ZDHHC2 — 46 ClinVar variants
All ClinVar germline ZDHHC2 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 44 flagged for review →
1 Likely benign · 45 Uncertain significance
Full ZDHHC2 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 44
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 35
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- ZDHHC2 p.Ala125Gly Uncertain significance Single submitter
- ZDHHC2 p.Ala305Thr Uncertain significance Single submitter
- ZDHHC2 p.Ala315Asp Uncertain significance Single submitter
- ZDHHC2 p.Arg110Gln Uncertain significance Single submitter
- ZDHHC2 p.Arg127Gln Uncertain significance Single submitter
- ZDHHC2 p.Asn162Ser Uncertain significance Single submitter
- ZDHHC2 p.Asp93Gly Uncertain significance Single submitter
- ZDHHC2 p.Cys291Tyr Uncertain significance Single submitter
- ZDHHC2 p.Glu51Gln Uncertain significance Single submitter
- ZDHHC2 p.Glu51Lys Uncertain significance Single submitter
- ZDHHC2 p.Gly259Glu Uncertain significance Single submitter
- ZDHHC2 p.His253Gln Uncertain significance Single submitter
- ZDHHC2 p.Ile74Val Uncertain significance Single submitter
- ZDHHC2 p.Leu311Gln Uncertain significance Single submitter
- ZDHHC2 p.Leu311Pro Uncertain significance Single submitter
- ZDHHC2 p.Leu311Val Uncertain significance Single submitter
- ZDHHC2 p.Leu318Arg Uncertain significance Single submitter
- ZDHHC2 p.Met153Val Uncertain significance Single submitter
- ZDHHC2 p.Met363Thr Uncertain significance Single submitter
- ZDHHC2 p.Met79Val Uncertain significance Single submitter
- ZDHHC2 p.Phe194Cys Uncertain significance Single submitter
- ZDHHC2 p.Phe209Val Uncertain significance Single submitter
- ZDHHC2 p.Ser241Pro Uncertain significance Single submitter
- ZDHHC2 p.Ser248Thr Uncertain significance Single submitter
- ZDHHC2 p.Ser306Cys Uncertain significance Single submitter
- ZDHHC2 p.Thr343Ala Uncertain significance Single submitter
- ZDHHC2 p.Thr343Met Uncertain significance Single submitter
- ZDHHC2 p.Thr367Ile Uncertain significance Single submitter
- ZDHHC2 p.Thr49Ser Uncertain significance Single submitter
- ZDHHC2 p.Tyr178Asn Uncertain significance Single submitter
- ZDHHC2 p.Tyr59Cys Uncertain significance Single submitter
- ZDHHC2 p.Val107Ile Uncertain significance Single submitter
- ZDHHC2 p.Val250Ile Uncertain significance Single submitter
- ZDHHC2 p.Val53Ala Uncertain significance Single submitter
- ZDHHC2 p.Val54Met Uncertain significance Single submitter
Predictors split 9
The independent predictors disagree with each other — read with care.
- ZDHHC2 p.Arg131Ile Uncertain significance Single submitter
- ZDHHC2 p.Arg131Ser Uncertain significance Single submitter
- ZDHHC2 p.Asp114Val Uncertain significance Single submitter
- ZDHHC2 p.Asp204Gly Uncertain significance Single submitter
- ZDHHC2 p.Gln105Arg Uncertain significance Single submitter
- ZDHHC2 p.Lys277Thr Uncertain significance Single submitter
- ZDHHC2 p.Met220Leu Uncertain significance Single submitter
- ZDHHC2 p.Phe63Cys Uncertain significance Single submitter
- ZDHHC2 p.Ser123Cys Uncertain significance Single submitter
All ZDHHC2 variants
Likely benign 1
- p.Lys148= Single submitter
Uncertain significance 45
- p.Ala125Gly Single submitter ⚠
- p.Ala305Thr Single submitter ⚠
- p.Ala315Asp Single submitter ⚠
- p.Arg110Gln Single submitter ⚠
- p.Arg127Gln Single submitter ⚠
- p.Arg131Ile Single submitter ⚠
- p.Arg131Ser Single submitter ⚠
- p.Asn162Ser Single submitter ⚠
- p.Asp114Val Single submitter ⚠
- p.Asp204Gly Single submitter ⚠
- p.Asp93Gly Single submitter ⚠
- p.Cys291Tyr Single submitter ⚠
- p.Gln105Arg Single submitter ⚠
- p.Glu51Gln Single submitter ⚠
- p.Glu51Lys Single submitter ⚠
- p.Gly259Glu Single submitter ⚠
- p.His253Gln Single submitter ⚠
- p.Ile74Val Single submitter ⚠
- p.Leu311Gln Single submitter ⚠
- p.Leu311Pro Single submitter ⚠
- p.Leu311Val Single submitter ⚠
- p.Leu318Arg Single submitter ⚠
- p.Lys277Thr Single submitter ⚠
- p.Met153Val Single submitter ⚠
- p.Met220Leu Single submitter ⚠
- p.Met363Thr Single submitter ⚠
- p.Met79Val Single submitter ⚠
- p.Phe194Cys Single submitter ⚠
- p.Phe209Val Single submitter ⚠
- p.Phe229fs Single submitter
- p.Phe63Cys Single submitter ⚠
- p.Ser123Cys Single submitter ⚠
- p.Ser241Pro Single submitter ⚠
- p.Ser248Thr Single submitter ⚠
- p.Ser306Cys Single submitter ⚠
- p.Thr343Ala Single submitter ⚠
- p.Thr343Met Single submitter ⚠
- p.Thr367Ile Single submitter ⚠
- p.Thr49Ser Single submitter ⚠
- p.Tyr178Asn Single submitter ⚠
- p.Tyr59Cys Single submitter ⚠
- p.Val107Ile Single submitter ⚠
- p.Val250Ile Single submitter ⚠
- p.Val53Ala Single submitter ⚠
- p.Val54Met Single submitter ⚠