ZNF787 — 54 ClinVar variants
All ClinVar germline ZNF787 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 49 flagged for review →
5 Likely benign · 49 Uncertain significance
Full ZNF787 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 49
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 47
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- ZNF787 p.Ala226Val Uncertain significance Single submitter
- ZNF787 p.Ala228Val Uncertain significance Single submitter
- ZNF787 p.Ala229Val Uncertain significance Single submitter
- ZNF787 p.Ala248Gly Uncertain significance Single submitter
- ZNF787 p.Ala253Ser Uncertain significance Single submitter
- ZNF787 p.Ala254Thr Uncertain significance Single submitter
- ZNF787 p.Ala262Thr Uncertain significance Single submitter
- ZNF787 p.Ala264Ser Uncertain significance Single submitter
- ZNF787 p.Ala264Thr Uncertain significance Single submitter
- ZNF787 p.Ala267Pro Uncertain significance Single submitter
- ZNF787 p.Ala267Ser Uncertain significance Single submitter
- ZNF787 p.Ala267Thr Uncertain significance Single submitter
- ZNF787 p.Ala274Pro Uncertain significance Single submitter
- ZNF787 p.Ala276Val Uncertain significance Single submitter
- ZNF787 p.Ala293Val Uncertain significance Single submitter
- ZNF787 p.Ala51Val Uncertain significance Single submitter
- ZNF787 p.Ala64Pro Uncertain significance Single submitter
- ZNF787 p.Ala97Gly Uncertain significance Single submitter
- ZNF787 p.Ala97Thr Uncertain significance Single submitter
- ZNF787 p.Arg113Gln Uncertain significance Single submitter
- ZNF787 p.Arg272Gln Uncertain significance Single submitter
- ZNF787 p.Arg4Leu Uncertain significance Single submitter
- ZNF787 p.Asp305Glu Uncertain significance Single submitter
- ZNF787 p.Asp33Glu Uncertain significance Single submitter
- ZNF787 p.Gln302Arg Uncertain significance Single submitter
- ZNF787 p.Gln85Arg Uncertain significance Single submitter
- ZNF787 p.Glu16Lys Uncertain significance Single submitter
- ZNF787 p.Glu224Lys Uncertain significance Single submitter
- ZNF787 p.Glu5Lys Uncertain significance Single submitter
- ZNF787 p.Gly186Ser Uncertain significance Single submitter
- ZNF787 p.Gly250Ser Uncertain significance Single submitter
- ZNF787 p.Gly379Arg Uncertain significance Single submitter
- ZNF787 p.Gly55Ala Uncertain significance Single submitter
- ZNF787 p.Ile233Val Uncertain significance Single submitter
- ZNF787 p.Leu125Phe Uncertain significance Single submitter
- ZNF787 p.Lys265Glu Uncertain significance Single submitter
- ZNF787 p.Met259Ile Uncertain significance Single submitter
- ZNF787 p.Met259Val Uncertain significance Single submitter
- ZNF787 p.Pro10Leu Uncertain significance Single submitter
- ZNF787 p.Pro12Leu Uncertain significance Single submitter
- ZNF787 p.Ser15Phe Uncertain significance Single submitter
- ZNF787 p.Ser162Gly Uncertain significance Single submitter
- ZNF787 p.Ser271Leu Uncertain significance Single submitter
- ZNF787 p.Val179Leu Uncertain significance Single submitter
- ZNF787 p.Val237Met Uncertain significance Single submitter
- ZNF787 p.Val246Gly Uncertain significance Single submitter
-
ZNF787 p.Glu362Asp
Uncertain significance
No assertion criteria
Moebius syndrome
Predictors split 2
The independent predictors disagree with each other — read with care.
All ZNF787 variants
Likely benign 5
- c.79+294G>A Single submitter
- p.Cys183= Single submitter
- p.Leu125Ser Single submitter
- p.Thr151Ala Single submitter
- p.Val227Ala Single submitter
Uncertain significance 49
- p.Ala226Val Single submitter ⚠
- p.Ala228Val Single submitter ⚠
- p.Ala229Val Single submitter ⚠
- p.Ala248Gly Single submitter ⚠
- p.Ala253Ser Single submitter ⚠
- p.Ala254Thr Single submitter ⚠
- p.Ala262Thr Single submitter ⚠
- p.Ala264Ser Single submitter ⚠
- p.Ala264Thr Single submitter ⚠
- p.Ala267Pro Single submitter ⚠
- p.Ala267Ser Single submitter ⚠
- p.Ala267Thr Single submitter ⚠
- p.Ala274Pro Single submitter ⚠
- p.Ala276Val Single submitter ⚠
- p.Ala293Val Single submitter ⚠
- p.Ala51Val Single submitter ⚠
- p.Ala64Pro Single submitter ⚠
- p.Ala97Gly Single submitter ⚠
- p.Ala97Thr Single submitter ⚠
- p.Arg113Gln Single submitter ⚠
- p.Arg272Gln Single submitter ⚠
- p.Arg4Leu Single submitter ⚠
- p.Asp305Glu Single submitter ⚠
- p.Asp33Glu Single submitter ⚠
- p.Gln302Arg Single submitter ⚠
- p.Gln85Arg Single submitter ⚠
- p.Glu16Lys Single submitter ⚠
- p.Glu224Lys Single submitter ⚠
- p.Glu5Lys Single submitter ⚠
- p.Gly186Ser Single submitter ⚠
- p.Gly250Ser Single submitter ⚠
- p.Gly379Arg Single submitter ⚠
- p.Gly55Ala Single submitter ⚠
- p.Ile233Val Single submitter ⚠
- p.Leu125Phe Single submitter ⚠
- p.Lys211Asn Single submitter ⚠
- p.Lys265Glu Single submitter ⚠
- p.Met259Ile Single submitter ⚠
- p.Met259Val Single submitter ⚠
- p.Pro10Leu Single submitter ⚠
- p.Pro12Leu Single submitter ⚠
- p.Ser15Phe Single submitter ⚠
- p.Ser162Gly Single submitter ⚠
- p.Ser188Ile Single submitter ⚠
- p.Ser271Leu Single submitter ⚠
- p.Val179Leu Single submitter ⚠
- p.Val237Met Single submitter ⚠
- p.Val246Gly Single submitter ⚠
- p.Glu362Asp No assertion criteria Moebius syndrome ⚠