ZFP91 — 81 ClinVar variants
All ClinVar germline ZFP91 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 81 flagged for review →
81 Uncertain significance
Full ZFP91 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 81
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 72
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- ZFP91 p.Val445Ile Uncertain significance Multiple submitters
- ZFP91 p.Ala468Thr Uncertain significance Single submitter
- ZFP91 p.Ala568Ser Uncertain significance Single submitter
- ZFP91 p.Ala64Thr Uncertain significance Single submitter
- ZFP91 p.Ala67Gly Uncertain significance Single submitter
- ZFP91 p.Ala67Ser Uncertain significance Single submitter
- ZFP91 p.Arg112Gln Uncertain significance Single submitter
- ZFP91 p.Arg150Gln Uncertain significance Single submitter
- ZFP91 p.Arg153His Uncertain significance Single submitter
- ZFP91 p.Arg161Ser Uncertain significance Single submitter
- ZFP91 p.Arg163Leu Uncertain significance Single submitter
- ZFP91 p.Arg172Gln Uncertain significance Single submitter
- ZFP91 p.Arg278Lys Uncertain significance Single submitter
- ZFP91 p.Arg32Gln Uncertain significance Single submitter
- ZFP91 p.Arg56Gln Uncertain significance Single submitter
- ZFP91 p.Arg58Pro Uncertain significance Single submitter
- ZFP91 p.Arg80Gln Uncertain significance Single submitter
- ZFP91 p.Asp134Asn Uncertain significance Single submitter
- ZFP91 p.Asp15Asn Uncertain significance Single submitter
- ZFP91 p.Gln14Glu Uncertain significance Single submitter
- ZFP91 p.Gln179Arg Uncertain significance Single submitter
- ZFP91 p.Gln31Arg Uncertain significance Single submitter
- ZFP91 p.Gln485Leu Uncertain significance Single submitter
- ZFP91 p.Glu17Gly Uncertain significance Single submitter
- ZFP91 p.Glu274Gly Uncertain significance Single submitter
- ZFP91 p.Glu545Lys Uncertain significance Single submitter
- ZFP91 p.Gly176Ser Uncertain significance Single submitter
- ZFP91 p.Gly18Arg Uncertain significance Single submitter
- ZFP91 p.Gly18Glu Uncertain significance Single submitter
- ZFP91 p.Gly18Val Uncertain significance Single submitter
- ZFP91 p.Gly19Glu Uncertain significance Single submitter
- ZFP91 p.Gly204Asp Uncertain significance Single submitter
- ZFP91 p.Gly204Ser Uncertain significance Single submitter
- ZFP91 p.Gly43Glu Uncertain significance Single submitter
- ZFP91 p.Gly489Val Uncertain significance Single submitter
- ZFP91 p.Gly505Glu Uncertain significance Single submitter
- ZFP91 p.Gly53Arg Uncertain significance Single submitter
- ZFP91 p.Gly569Arg Uncertain significance Single submitter
- ZFP91 p.Gly93Ala Uncertain significance Single submitter
- ZFP91 p.Ile143Phe Uncertain significance Single submitter
- ZFP91 p.Ile553Leu Uncertain significance Single submitter
- ZFP91 p.Lys109Arg Uncertain significance Single submitter
- ZFP91 p.Lys126Glu Uncertain significance Single submitter
- ZFP91 p.Lys364Arg Uncertain significance Single submitter
- ZFP91 p.Met529Ile Uncertain significance Single submitter
- ZFP91 p.Pro111Ser Uncertain significance Single submitter
- ZFP91 p.Pro148Leu Uncertain significance Single submitter
- ZFP91 p.Pro283Leu Uncertain significance Single submitter
- ZFP91 p.Pro33Ser Uncertain significance Single submitter
- ZFP91 p.Pro34Arg Uncertain significance Single submitter
- ZFP91 p.Pro34Leu Uncertain significance Single submitter
- ZFP91 p.Pro454Thr Uncertain significance Single submitter
- ZFP91 p.Pro84Leu Uncertain significance Single submitter
- ZFP91 p.Pro96Ala Uncertain significance Single submitter
- ZFP91 p.Pro96Leu Uncertain significance Single submitter
- ZFP91 p.Ser103Ala Uncertain significance Single submitter
- ZFP91 p.Ser158Phe Uncertain significance Single submitter
- ZFP91 p.Ser160Phe Uncertain significance Single submitter
- ZFP91 p.Ser173Pro Uncertain significance Single submitter
- ZFP91 p.Ser47Asn Uncertain significance Single submitter
- ZFP91 p.Ser487Leu Uncertain significance Single submitter
- ZFP91 p.Ser538Asn Uncertain significance Single submitter
- ZFP91 p.Ser85Arg Uncertain significance Single submitter
- ZFP91 p.Thr165Ile Uncertain significance Single submitter
- ZFP91 p.Thr168Ala Uncertain significance Single submitter
- ZFP91 p.Thr45Pro Uncertain significance Single submitter
- ZFP91 p.Thr484Met Uncertain significance Single submitter
- ZFP91 p.Thr503Ala Uncertain significance Single submitter
- ZFP91 p.Thr523Lys Uncertain significance Single submitter
- ZFP91 p.Thr523Met Uncertain significance Single submitter
- ZFP91 p.Tyr235His Uncertain significance Single submitter
- ZFP91 p.Val105Phe Uncertain significance Single submitter
Predictors split 9
The independent predictors disagree with each other — read with care.
