ZBED2 — 42 ClinVar variants
All ClinVar germline ZBED2 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 40 flagged for review →
1 Likely benign · 41 Uncertain significance
Full ZBED2 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 40
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 34
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- ZBED2 p.Ala118Asp Uncertain significance Single submitter
- ZBED2 p.Ala197Val Uncertain significance Single submitter
- ZBED2 p.Ala211Val Uncertain significance Single submitter
- ZBED2 p.Ala41Val Uncertain significance Single submitter
- ZBED2 p.Ala57Val Uncertain significance Single submitter
- ZBED2 p.Arg121Cys Uncertain significance Single submitter
- ZBED2 p.Arg121Gly Uncertain significance Single submitter
- ZBED2 p.Arg121His Uncertain significance Single submitter
- ZBED2 p.Arg141Ser Uncertain significance Single submitter
- ZBED2 p.Arg162Lys Uncertain significance Single submitter
- ZBED2 p.Arg179Gln Uncertain significance Single submitter
- ZBED2 p.Arg4Gln Uncertain significance Single submitter
- ZBED2 p.Arg53Trp Uncertain significance Single submitter
- ZBED2 p.Arg67Cys Uncertain significance Single submitter
- ZBED2 p.Arg79His Uncertain significance Single submitter
- ZBED2 p.Asn138Tyr Uncertain significance Single submitter
- ZBED2 p.Glu21Asp Uncertain significance Single submitter
- ZBED2 p.Glu24Lys Uncertain significance Single submitter
- ZBED2 p.Glu25Lys Uncertain significance Single submitter
- ZBED2 p.Gly128Arg Uncertain significance Single submitter
- ZBED2 p.Gly137Ser Uncertain significance Single submitter
- ZBED2 p.Gly147Asp Uncertain significance Single submitter
- ZBED2 p.Gly32Arg Uncertain significance Single submitter
- ZBED2 p.His70Arg Uncertain significance Single submitter
- ZBED2 p.Leu161Ile Uncertain significance Single submitter
- ZBED2 p.Met14Lys Uncertain significance Single submitter
- ZBED2 p.Met14Thr Uncertain significance Single submitter
- ZBED2 p.Met42Leu Uncertain significance Single submitter
- ZBED2 p.Met42Val Uncertain significance Single submitter
- ZBED2 p.Pro37Arg Uncertain significance Single submitter
- ZBED2 p.Pro43Leu Uncertain significance Single submitter
- ZBED2 p.Thr44Pro Uncertain significance Single submitter
- ZBED2 p.Val35Ala Uncertain significance Single submitter
- ZBED2 p.Val91Ala Uncertain significance Single submitter
Predictors split 6
The independent predictors disagree with each other — read with care.
- ZBED2 p.Arg170Gln Uncertain significance Single submitter
- ZBED2 p.Arg170Leu Uncertain significance Single submitter
- ZBED2 p.Arg170Pro Uncertain significance Single submitter
- ZBED2 p.Asn92Thr Uncertain significance Single submitter
- ZBED2 p.Glu171Asp Uncertain significance Single submitter
- ZBED2 p.His62Arg Uncertain significance Single submitter
All ZBED2 variants
Likely benign 1
- p.Glu7Lys Single submitter
Uncertain significance 41
- p.Ala118Asp Single submitter ⚠
- p.Ala197Val Single submitter ⚠
- p.Ala211Val Single submitter ⚠
- p.Ala41Val Single submitter ⚠
- p.Ala57Val Single submitter ⚠
- p.Arg121Cys Single submitter ⚠
- p.Arg121Gly Single submitter ⚠
- p.Arg121His Single submitter ⚠
- p.Arg141Ser Single submitter ⚠
- p.Arg162Lys Single submitter ⚠
- p.Arg170Gln Single submitter ⚠
- p.Arg170Leu Single submitter ⚠
- p.Arg170Pro Single submitter ⚠
- p.Arg179Gln Single submitter ⚠
- p.Arg4Gln Single submitter ⚠
- p.Arg53Trp Single submitter ⚠
- p.Arg67Cys Single submitter ⚠
- p.Arg79His Single submitter ⚠
- p.Asn138Tyr Single submitter ⚠
- p.Asn92Thr Single submitter ⚠
- p.Glu171Asp Single submitter ⚠
- p.Glu21Asp Single submitter ⚠
- p.Glu24Lys Single submitter ⚠
- p.Glu25Lys Single submitter ⚠
- p.Gly128Arg Single submitter ⚠
- p.Gly137Ser Single submitter ⚠
- p.Gly147Asp Single submitter ⚠
- p.Gly32Arg Single submitter ⚠
- p.His62Arg Single submitter ⚠
- p.His70Arg Single submitter ⚠
- p.Leu161Ile Single submitter ⚠
- p.Met14Lys Single submitter ⚠
- p.Met14Thr Single submitter ⚠
- p.Met42Leu Single submitter ⚠
- p.Met42Val Single submitter ⚠
- p.Pro37Arg Single submitter ⚠
- p.Pro43Leu Single submitter ⚠
- p.Pro65Arg Single submitter
- p.Thr44Pro Single submitter ⚠
- p.Val35Ala Single submitter ⚠
- p.Val91Ala Single submitter ⚠