ZKSCAN2 — 180 ClinVar variants

All ClinVar germline ZKSCAN2 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 166 flagged for review →

14 Likely benign · 166 Uncertain significance

Full ZKSCAN2 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions

⚑ Evidence disagreements 166

Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.

Predictors lean, ClinVar uncertain 144

ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.

Predictors split 22

The independent predictors disagree with each other — read with care.

All ZKSCAN2 variants

Likely benign 14

p.Ala149Val Single submitter
p.Ala321Thr Single submitter
p.Ala451Gly Single submitter
p.Arg185Gln Single submitter
p.Arg255Gln Single submitter
p.Arg280Gln Single submitter
p.His486Arg Single submitter
p.Leu290Val Single submitter
p.Lys46Arg Single submitter
p.Val234Met Single submitter
p.Val23Met Single submitter
p.Val265Met Single submitter
p.Val306Ile Single submitter
p.Val569Met Single submitter

Uncertain significance 166

p.Ala103Thr Single submitter ⚠
p.Ala166Ser Single submitter ⚠
p.Ala204Thr Single submitter ⚠
p.Ala223Ser Single submitter ⚠
p.Ala271Val Single submitter ⚠
p.Ala417Thr Single submitter ⚠
p.Ala466Thr Single submitter ⚠
p.Ala535Thr Single submitter ⚠
p.Ala589Gly Single submitter ⚠
p.Ala918Ser Single submitter ⚠
p.Arg129Lys Single submitter ⚠
p.Arg131Ile Single submitter ⚠
p.Arg140Gln Single submitter ⚠
p.Arg197Gln Single submitter ⚠
p.Arg220Gln Single submitter ⚠
p.Arg280Trp Single submitter ⚠
p.Arg302Gln Single submitter ⚠
p.Arg359Cys Single submitter ⚠
p.Arg359His Single submitter ⚠
p.Arg431Leu Single submitter ⚠
p.Arg446Ile Single submitter ⚠
p.Arg446Thr Single submitter ⚠
p.Arg513Cys Single submitter ⚠
p.Arg516Gln Single submitter ⚠
p.Arg526Trp Single submitter ⚠
p.Arg562His Single submitter ⚠
p.Arg637Thr Single submitter ⚠
p.Arg762His Single submitter ⚠
p.Arg766Gly Single submitter ⚠
p.Arg766Trp Single submitter ⚠
p.Arg795Ile Single submitter ⚠
p.Arg832Ile Single submitter ⚠
p.Arg878Gln Single submitter ⚠
p.Arg903Gln Single submitter ⚠
p.Arg906Gln Single submitter ⚠
p.Arg923His Single submitter ⚠
p.Asn304Ser Single submitter ⚠
p.Asn409Thr Single submitter ⚠
p.Asn773Tyr Single submitter ⚠
p.Asp10Gly Single submitter ⚠
p.Asp39Gly Single submitter ⚠
p.Asp423His Single submitter ⚠
p.Asp632Glu Single submitter ⚠
p.Asp699Val Single submitter ⚠
p.Cys109Tyr Single submitter ⚠
p.Cys18Arg Single submitter ⚠
p.Cys899Tyr Single submitter ⚠
p.Cys920Tyr Single submitter ⚠
p.Cys951Arg Single submitter ⚠
p.Gln132His Single submitter ⚠
p.Gln163Glu Single submitter ⚠
p.Gln645Arg Single submitter ⚠
p.Gln713Pro Single submitter ⚠
p.Gln722Arg Single submitter ⚠
p.Gln794Arg Single submitter ⚠
p.Gln8Lys Single submitter ⚠
p.Glu14Val Single submitter ⚠
p.Glu151Lys Single submitter ⚠
p.Glu161Lys Single submitter ⚠
p.Glu16Gly Single submitter ⚠
p.Glu171Asp Single submitter ⚠
p.Glu181Lys Single submitter ⚠
p.Glu282Val Single submitter ⚠
p.Glu28Lys Single submitter ⚠
p.Glu379Gly Single submitter ⚠
p.Glu597Asp Single submitter ⚠
p.Glu610Asp Single submitter ⚠
