ZW10 — 99 ClinVar variants
All ClinVar germline ZW10 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 90 flagged for review →
4 Likely benign · 95 Uncertain significance
Full ZW10 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 90
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 74
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- ZW10 p.Ala327Thr Uncertain significance Single submitter
- ZW10 p.Ala392Ser Uncertain significance Single submitter
- ZW10 p.Ala490Thr Uncertain significance Single submitter
- ZW10 p.Ala505Thr Uncertain significance Single submitter
- ZW10 p.Ala538Thr Uncertain significance Single submitter
- ZW10 p.Ala56Val Uncertain significance Single submitter
- ZW10 p.Ala652Val Uncertain significance Single submitter
- ZW10 p.Ala751Val Uncertain significance Single submitter
- ZW10 p.Ala772Glu Uncertain significance Single submitter
- ZW10 p.Ala774Thr Uncertain significance Single submitter
- ZW10 p.Arg137Cys Uncertain significance Single submitter
- ZW10 p.Arg151Gly Uncertain significance Single submitter
- ZW10 p.Arg276His Uncertain significance Single submitter
- ZW10 p.Arg393Cys Uncertain significance Single submitter
- ZW10 p.Arg478Gly Uncertain significance Single submitter
- ZW10 p.Arg478His Uncertain significance Single submitter
- ZW10 p.Arg562Cys Uncertain significance Single submitter
- ZW10 p.Arg562His Uncertain significance Single submitter
- ZW10 p.Arg627Gln Uncertain significance Single submitter
- ZW10 p.Arg635Lys Uncertain significance Single submitter
- ZW10 p.Arg762His Uncertain significance Single submitter
- ZW10 p.Asn401His Uncertain significance Single submitter
- ZW10 p.Asn401Lys Uncertain significance Single submitter
- ZW10 p.Asn767His Uncertain significance Single submitter
- ZW10 p.Asp155Tyr Uncertain significance Single submitter
- ZW10 p.Asp428Ala Uncertain significance Single submitter
- ZW10 p.Asp440Gly Uncertain significance Single submitter
- ZW10 p.Asp442Tyr Uncertain significance Single submitter
- ZW10 p.Cys568Arg Uncertain significance Single submitter
- ZW10 p.Cys588Tyr Uncertain significance Single submitter
- ZW10 p.Glu121Gly Uncertain significance Single submitter
- ZW10 p.Glu205Lys Uncertain significance Single submitter
- ZW10 p.Glu267Lys Uncertain significance Single submitter
- ZW10 p.Glu278Ala Uncertain significance Single submitter
- ZW10 p.Glu462Gln Uncertain significance Single submitter
- ZW10 p.Glu529Lys Uncertain significance Single submitter
- ZW10 p.Glu692Lys Uncertain significance Single submitter
- ZW10 p.Glu769Asp Uncertain significance Single submitter
- ZW10 p.Glu78Lys Uncertain significance Single submitter
- ZW10 p.Gly90Ser Uncertain significance Single submitter
- ZW10 p.His517Tyr Uncertain significance Single submitter
- ZW10 p.His550Asp Uncertain significance Single submitter
- ZW10 p.His557Tyr Uncertain significance Single submitter
- ZW10 p.Ile185Leu Uncertain significance Single submitter
- ZW10 p.Ile185Thr Uncertain significance Single submitter
- ZW10 p.Ile395Val Uncertain significance Single submitter
- ZW10 p.Ile515Thr Uncertain significance Single submitter
- ZW10 p.Ile674Val Uncertain significance Single submitter
- ZW10 p.Ile70Val Uncertain significance Single submitter
- ZW10 p.Leu228Phe Uncertain significance Single submitter
- ZW10 p.Leu248Arg Uncertain significance Single submitter
- ZW10 p.Leu316Met Uncertain significance Single submitter
- ZW10 p.Leu338Ser Uncertain significance Single submitter
- ZW10 p.Leu552Phe Uncertain significance Single submitter
- ZW10 p.Lys130Asn Uncertain significance Single submitter
- ZW10 p.Lys707Glu Uncertain significance Single submitter
- ZW10 p.Met221Leu Uncertain significance Single submitter
- ZW10 p.Met281Lys Uncertain significance Single submitter
- ZW10 p.Met329Ile Uncertain significance Single submitter
- ZW10 p.Met729Thr Uncertain significance Single submitter
- ZW10 p.Pro255Leu Uncertain significance Single submitter
- ZW10 p.Pro427Thr Uncertain significance Single submitter
- ZW10 p.Pro434Thr Uncertain significance Single submitter
- ZW10 p.Pro535Ser Uncertain significance Single submitter
- ZW10 p.Ser500Gly Uncertain significance Single submitter
- ZW10 p.Ser662Thr Uncertain significance Single submitter
- ZW10 p.Ser701Phe Uncertain significance Single submitter
- ZW10 p.Thr167Ala Uncertain significance Single submitter
- ZW10 p.Thr282Ile Uncertain significance Single submitter
- ZW10 p.Thr476Ala Uncertain significance Single submitter
- ZW10 p.Tyr349His Uncertain significance Single submitter
- ZW10 p.Tyr716Phe Uncertain significance Single submitter
- ZW10 p.Val233Ala Uncertain significance Single submitter
- ZW10 p.Val757Leu Uncertain significance Single submitter
Predictors split 16
The independent predictors disagree with each other — read with care.
