ZDHHC7 — 40 ClinVar variants
All ClinVar germline ZDHHC7 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 34 flagged for review →
1 Likely benign · 39 Uncertain significance
Full ZDHHC7 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 34
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 27
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- ZDHHC7 p.Ala143Val Uncertain significance Single submitter
- ZDHHC7 p.Arg142Cys Uncertain significance Single submitter
- ZDHHC7 p.Arg202Gln Uncertain significance Single submitter
- ZDHHC7 p.Arg38Gln Uncertain significance Single submitter
- ZDHHC7 p.Arg43Cys Uncertain significance Single submitter
- ZDHHC7 p.Arg43His Uncertain significance Single submitter
- ZDHHC7 p.Asp24Glu Uncertain significance Single submitter
- ZDHHC7 p.Cys50Gly Uncertain significance Single submitter
- ZDHHC7 p.Gln204Leu Uncertain significance Single submitter
- ZDHHC7 p.Glu19Asp Uncertain significance Single submitter
- ZDHHC7 p.Gly111Glu Uncertain significance Single submitter
- ZDHHC7 p.Gly45Ser Uncertain significance Single submitter
- ZDHHC7 p.Gly83Arg Uncertain significance Single submitter
- ZDHHC7 p.His6Gln Uncertain significance Single submitter
- ZDHHC7 p.Ile198Thr Uncertain significance Single submitter
- ZDHHC7 p.Ile85Met Uncertain significance Single submitter
- ZDHHC7 p.Leu71Val Uncertain significance Single submitter
- ZDHHC7 p.Lys115Glu Uncertain significance Single submitter
- ZDHHC7 p.Pro133Ala Uncertain significance Single submitter
- ZDHHC7 p.Pro15Arg Uncertain significance Single submitter
- ZDHHC7 p.Ser185Phe Uncertain significance Single submitter
- ZDHHC7 p.Ser96Ala Uncertain significance Single submitter
- ZDHHC7 p.Thr114Met Uncertain significance Single submitter
- ZDHHC7 p.Trp55Ser Uncertain significance Single submitter
- ZDHHC7 p.Val35Leu Uncertain significance Single submitter
- ZDHHC7 p.Val35Met Uncertain significance Single submitter
- ZDHHC7 p.Val80Leu Uncertain significance Single submitter
Predictors split 7
The independent predictors disagree with each other — read with care.
- ZDHHC7 p.Ala113Thr Uncertain significance Single submitter
- ZDHHC7 p.Arg38Trp Uncertain significance Single submitter
- ZDHHC7 p.Ile129Phe Uncertain significance Single submitter
- ZDHHC7 p.Lys150Glu Uncertain significance Single submitter
- ZDHHC7 p.Phe67Tyr Uncertain significance Single submitter
- ZDHHC7 p.Ser79Cys Uncertain significance Single submitter
- ZDHHC7 p.Ser79Pro Uncertain significance Single submitter
All ZDHHC7 variants
Likely benign 1
- p.Ala59Val Single submitter
Uncertain significance 39
- c.315+1470A>G Single submitter
- c.315+1472A>T Single submitter
- c.315+1516C>A Single submitter
- p.Ala113Thr Single submitter ⚠
- p.Ala143Ser Single submitter
- p.Ala143Val Single submitter ⚠
- p.Arg142Cys Single submitter ⚠
- p.Arg154Gln Single submitter
- p.Arg202Gln Single submitter ⚠
- p.Arg38Gln Single submitter ⚠
- p.Arg38Trp Single submitter ⚠
- p.Arg43Cys Single submitter ⚠
- p.Arg43His Single submitter ⚠
- p.Asp24Glu Single submitter ⚠
- p.Cys50Gly Single submitter ⚠
- p.Gln204Leu Single submitter ⚠
- p.Glu19Asp Single submitter ⚠
- p.Gly111Glu Single submitter ⚠
- p.Gly45Ser Single submitter ⚠
- p.Gly83Arg Single submitter ⚠
- p.His6Gln Single submitter ⚠
- p.Ile129Phe Single submitter ⚠
- p.Ile198Thr Single submitter ⚠
- p.Ile85Met Single submitter ⚠
- p.Leu71Val Single submitter ⚠
- p.Lys115Glu Single submitter ⚠
- p.Lys150Glu Single submitter ⚠
- p.Phe67Tyr Single submitter ⚠
- p.Pro133Ala Single submitter ⚠
- p.Pro15Arg Single submitter ⚠
- p.Ser185Phe Single submitter ⚠
- p.Ser79Cys Single submitter ⚠
- p.Ser79Pro Single submitter ⚠
- p.Ser96Ala Single submitter ⚠
- p.Thr114Met Single submitter ⚠
- p.Trp55Ser Single submitter ⚠
- p.Val35Leu Single submitter ⚠
- p.Val35Met Single submitter ⚠
- p.Val80Leu Single submitter ⚠