ZDHHC20 — 50 ClinVar variants
All ClinVar germline ZDHHC20 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 42 flagged for review →
5 Likely benign · 45 Uncertain significance
Full ZDHHC20 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 42
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 29
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- ZDHHC20 p.Ala139Glu Uncertain significance Single submitter
- ZDHHC20 p.Ala144Thr Uncertain significance Single submitter
- ZDHHC20 p.Ala78Gly Uncertain significance Single submitter
- ZDHHC20 p.Ala78Ser Uncertain significance Single submitter
- ZDHHC20 p.Arg268Lys Uncertain significance Single submitter
- ZDHHC20 p.Arg333Cys Uncertain significance Single submitter
- ZDHHC20 p.Arg93His Uncertain significance Single submitter
- ZDHHC20 p.Asn161Ser Uncertain significance Single submitter
- ZDHHC20 p.Asn344Ser Uncertain significance Single submitter
- ZDHHC20 p.Asp203Asn Uncertain significance Single submitter
- ZDHHC20 p.Gly289Val Uncertain significance Single submitter
- ZDHHC20 p.Gly317Arg Uncertain significance Single submitter
- ZDHHC20 p.Ile116Val Uncertain significance Single submitter
- ZDHHC20 p.Ile282Met Uncertain significance Single submitter
- ZDHHC20 p.Leu176Ser Uncertain significance Single submitter
- ZDHHC20 p.Met299Arg Uncertain significance Single submitter
- ZDHHC20 p.Phe212Leu Uncertain significance Single submitter
- ZDHHC20 p.Phe98Ser Uncertain significance Single submitter
- ZDHHC20 p.Pro281Leu Uncertain significance Single submitter
- ZDHHC20 p.Pro321Arg Uncertain significance Single submitter
- ZDHHC20 p.Thr198Lys Uncertain significance Single submitter
- ZDHHC20 p.Thr198Met Uncertain significance Single submitter
- ZDHHC20 p.Thr249Met Uncertain significance Single submitter
- ZDHHC20 p.Thr5Arg Uncertain significance Single submitter
- ZDHHC20 p.Trp28Cys Uncertain significance Single submitter
- ZDHHC20 p.Tyr127His Uncertain significance Single submitter
- ZDHHC20 p.Tyr168His Uncertain significance Single submitter
- ZDHHC20 p.Val210Ile Uncertain significance Single submitter
- ZDHHC20 p.Val34Met Uncertain significance Single submitter
Predictors split 13
The independent predictors disagree with each other — read with care.
- ZDHHC20 p.Ala111Gly Uncertain significance Single submitter
- ZDHHC20 p.Ala247Thr Uncertain significance Single submitter
- ZDHHC20 p.Ala32Ser Uncertain significance Single submitter
- ZDHHC20 p.Arg246Cys Uncertain significance Single submitter
- ZDHHC20 p.Arg246His Uncertain significance Single submitter
- ZDHHC20 p.Arg295His Uncertain significance Single submitter
- ZDHHC20 p.Glu191Ala Uncertain significance Single submitter
- ZDHHC20 p.Leu190Val Uncertain significance Single submitter
- ZDHHC20 p.Met219Val Uncertain significance Single submitter
- ZDHHC20 p.Phe221Leu Uncertain significance Single submitter
- ZDHHC20 p.Thr294Ala Uncertain significance Single submitter
- ZDHHC20 p.Val185Leu Uncertain significance Single submitter
- ZDHHC20 p.Val185Met Uncertain significance Single submitter
All ZDHHC20 variants
Likely benign 5
- p.Ile282Val Single submitter
- p.Lys130Arg Single submitter
- p.Lys352Arg Single submitter
- p.Thr202Ser Single submitter
- p.Thr51Ala Single submitter
Uncertain significance 45
- c.119-2A>G Single submitter
- c.*41G>A Single submitter
- p.Ala111Gly Single submitter ⚠
- p.Ala139Glu Single submitter ⚠
- p.Ala144Thr Single submitter ⚠
- p.Ala247Thr Single submitter ⚠
- p.Ala32Ser Single submitter ⚠
- p.Ala78Gly Single submitter ⚠
- p.Ala78Ser Single submitter ⚠
- p.Arg246Cys Single submitter ⚠
- p.Arg246His Single submitter ⚠
- p.Arg268Lys Single submitter ⚠
- p.Arg295His Single submitter ⚠
- p.Arg333Cys Single submitter ⚠
- p.Arg93His Single submitter ⚠
- p.Asn161Ser Single submitter ⚠
- p.Asn344Ser Single submitter ⚠
- p.Asp203Asn Single submitter ⚠
- p.Glu191Ala Single submitter ⚠
- p.Gly289Val Single submitter ⚠
- p.Gly317Arg Single submitter ⚠
- p.Ile116Val Single submitter ⚠
- p.Ile282Met Single submitter ⚠
- p.Leu176Ser Single submitter ⚠
- p.Leu190Val Single submitter ⚠
- p.Met219Val Single submitter ⚠
- p.Met299Arg Single submitter ⚠
- p.Phe212Leu Single submitter ⚠
- p.Phe221Leu Single submitter ⚠
- p.Phe98Ser Single submitter ⚠
- p.Pro281Leu Single submitter ⚠
- p.Pro321Arg Single submitter ⚠
- p.Thr198Lys Single submitter ⚠
- p.Thr198Met Single submitter ⚠
- p.Thr249Met Single submitter ⚠
- p.Thr294Ala Single submitter ⚠
- p.Thr5Arg Single submitter ⚠
- p.Trp28Cys Single submitter ⚠
- p.Tyr127His Single submitter ⚠
- p.Tyr168His Single submitter ⚠
- p.Tyr69Phe Single submitter
- p.Val185Leu Single submitter ⚠
- p.Val185Met Single submitter ⚠
- p.Val210Ile Single submitter ⚠
- p.Val34Met Single submitter ⚠