ZNF277 — 54 ClinVar variants
All ClinVar germline ZNF277 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 40 flagged for review →
1 Conflicting · 1 Benign · 8 Likely benign · 44 Uncertain significance
Full ZNF277 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 40
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 31
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- ZNF277 p.Ala125Gly Uncertain significance Single submitter
- ZNF277 p.Ala302Ser Uncertain significance Single submitter
- ZNF277 p.Ala419Gly Uncertain significance Single submitter
- ZNF277 p.Arg147Ser Uncertain significance Single submitter
- ZNF277 p.Arg166Gln Uncertain significance Single submitter
- ZNF277 p.Arg351Gln Uncertain significance Single submitter
- ZNF277 p.Arg351Trp Uncertain significance Single submitter
- ZNF277 p.Arg358Ser Uncertain significance Single submitter
- ZNF277 p.Asn348Thr Uncertain significance Single submitter
- ZNF277 p.Asp323Tyr Uncertain significance Single submitter
- ZNF277 p.Cys175Ser Uncertain significance Single submitter
- ZNF277 p.Glu129Gln Uncertain significance Single submitter
- ZNF277 p.Glu308Ala Uncertain significance Single submitter
- ZNF277 p.Glu315Asp Uncertain significance Single submitter
- ZNF277 p.Gly25Glu Uncertain significance Single submitter
- ZNF277 p.Gly48Asp Uncertain significance Single submitter
- ZNF277 p.Gly54Asp Uncertain significance Single submitter
- ZNF277 p.His248Tyr Uncertain significance Single submitter
- ZNF277 p.Ile85Val Uncertain significance Single submitter
- ZNF277 p.Leu146Phe Uncertain significance Single submitter
- ZNF277 p.Leu40Phe Uncertain significance Single submitter
- ZNF277 p.Leu450Pro Uncertain significance Single submitter
- ZNF277 p.Lys231Thr Uncertain significance Single submitter
- ZNF277 p.Lys331Asn Uncertain significance Single submitter
- ZNF277 p.Pro111His Uncertain significance Single submitter
- ZNF277 p.Ser117Asn Uncertain significance Single submitter
- ZNF277 p.Ser413Thr Uncertain significance Single submitter
- ZNF277 p.Ser57Cys Uncertain significance Single submitter
- ZNF277 p.Thr433Pro Uncertain significance Single submitter
- ZNF277 p.Thr6Ile Uncertain significance Single submitter
- ZNF277 p.Trp292Ser Uncertain significance Single submitter
Predictors split 9
The independent predictors disagree with each other — read with care.
- ZNF277 p.Asn191Lys Uncertain significance Single submitter
- ZNF277 p.Asn265Ser Uncertain significance Single submitter
- ZNF277 p.Asp280Tyr Uncertain significance Single submitter
- ZNF277 p.Glu131Lys Conflicting Single submitter
- ZNF277 p.Glu212Gly Uncertain significance Single submitter
- ZNF277 p.Glu275Val Uncertain significance Single submitter
- ZNF277 p.Phe327Leu Uncertain significance Single submitter
- ZNF277 p.Pro253Arg Uncertain significance Single submitter
- ZNF277 p.Tyr102Phe Uncertain significance Single submitter
All ZNF277 variants
Conflicting classifications of pathogenicity 1
- p.Glu131Lys Single submitter ⚠
Benign 1
- p.Thr169fs Single submitter
Likely benign 8
- c.92-4C>T Single submitter
- c.92-7A>T Single submitter
- c.-1A>G Single submitter
- p.Asn170Ser Single submitter
- p.Asp290= Single submitter
- p.Glu165= Single submitter
- p.Thr379Ala Single submitter
- p.Thr390= Single submitter
Uncertain significance 44
- p.Ala125Gly Single submitter ⚠
- p.Ala302Ser Single submitter ⚠
- p.Ala419Gly Single submitter ⚠
- p.Arg147Ser Single submitter ⚠
- p.Arg166Gln Single submitter ⚠
- p.Arg249His Single submitter
- p.Arg351Gln Single submitter ⚠
- p.Arg351Trp Single submitter ⚠
- p.Arg358Ser Single submitter ⚠
- p.Asn191Lys Single submitter ⚠
- p.Asn265Ser Single submitter ⚠
- p.Asn348Thr Single submitter ⚠
- p.Asp280Tyr Single submitter ⚠
- p.Asp323Tyr Single submitter ⚠
- p.Cys175Ser Single submitter ⚠
- p.Glu129Gln Single submitter ⚠
- p.Glu212Gly Single submitter ⚠
- p.Glu275Val Single submitter ⚠
- p.Glu308Ala Single submitter ⚠
- p.Glu315Asp Single submitter ⚠
- p.Gly25Glu Single submitter ⚠
- p.Gly48Asp Single submitter ⚠
- p.Gly54Asp Single submitter ⚠
- p.His248Tyr Single submitter ⚠
- p.Ile85Val Single submitter ⚠
- p.Leu146His Single submitter
- p.Leu146Phe Single submitter ⚠
- p.Leu155Val Single submitter
- p.Leu40Phe Single submitter ⚠
- p.Leu450Pro Single submitter ⚠
- p.Lys231Thr Single submitter ⚠
- p.Lys331Asn Single submitter ⚠
- p.Phe327Leu Single submitter ⚠
- p.Pro111His Single submitter ⚠
- p.Pro253Arg Single submitter ⚠
- p.Pro39Leu Single submitter
- p.Ser117Asn Single submitter ⚠
- p.Ser413Thr Single submitter ⚠
- p.Ser57Cys Single submitter ⚠
- p.Thr433Pro Single submitter ⚠
- p.Thr6Ile Single submitter ⚠
- p.Trp292Ser Single submitter ⚠
- p.Tyr102Phe Single submitter ⚠
- c.466-2289_557+1772del No assertion criteria