YTHDF2 — 47 ClinVar variants
All ClinVar germline YTHDF2 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 45 flagged for review →
1 Likely benign · 46 Uncertain significance
Full YTHDF2 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 45
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 36
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- YTHDF2 p.Ala170Gly Uncertain significance Single submitter
- YTHDF2 p.Ala285Gly Uncertain significance Single submitter
- YTHDF2 p.Arg10Lys Uncertain significance Single submitter
- YTHDF2 p.Arg574His Uncertain significance Single submitter
- YTHDF2 p.Asp496Asn Uncertain significance Single submitter
- YTHDF2 p.Gln327Arg Uncertain significance Single submitter
- YTHDF2 p.Gly377Arg Uncertain significance Single submitter
- YTHDF2 p.His24Tyr Uncertain significance Single submitter
- YTHDF2 p.His363Arg Uncertain significance Single submitter
- YTHDF2 p.His466Arg Uncertain significance Single submitter
- YTHDF2 p.Ile129Thr Uncertain significance Single submitter
- YTHDF2 p.Ile185Val Uncertain significance Single submitter
- YTHDF2 p.Ile415Thr Uncertain significance Single submitter
- YTHDF2 p.Lys548Arg Uncertain significance Single submitter
- YTHDF2 p.Met104Leu Uncertain significance Single submitter
- YTHDF2 p.Met51Val Uncertain significance Single submitter
- YTHDF2 p.Met83Val Uncertain significance Single submitter
- YTHDF2 p.Pro180Ala Uncertain significance Single submitter
- YTHDF2 p.Pro236Ser Uncertain significance Single submitter
- YTHDF2 p.Pro304Thr Uncertain significance Single submitter
- YTHDF2 p.Pro316Leu Uncertain significance Single submitter
- YTHDF2 p.Pro331Leu Uncertain significance Single submitter
- YTHDF2 p.Pro354Leu Uncertain significance Single submitter
- YTHDF2 p.Pro36Thr Uncertain significance Single submitter
- YTHDF2 p.Ser147Pro Uncertain significance Single submitter
- YTHDF2 p.Ser196Asn Uncertain significance Single submitter
- YTHDF2 p.Ser201Asn Uncertain significance Single submitter
- YTHDF2 p.Ser201Gly Uncertain significance Single submitter
- YTHDF2 p.Ser39Asn Uncertain significance Single submitter
- YTHDF2 p.Ser546Thr Uncertain significance Single submitter
- YTHDF2 p.Ser558Thr Uncertain significance Single submitter
- YTHDF2 p.Thr197Ala Uncertain significance Single submitter
- YTHDF2 p.Thr217Ala Uncertain significance Single submitter
- YTHDF2 p.Tyr547Cys Uncertain significance Single submitter
- YTHDF2 p.Tyr85Phe Uncertain significance Single submitter
- YTHDF2 p.Val455Ile Uncertain significance Single submitter
Predictors split 9
The independent predictors disagree with each other — read with care.
- YTHDF2 p.Arg393Trp Uncertain significance Single submitter
- YTHDF2 p.Glu8Gln Uncertain significance Single submitter
- YTHDF2 p.Gly212Arg Uncertain significance Single submitter
- YTHDF2 p.Gly451Arg Uncertain significance Single submitter
- YTHDF2 p.Leu70Ser Uncertain significance Single submitter
- YTHDF2 p.Ser143Cys Uncertain significance Single submitter
- YTHDF2 p.Ser146Arg Uncertain significance Single submitter
- YTHDF2 p.Ser569Arg Uncertain significance Single submitter
- YTHDF2 p.Ser76Phe Uncertain significance Single submitter
All YTHDF2 variants
Likely benign 1
- p.Asn173Ser Single submitter
Uncertain significance 46
- p.Ala170Gly Single submitter ⚠
- p.Ala285Gly Single submitter ⚠
- p.Arg10Lys Single submitter ⚠
- p.Arg393Trp Single submitter ⚠
- p.Arg574His Single submitter ⚠
- p.Asp496Asn Single submitter ⚠
- p.Gln327Arg Single submitter ⚠
- p.Glu8Gln Single submitter ⚠
- p.Gly212Arg Single submitter ⚠
- p.Gly377Arg Single submitter ⚠
- p.Gly451Arg Single submitter ⚠
- p.Gly79_Asp80insTer Single submitter
- p.His24Tyr Single submitter ⚠
- p.His363Arg Single submitter ⚠
- p.His466Arg Single submitter ⚠
- p.Ile129Thr Single submitter ⚠
- p.Ile185Val Single submitter ⚠
- p.Ile415Thr Single submitter ⚠
- p.Leu70Ser Single submitter ⚠
- p.Lys548Arg Single submitter ⚠
- p.Met104Leu Single submitter ⚠
- p.Met51Val Single submitter ⚠
- p.Met83Val Single submitter ⚠
- p.Pro180Ala Single submitter ⚠
- p.Pro236Ser Single submitter ⚠
- p.Pro304Thr Single submitter ⚠
- p.Pro316Leu Single submitter ⚠
- p.Pro331Leu Single submitter ⚠
- p.Pro354Leu Single submitter ⚠
- p.Pro36Thr Single submitter ⚠
- p.Ser143Cys Single submitter ⚠
- p.Ser146Arg Single submitter ⚠
- p.Ser147Pro Single submitter ⚠
- p.Ser196Asn Single submitter ⚠
- p.Ser201Asn Single submitter ⚠
- p.Ser201Gly Single submitter ⚠
- p.Ser39Asn Single submitter ⚠
- p.Ser546Thr Single submitter ⚠
- p.Ser558Thr Single submitter ⚠
- p.Ser569Arg Single submitter ⚠
- p.Ser76Phe Single submitter ⚠
- p.Thr197Ala Single submitter ⚠
- p.Thr217Ala Single submitter ⚠
- p.Tyr547Cys Single submitter ⚠
- p.Tyr85Phe Single submitter ⚠
- p.Val455Ile Single submitter ⚠