p.Glu615Lys Single submitter ⚠
p.Glu636Gly Single submitter ⚠
p.Glu640Lys Single submitter ⚠
p.Glu646Val Single submitter ⚠
p.Glu670Lys Single submitter ⚠
p.Glu688Gly Single submitter ⚠
p.Glu800Lys Single submitter ⚠
p.Glu86Gln Single submitter ⚠
p.Glu935Lys Single submitter ⚠
p.Gly291Val Single submitter ⚠
p.Gly37Arg Single submitter ⚠
p.Gly37Glu Single submitter ⚠
p.Gly501Val Single submitter ⚠
p.Gly607Ala Single submitter ⚠
p.Gly607Arg Single submitter ⚠
p.Gly607Val Single submitter ⚠
p.Gly618Val Single submitter ⚠
p.Gly665Arg Single submitter ⚠
p.Gly744Glu Single submitter ⚠
p.Gly785Val Single submitter ⚠
p.Gly834Arg Single submitter ⚠
p.Gly883Val Single submitter ⚠
p.His457Arg Single submitter ⚠
p.His937Arg Single submitter ⚠
p.Ile247Met Single submitter ⚠
p.Ile278Val Single submitter ⚠
p.Ile442Thr Single submitter ⚠
p.Ile452Met Single submitter ⚠
p.Ile485Val Single submitter ⚠
p.Ile609Val Single submitter ⚠
p.Ile668Val Single submitter ⚠
p.Ile675Met Single submitter ⚠
p.Ile709Val Single submitter ⚠
p.Ile824Leu Single submitter ⚠
p.Ile847Leu Single submitter ⚠
p.Ile847Thr Single submitter ⚠
p.Leu13Met Single submitter ⚠
p.Leu146Val Single submitter ⚠
p.Leu175Phe Single submitter ⚠
p.Leu290Pro Single submitter ⚠
p.Leu495Phe Single submitter ⚠
p.Leu751Val Single submitter ⚠
p.Leu846Pro Single submitter ⚠
p.Leu97Ser Single submitter ⚠
p.Lys107Arg Single submitter ⚠
p.Lys107Thr Single submitter ⚠
p.Lys186Asn Single submitter ⚠
p.Lys285Asn Single submitter ⚠
p.Lys297Glu Single submitter ⚠
p.Lys563Asn Single submitter ⚠
p.Lys691Thr Single submitter ⚠
p.Lys776Gln Single submitter ⚠
p.Lys829Thr Single submitter ⚠
p.Lys957Glu Single submitter ⚠
p.Met638Val Single submitter ⚠
p.Phe155Val Single submitter ⚠
p.Phe418Leu Single submitter ⚠
p.Pro12Ser Single submitter ⚠
p.Pro157Leu Single submitter ⚠
p.Pro248Leu Single submitter ⚠
p.Pro287Leu Single submitter ⚠
p.Pro590Ser Single submitter ⚠
p.Pro725Ser Single submitter ⚠
p.Pro741Ala Single submitter ⚠
p.Pro830Ser Single submitter ⚠
p.Pro914Leu Single submitter ⚠
p.Pro944Leu Single submitter ⚠
p.Ser112Asn Single submitter ⚠
p.Ser144Cys Single submitter ⚠
p.Ser295Phe Single submitter ⚠
p.Ser303Thr Single submitter ⚠
p.Ser38Trp Single submitter ⚠
p.Ser459Asn Single submitter ⚠
p.Ser496Cys Single submitter ⚠
p.Ser528Arg Single submitter ⚠
p.Ser528Ile Single submitter ⚠
p.Ser593Ile Single submitter ⚠
p.Ser600Pro Single submitter ⚠
p.Ser639Asn Single submitter ⚠
p.Ser667Gly Single submitter ⚠
p.Ser811Thr Single submitter ⚠
p.Ser871Arg Single submitter ⚠
p.Ser895Cys Single submitter ⚠
p.Thr274Ala Single submitter ⚠
p.Thr289Ser Single submitter ⚠
p.Thr900Arg Single submitter ⚠
p.Thr95Ala Single submitter ⚠
p.Trp325Arg Single submitter ⚠
p.Trp714Arg Single submitter ⚠
p.Tyr859Cys Single submitter ⚠
p.Tyr887Cys Single submitter ⚠
p.Val138Leu Single submitter ⚠
p.Val138Met Single submitter ⚠
p.Val244Gly Single submitter ⚠
p.Val461Leu Single submitter ⚠
p.Val498Met Single submitter ⚠
p.Val611Phe Single submitter ⚠
p.Val629Leu Single submitter ⚠
p.Val644Leu Single submitter ⚠