- ZFP91 p.Arg150Trp Uncertain significance Single submitter
- ZFP91 p.Arg291Gln Uncertain significance Single submitter
- ZFP91 p.Arg71Trp Uncertain significance Single submitter
- ZFP91 p.Arg79Trp Uncertain significance Single submitter
- ZFP91 p.Cys182Ser Uncertain significance Single submitter
- ZFP91 p.Gly477Asp Uncertain significance Single submitter
- ZFP91 p.Gly555Cys Uncertain significance Single submitter
- ZFP91 p.Ile475Thr Uncertain significance Single submitter
- ZFP91 p.Ser101Phe Uncertain significance Single submitter
All ZFP91 variants
Uncertain significance 81
- p.Val445Ile Multiple submitters ⚠
- p.Ala468Thr Single submitter ⚠
- p.Ala568Ser Single submitter ⚠
- p.Ala64Thr Single submitter ⚠
- p.Ala67Gly Single submitter ⚠
- p.Ala67Ser Single submitter ⚠
- p.Arg112Gln Single submitter ⚠
- p.Arg150Gln Single submitter ⚠
- p.Arg150Trp Single submitter ⚠
- p.Arg153His Single submitter ⚠
- p.Arg161Ser Single submitter ⚠
- p.Arg163Leu Single submitter ⚠
- p.Arg172Gln Single submitter ⚠
- p.Arg278Lys Single submitter ⚠
- p.Arg291Gln Single submitter ⚠
- p.Arg32Gln Single submitter ⚠
- p.Arg56Gln Single submitter ⚠
- p.Arg58Pro Single submitter ⚠
- p.Arg71Trp Single submitter ⚠
- p.Arg79Trp Single submitter ⚠
- p.Arg80Gln Single submitter ⚠
- p.Asp134Asn Single submitter ⚠
- p.Asp15Asn Single submitter ⚠
- p.Cys182Ser Single submitter ⚠
- p.Gln14Glu Single submitter ⚠
- p.Gln179Arg Single submitter ⚠
- p.Gln31Arg Single submitter ⚠
- p.Gln485Leu Single submitter ⚠
- p.Glu17Gly Single submitter ⚠
- p.Glu274Gly Single submitter ⚠
- p.Glu545Lys Single submitter ⚠
- p.Gly176Ser Single submitter ⚠
- p.Gly18Arg Single submitter ⚠
- p.Gly18Glu Single submitter ⚠
- p.Gly18Val Single submitter ⚠
- p.Gly19Glu Single submitter ⚠
- p.Gly204Asp Single submitter ⚠
- p.Gly204Ser Single submitter ⚠
- p.Gly43Glu Single submitter ⚠
- p.Gly477Asp Single submitter ⚠
- p.Gly489Val Single submitter ⚠
- p.Gly505Glu Single submitter ⚠
- p.Gly53Arg Single submitter ⚠
- p.Gly555Cys Single submitter ⚠
- p.Gly569Arg Single submitter ⚠
- p.Gly93Ala Single submitter ⚠
- p.Ile143Phe Single submitter ⚠
- p.Ile475Thr Single submitter ⚠
- p.Ile553Leu Single submitter ⚠
- p.Lys109Arg Single submitter ⚠
- p.Lys126Glu Single submitter ⚠
- p.Lys364Arg Single submitter ⚠
- p.Met529Ile Single submitter ⚠
- p.Pro111Ser Single submitter ⚠
- p.Pro148Leu Single submitter ⚠
- p.Pro283Leu Single submitter ⚠
- p.Pro33Ser Single submitter ⚠
- p.Pro34Arg Single submitter ⚠
- p.Pro34Leu Single submitter ⚠
- p.Pro454Thr Single submitter ⚠
- p.Pro84Leu Single submitter ⚠
- p.Pro96Ala Single submitter ⚠
- p.Pro96Leu Single submitter ⚠
- p.Ser101Phe Single submitter ⚠
- p.Ser103Ala Single submitter ⚠
- p.Ser158Phe Single submitter ⚠
- p.Ser160Phe Single submitter ⚠
- p.Ser173Pro Single submitter ⚠
- p.Ser47Asn Single submitter ⚠
- p.Ser487Leu Single submitter ⚠
- p.Ser538Asn Single submitter ⚠
- p.Ser85Arg Single submitter ⚠
- p.Thr165Ile Single submitter ⚠
- p.Thr168Ala Single submitter ⚠
- p.Thr45Pro Single submitter ⚠
- p.Thr484Met Single submitter ⚠
- p.Thr503Ala Single submitter ⚠
- p.Thr523Lys Single submitter ⚠
- p.Thr523Met Single submitter ⚠
- p.Tyr235His Single submitter ⚠
- p.Val105Phe Single submitter ⚠