Asn219Ser Uncertain significance Single submitter
- YES1 p.Asn401Asp Uncertain significance Single submitter
- YES1 p.Asn424Asp Uncertain significance Single submitter
- YES1 p.Asn424Ser Uncertain significance Single submitter
- YES1 p.Asp364Glu Uncertain significance Single submitter
- YES1 p.Asp514Glu Uncertain significance Single submitter
- YES1 p.Gln430Arg Uncertain significance Single submitter
- YES1 p.Glu541Asp Uncertain significance Single submitter
- YES1 p.Gly363Arg Uncertain significance Single submitter
- YES1 p.Gly67Arg Uncertain significance Single submitter
- YES1 p.Ile134Val Uncertain significance Single submitter
- YES1 p.Ile214Val Uncertain significance Single submitter
- YES1 p.Ile304Val Uncertain significance Single submitter
- YES1 p.Ile387Thr Uncertain significance Single submitter
- YES1 p.Ile95Val Uncertain significance Single submitter
- YES1 p.Lys138Asn Uncertain significance Single submitter
- YES1 p.Lys301Glu Uncertain significance Single submitter
- YES1 p.Lys411Arg Uncertain significance Single submitter
- YES1 p.Met324Arg Uncertain significance Single submitter
- YES1 p.Met376Arg Uncertain significance Single submitter
- YES1 p.Met476Val Uncertain significance Single submitter
- YES1 p.Phe118Cys Uncertain significance Single submitter
- YES1 p.Phe78Leu Uncertain significance Single submitter
- YES1 p.Pro12Ser Uncertain significance Single submitter
- YES1 p.Pro343Arg Uncertain significance Single submitter
- YES1 p.Pro36Leu Uncertain significance Single submitter
- YES1 p.Ser66Leu Uncertain significance Single submitter
- YES1 p.Thr241Ala Uncertain significance Single submitter
- YES1 p.Thr241Arg Uncertain significance Single submitter
- YES1 p.Thr253Ala Uncertain significance Single submitter
- YES1 p.Thr450Ile Uncertain significance Single submitter
- YES1 p.Thr518Ile Uncertain significance Single submitter
- YES1 p.Trp158Cys Uncertain significance Single submitter
- YES1 p.Tyr194Phe Uncertain significance Single submitter
- YES1 p.Tyr32Cys Uncertain significance Single submitter
- YES1 p.Tyr336Phe Uncertain significance Single submitter
- YES1 p.Tyr367His Uncertain significance Single submitter
- YES1 p.Val471Gly Uncertain significance Single submitter
- YES1 p.Val81Met Uncertain significance Single submitter
Predictors split 11
The independent predictors disagree with each other — read with care.
- YES1 p.Ala148Val Uncertain significance Single submitter
- YES1 p.Ala244Val Uncertain significance Single submitter
- YES1 p.Ala532Gly Uncertain significance Single submitter
- YES1 p.Gln229Arg Uncertain significance Single submitter
- YES1 p.Glu520Gly Uncertain significance Single submitter
- YES1 p.Phe160Val Uncertain significance Single submitter
- YES1 p.Pro175Leu Uncertain significance Single submitter
- YES1 p.Ser355Asn Uncertain significance Single submitter
- YES1 p.Ser58Cys Uncertain significance Single submitter
- YES1 p.Thr300Met Uncertain significance Single submitter
- YES1 p.Tyr336His Uncertain significance Single submitter
All YES1 variants
Likely benign 2
- p.Ala87Thr Single submitter
- p.Lys113Gln Single submitter
Uncertain significance 58
- c.371+1G>T Single submitter
- p.Ala148Val Single submitter ⚠
- p.Ala244Val Single submitter ⚠
- p.Ala413Thr Single submitter ⚠
- p.Ala443Ser Single submitter ⚠
- p.Ala532Gly Single submitter ⚠
- p.Ala87Gly Single submitter ⚠
- p.Arg199Cys Single submitter ⚠
- p.Arg274Gln Single submitter ⚠
- p.Arg448Gln Single submitter
- p.Asn219Ser Single submitter ⚠
- p.Asn401Asp Single submitter ⚠
- p.Asn424Asp Single submitter ⚠
- p.Asn424Ser Single submitter ⚠
- p.Asp364Glu Single submitter ⚠
- p.Asp514Glu Single submitter ⚠
- p.Gln229Arg Single submitter ⚠
- p.Gln234Arg Single submitter
- p.Gln430Arg Single submitter ⚠
- p.Glu520Gly Single submitter ⚠
- p.Glu541Asp Single submitter ⚠
- p.Gly363Arg Single submitter ⚠
- p.Gly67Arg Single submitter ⚠
- p.Ile134Val Single submitter ⚠
- p.Ile214Val Single submitter ⚠
- p.Ile304Val Single submitter ⚠
- p.Ile387Thr Single submitter ⚠
- p.Ile95Val Single submitter ⚠
- p.Lys138Asn Single submitter ⚠
- p.Lys301Glu Single submitter ⚠
- p.Lys411Arg Single submitter ⚠
- p.Met324Arg Single submitter ⚠
- p.Met376Arg Single submitter ⚠
- p.Met476Val Single submitter ⚠
- p.Phe118Cys Single submitter ⚠
- p.Phe160Val Single submitter ⚠
- p.Phe78Leu Single submitter ⚠
- p.Pro12Ser Single submitter ⚠
- p.Pro175Leu Single submitter ⚠
- p.Pro343Arg Single submitter ⚠
- p.Pro36Leu Single submitter ⚠
- p.Ser355Asn Single submitter ⚠
- p.Ser58Cys Single submitter ⚠
- p.Ser66Leu Single submitter ⚠
- p.Thr241Ala Single submitter ⚠
- p.Thr241Arg Single submitter ⚠
- p.Thr253Ala Single submitter ⚠
- p.Thr300Met Single submitter ⚠
- p.Thr450Ile Single submitter ⚠
- p.Thr518Ile Single submitter ⚠
- p.Trp158Cys Single submitter ⚠
- p.Tyr194Phe Single submitter ⚠
- p.Tyr32Cys Single submitter ⚠
- p.Tyr336His Single submitter ⚠
- p.Tyr336Phe Single submitter ⚠
- p.Tyr367His Single submitter ⚠
- p.Val471Gly Single submitter ⚠
- p.Val81Met Single submitter ⚠