ZFP3 — 48 ClinVar variants
All ClinVar germline ZFP3 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 46 flagged for review →
1 Likely benign · 47 Uncertain significance
Full ZFP3 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 46
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 33
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- ZFP3 p.Arg133Ser Uncertain significance Single submitter
- ZFP3 p.Arg133Thr Uncertain significance Single submitter
- ZFP3 p.Arg185Gln Uncertain significance Single submitter
- ZFP3 p.Arg67Lys Uncertain significance Single submitter
- ZFP3 p.Arg86Trp Uncertain significance Single submitter
- ZFP3 p.Cys143Arg Uncertain significance Single submitter
- ZFP3 p.Glu228Ala Uncertain significance Single submitter
- ZFP3 p.Glu285Val Uncertain significance Single submitter
- ZFP3 p.Glu313Gln Uncertain significance Single submitter
- ZFP3 p.Glu4Lys Uncertain significance Single submitter
- ZFP3 p.Glu56Gly Uncertain significance Single submitter
- ZFP3 p.Glu90Asp Uncertain significance Single submitter
- ZFP3 p.Gly119Ala Uncertain significance Single submitter
- ZFP3 p.Gly295Ser Uncertain significance Single submitter
- ZFP3 p.His104Tyr Uncertain significance Single submitter
- ZFP3 p.His155Tyr Uncertain significance Single submitter
- ZFP3 p.His159Asn Uncertain significance Single submitter
- ZFP3 p.His216Arg Uncertain significance Single submitter
- ZFP3 p.His21Arg Uncertain significance Single submitter
- ZFP3 p.His36Tyr Uncertain significance Single submitter
- ZFP3 p.His415Asp Uncertain significance Single submitter
- ZFP3 p.His461Arg Uncertain significance Single submitter
- ZFP3 p.Ile356Thr Uncertain significance Single submitter
- ZFP3 p.Phe76Leu Uncertain significance Single submitter
- ZFP3 p.Ser128Phe Uncertain significance Single submitter
- ZFP3 p.Ser23Pro Uncertain significance Single submitter
- ZFP3 p.Ser51Leu Uncertain significance Single submitter
- ZFP3 p.Ser79Pro Uncertain significance Single submitter
- ZFP3 p.Ser91Arg Uncertain significance Single submitter
- ZFP3 p.Thr345Ser Uncertain significance Single submitter
- ZFP3 p.Thr405Ile Uncertain significance Single submitter
- ZFP3 p.Val102Leu Uncertain significance Single submitter
- ZFP3 p.Val112Ile Uncertain significance Single submitter
Predictors split 13
The independent predictors disagree with each other — read with care.
- ZFP3 p.Ala233Gly Uncertain significance Single submitter
- ZFP3 p.Arg161Ser Uncertain significance Single submitter
- ZFP3 p.Arg326Gln Uncertain significance Single submitter
- ZFP3 p.Arg488Gln Uncertain significance Single submitter
- ZFP3 p.Asn340His Uncertain significance Single submitter
- ZFP3 p.Asp432Gly Uncertain significance Single submitter
- ZFP3 p.Cys255Gly Uncertain significance Single submitter
- ZFP3 p.Cys311Tyr Uncertain significance Single submitter
- ZFP3 p.Gly376Arg Uncertain significance Single submitter
- ZFP3 p.His421Arg Uncertain significance Single submitter
- ZFP3 p.His491Arg Uncertain significance Single submitter
- ZFP3 p.Ile241Met Uncertain significance Single submitter
- ZFP3 p.Leu408Phe Uncertain significance Single submitter
All ZFP3 variants
Likely benign 1
- p.Leu47Ser Single submitter
Uncertain significance 47
- p.Ala233Gly Single submitter ⚠
- p.Arg133Ser Single submitter ⚠
- p.Arg133Thr Single submitter ⚠
- p.Arg161Ser Single submitter ⚠
- p.Arg185Gln Single submitter ⚠
- p.Arg326Gln Single submitter ⚠
- p.Arg488Gln Single submitter ⚠
- p.Arg67Lys Single submitter ⚠
- p.Arg86Trp Single submitter ⚠
- p.Asn340His Single submitter ⚠
- p.Asp432Gly Single submitter ⚠
- p.Cys143Arg Single submitter ⚠
- p.Cys255Gly Single submitter ⚠
- p.Cys311Tyr Single submitter ⚠
- p.Glu228Ala Single submitter ⚠
- p.Glu285Val Single submitter ⚠
- p.Glu313Gln Single submitter ⚠
- p.Glu4Lys Single submitter ⚠
- p.Glu56Gly Single submitter ⚠
- p.Glu90Asp Single submitter ⚠
- p.Gly119Ala Single submitter ⚠
- p.Gly295Ser Single submitter ⚠
- p.Gly376Arg Single submitter ⚠
- p.His104Tyr Single submitter ⚠
- p.His155Tyr Single submitter ⚠
- p.His159Asn Single submitter ⚠
- p.His216Arg Single submitter ⚠
- p.His21Arg Single submitter ⚠
- p.His36Tyr Single submitter ⚠
- p.His415Asp Single submitter ⚠
- p.His421Arg Single submitter ⚠
- p.His461Arg Single submitter ⚠
- p.His491Arg Single submitter ⚠
- p.Ile241Met Single submitter ⚠
- p.Ile356Thr Single submitter ⚠
- p.Leu408Phe Single submitter ⚠
- p.Leu492Phe Single submitter
- p.Phe76Leu Single submitter ⚠
- p.Ser128Phe Single submitter ⚠
- p.Ser23Pro Single submitter ⚠
- p.Ser51Leu Single submitter ⚠
- p.Ser79Pro Single submitter ⚠
- p.Ser91Arg Single submitter ⚠
- p.Thr345Ser Single submitter ⚠
- p.Thr405Ile Single submitter ⚠
- p.Val102Leu Single submitter ⚠
- p.Val112Ile Single submitter ⚠