ZRANB2 — 29 ClinVar variants
All ClinVar germline ZRANB2 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 27 flagged for review →
29 Uncertain significance
Full ZRANB2 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 27
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 17
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- ZRANB2 p.Ala66Thr Uncertain significance Single submitter
- ZRANB2 p.Arg203His Uncertain significance Single submitter
- ZRANB2 p.Arg207Gln Uncertain significance Single submitter
- ZRANB2 p.Arg212Pro Uncertain significance Single submitter
- ZRANB2 p.Arg216His Uncertain significance Single submitter
- ZRANB2 p.Arg252His Uncertain significance Single submitter
- ZRANB2 p.Arg289His Uncertain significance Single submitter
- ZRANB2 p.Arg304Lys Uncertain significance Single submitter
- ZRANB2 p.Arg36Gln Uncertain significance Single submitter
- ZRANB2 p.Asn5Ser Uncertain significance Single submitter
- ZRANB2 p.Asp170Glu Uncertain significance Single submitter
- ZRANB2 p.His210Arg Uncertain significance Single submitter
- ZRANB2 p.His312Tyr Uncertain significance Single submitter
- ZRANB2 p.His320Asn Uncertain significance Single submitter
- ZRANB2 p.His320Leu Uncertain significance Single submitter
- ZRANB2 p.Pro308Ser Uncertain significance Single submitter
- ZRANB2 p.Val148Ile Uncertain significance Single submitter
Predictors split 10
The independent predictors disagree with each other — read with care.
- ZRANB2 p.Arg216Cys Uncertain significance Single submitter
- ZRANB2 p.Arg248Leu Uncertain significance Single submitter
- ZRANB2 p.Arg272Ile Uncertain significance Single submitter
- ZRANB2 p.Arg298Cys Uncertain significance Single submitter
- ZRANB2 p.Arg311Cys Uncertain significance Single submitter
- ZRANB2 p.Arg324Cys Uncertain significance Single submitter
- ZRANB2 p.Ser237Leu Uncertain significance Single submitter
- ZRANB2 p.Ser256Thr Uncertain significance Single submitter
- ZRANB2 p.Ser314Pro Uncertain significance Single submitter
- ZRANB2 p.Ser326Cys Uncertain significance Single submitter
All ZRANB2 variants
Uncertain significance 29
- p.Ala66Thr Single submitter ⚠
- p.Arg203His Single submitter ⚠
- p.Arg207Gln Single submitter ⚠
- p.Arg212Pro Single submitter ⚠
- p.Arg216Cys Single submitter ⚠
- p.Arg216His Single submitter ⚠
- p.Arg248Leu Single submitter ⚠
- p.Arg252His Single submitter ⚠
- p.Arg272Ile Single submitter ⚠
- p.Arg289His Single submitter ⚠
- p.Arg291Ile Single submitter
- p.Arg298Cys Single submitter ⚠
- p.Arg304Lys Single submitter ⚠
- p.Arg311Cys Single submitter ⚠
- p.Arg324Cys Single submitter ⚠
- p.Arg36Gln Single submitter ⚠
- p.Asn5Ser Single submitter ⚠
- p.Asp170Glu Single submitter ⚠
- p.His210Arg Single submitter ⚠
- p.His312Tyr Single submitter ⚠
- p.His320Asn Single submitter ⚠
- p.His320Leu Single submitter ⚠
- p.Pro308Ser Single submitter ⚠
- p.Ser237Leu Single submitter ⚠
- p.Ser237Trp Single submitter
- p.Ser256Thr Single submitter ⚠
- p.Ser314Pro Single submitter ⚠
- p.Ser326Cys Single submitter ⚠
- p.Val148Ile Single submitter ⚠