YIF1A — 60 ClinVar variants
All ClinVar germline YIF1A variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 53 flagged for review →
3 Likely benign · 57 Uncertain significance
Full YIF1A gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 53
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 45
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- YIF1A p.Ala103Thr Uncertain significance Single submitter
- YIF1A p.Ala16Val Uncertain significance Single submitter
- YIF1A p.Ala233Val Uncertain significance Single submitter
- YIF1A p.Ala63Thr Uncertain significance Single submitter
- YIF1A p.Ala65Gly Uncertain significance Single submitter
- YIF1A p.Ala65Ser Uncertain significance Single submitter
- YIF1A p.Arg124Leu Uncertain significance Single submitter
- YIF1A p.Arg131Gln Uncertain significance Single submitter
- YIF1A p.Arg131Pro Uncertain significance Single submitter
- YIF1A p.Arg196Cys Uncertain significance Single submitter
- YIF1A p.Arg265Gln Uncertain significance Single submitter
- YIF1A p.Arg267His Uncertain significance Single submitter
- YIF1A p.Arg293Gln Uncertain significance Single submitter
- YIF1A p.Asn117Thr Uncertain significance Single submitter
- YIF1A p.Asp228Asn Uncertain significance Single submitter
- YIF1A p.Asp257Asn Uncertain significance Single submitter
- YIF1A p.Gln116Leu Uncertain significance Single submitter
- YIF1A p.Gly67Ser Uncertain significance Single submitter
- YIF1A p.Ile159Val Uncertain significance Single submitter
- YIF1A p.Leu134Pro Uncertain significance Single submitter
- YIF1A p.Leu249Trp Uncertain significance Single submitter
- YIF1A p.Leu54Val Uncertain significance Single submitter
- YIF1A p.Lys211Arg Uncertain significance Single submitter
- YIF1A p.Lys211Ile Uncertain significance Single submitter
- YIF1A p.Lys80Arg Uncertain significance Single submitter
- YIF1A p.Met181Ile Uncertain significance Single submitter
- YIF1A p.Met259Ile Uncertain significance Single submitter
- YIF1A p.Met77Val Uncertain significance Single submitter
- YIF1A p.Pro165Leu Uncertain significance Single submitter
- YIF1A p.Pro264Leu Uncertain significance Single submitter
- YIF1A p.Pro37His Uncertain significance Single submitter
- YIF1A p.Ser123Arg Uncertain significance Single submitter
- YIF1A p.Ser258Gly Uncertain significance Single submitter
- YIF1A p.Ser35Gly Uncertain significance Single submitter
- YIF1A p.Ser50Ile Uncertain significance Single submitter
- YIF1A p.Thr114Ala Uncertain significance Single submitter
- YIF1A p.Thr143Met Uncertain significance Single submitter
- YIF1A p.Tyr140Cys Uncertain significance Single submitter
- YIF1A p.Tyr66Cys Uncertain significance Single submitter
- YIF1A p.Val102Met Uncertain significance Single submitter
- YIF1A p.Val120Met Uncertain significance Single submitter
- YIF1A p.Val213Met Uncertain significance Single submitter
- YIF1A p.Val219Met Uncertain significance Single submitter
- YIF1A p.Val263Ile Uncertain significance Single submitter
- YIF1A p.Val263Leu Uncertain significance Single submitter
Predictors split 8
The independent predictors disagree with each other — read with care.
- YIF1A p.Arg17Trp Uncertain significance Single submitter
- YIF1A p.Arg247His Uncertain significance Single submitter
- YIF1A p.Arg265Trp Uncertain significance Single submitter
- YIF1A p.Arg267Cys Uncertain significance Single submitter
- YIF1A p.Ile283Thr Uncertain significance Single submitter
- YIF1A p.Leu139Phe Uncertain significance Single submitter
- YIF1A p.Phe94Ile Uncertain significance Single submitter
- YIF1A p.Tyr231Cys Uncertain significance Single submitter
All YIF1A variants
Likely benign 3
- p.Met59Val Single submitter
- p.Thr194= Single submitter
- p.Tyr149= Single submitter
Uncertain significance 57
- p.Ala103Thr Single submitter ⚠
- p.Ala16Val Single submitter ⚠
- p.Ala233Val Single submitter ⚠
- p.Ala63Thr Single submitter ⚠
- p.Ala65Gly Single submitter ⚠
- p.Ala65Ser Single submitter ⚠
- p.Arg124Leu Single submitter ⚠
- p.Arg131Gln Single submitter ⚠
- p.Arg131Pro Single submitter ⚠
- p.Arg17Trp Single submitter ⚠
- p.Arg196Cys Single submitter ⚠
- p.Arg247His Single submitter ⚠
- p.Arg265Gln Single submitter ⚠
- p.Arg265Trp Single submitter ⚠
- p.Arg267Cys Single submitter ⚠
- p.Arg267His Single submitter ⚠
- p.Arg293Gln Single submitter ⚠
- p.Arg84Cys Single submitter
- p.Arg84Gly Single submitter
- p.Asn117Thr Single submitter ⚠
- p.Asp228Asn Single submitter ⚠
- p.Asp257Asn Single submitter ⚠
- p.Gln116Leu Single submitter ⚠
- p.Gly67Ser Single submitter ⚠
- p.His115Tyr Single submitter
- p.Ile159Val Single submitter ⚠
- p.Ile283Thr Single submitter ⚠
- p.Leu134Pro Single submitter ⚠
- p.Leu139Phe Single submitter ⚠
- p.Leu249Trp Single submitter ⚠
- p.Leu54Val Single submitter ⚠
- p.Lys211Arg Single submitter ⚠
- p.Lys211Ile Single submitter ⚠
- p.Lys80Arg Single submitter ⚠
- p.Met181Ile Single submitter ⚠
- p.Met259Ile Single submitter ⚠
- p.Met77Val Single submitter ⚠
- p.Phe94Ile Single submitter ⚠
- p.Pro165Leu Single submitter ⚠
- p.Pro264Leu Single submitter ⚠
- p.Pro37His Single submitter ⚠
- p.Ser123Arg Single submitter ⚠
- p.Ser258Gly Single submitter ⚠
- p.Ser35Gly Single submitter ⚠
- p.Ser50Ile Single submitter ⚠
- p.Thr114Ala Single submitter ⚠
- p.Thr143Met Single submitter ⚠
- p.Tyr140Cys Single submitter ⚠
- p.Tyr231Cys Single submitter ⚠
- p.Tyr66Cys Single submitter ⚠
- p.Val102Met Single submitter ⚠
- p.Val120Met Single submitter ⚠
- p.Val150Met Single submitter
- p.Val213Met Single submitter ⚠
- p.Val219Met Single submitter ⚠
- p.Val263Ile Single submitter ⚠
- p.Val263Leu Single submitter ⚠