YWHAQ — 18 ClinVar variants
All ClinVar germline YWHAQ variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 16 flagged for review →
18 Uncertain significance
Full YWHAQ gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 16
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 12
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- YWHAQ p.Ala10Gly Uncertain significance Single submitter
- YWHAQ p.Ala171Thr Uncertain significance Single submitter
- YWHAQ p.Arg167Cys Uncertain significance Single submitter
- YWHAQ p.Arg167His Uncertain significance Single submitter
- YWHAQ p.Arg83Pro Uncertain significance Single submitter
- YWHAQ p.Asn108Ser Uncertain significance Single submitter
- YWHAQ p.Cys25Tyr Uncertain significance Single submitter
- YWHAQ p.Gln77Glu Uncertain significance Single submitter
- YWHAQ p.Ile155Thr Uncertain significance Single submitter
- YWHAQ p.Lys68Asn Uncertain significance Single submitter
- YWHAQ p.Lys68Thr Uncertain significance Single submitter
- YWHAQ p.Ser232Thr Uncertain significance Single submitter
Predictors split 4
The independent predictors disagree with each other — read with care.
All YWHAQ variants
Uncertain significance 18
- p.Ala10Gly Single submitter ⚠
- p.Ala171Thr Single submitter ⚠
- p.Arg167Cys Single submitter ⚠
- p.Arg167His Single submitter ⚠
- p.Arg83Pro Single submitter ⚠
- p.Asn108Ser Single submitter ⚠
- p.Cys25Tyr Single submitter ⚠
- p.Gln77Arg Single submitter ⚠
- p.Gln77Glu Single submitter ⚠
- p.Glu5Gln Single submitter ⚠
- p.Ile155Thr Single submitter ⚠
- p.Ile166Val Single submitter
- p.Lys68Asn Single submitter ⚠
- p.Lys68Thr Single submitter ⚠
- p.Ser232Thr Single submitter ⚠
- p.Ser64Gly Single submitter
- p.Ser92Phe Single submitter ⚠
- p.Ser92Tyr Single submitter ⚠