- ZW10 p.Ala497Gly Uncertain significance Single submitter
- ZW10 p.Ala776Pro Uncertain significance Single submitter
- ZW10 p.Arg478Ser Uncertain significance Single submitter
- ZW10 p.Arg603Ser Uncertain significance Single submitter
- ZW10 p.Arg627Trp Uncertain significance Single submitter
- ZW10 p.Asn394Tyr Uncertain significance Single submitter
- ZW10 p.Cys545Ser Uncertain significance Single submitter
- ZW10 p.Gln111Pro Uncertain significance Single submitter
- ZW10 p.Gly556Glu Uncertain significance Single submitter
- ZW10 p.Leu347Phe Uncertain significance Single submitter
- ZW10 p.Phe559Ile Uncertain significance Single submitter
- ZW10 p.Pro699Ser Uncertain significance Single submitter
- ZW10 p.Ser213Trp Uncertain significance Single submitter
- ZW10 p.Ser225Ile Uncertain significance Single submitter
- ZW10 p.Ser52Arg Uncertain significance Single submitter
- ZW10 p.Val578Leu Uncertain significance Single submitter
All ZW10 variants
Likely benign 4
- p.Arg137His Single submitter
- p.Met221Val Single submitter
- p.Ser268Asn Single submitter
- p.Thr314Ala Single submitter
Uncertain significance 95
- p.Ala327Thr Single submitter ⚠
- p.Ala392Ser Single submitter ⚠
- p.Ala490Thr Single submitter ⚠
- p.Ala497Gly Single submitter ⚠
- p.Ala505Thr Single submitter ⚠
- p.Ala538Thr Single submitter ⚠
- p.Ala56Val Single submitter ⚠
- p.Ala652Val Single submitter ⚠
- p.Ala751Val Single submitter ⚠
- p.Ala772Glu Single submitter ⚠
- p.Ala774Thr Single submitter ⚠
- p.Ala776Pro Single submitter ⚠
- p.Arg137Cys Single submitter ⚠
- p.Arg151Gly Single submitter ⚠
- p.Arg276His Single submitter ⚠
- p.Arg393Cys Single submitter ⚠
- p.Arg478Gly Single submitter ⚠
- p.Arg478His Single submitter ⚠
- p.Arg478Ser Single submitter ⚠
- p.Arg562Cys Single submitter ⚠
- p.Arg562His Single submitter ⚠
- p.Arg603Gly Single submitter
- p.Arg603Ser Single submitter ⚠
- p.Arg627Gln Single submitter ⚠
- p.Arg627Trp Single submitter ⚠
- p.Arg635Lys Single submitter ⚠
- p.Arg762His Single submitter ⚠
- p.Asn394Tyr Single submitter ⚠
- p.Asn401His Single submitter ⚠
- p.Asn401Lys Single submitter ⚠
- p.Asn767His Single submitter ⚠
- p.Asp155Tyr Single submitter ⚠
- p.Asp428Ala Single submitter ⚠
- p.Asp440Gly Single submitter ⚠
- p.Asp442Tyr Single submitter ⚠
- p.Cys545Ser Single submitter ⚠
- p.Cys568Arg Single submitter ⚠
- p.Cys588Tyr Single submitter ⚠
- p.Gln111Pro Single submitter ⚠
- p.Gln628Arg Single submitter
- p.Glu121Gly Single submitter ⚠
- p.Glu205Lys Single submitter ⚠
- p.Glu267Lys Single submitter ⚠
- p.Glu278Ala Single submitter ⚠
- p.Glu462Gln Single submitter ⚠
- p.Glu529Lys Single submitter ⚠
- p.Glu692Lys Single submitter ⚠
- p.Glu769Asp Single submitter ⚠
- p.Glu78Lys Single submitter ⚠
- p.Gly556Glu Single submitter ⚠
- p.Gly90Ser Single submitter ⚠
- p.His517Tyr Single submitter ⚠
- p.His550Asp Single submitter ⚠
- p.His557Tyr Single submitter ⚠
- p.Ile185Leu Single submitter ⚠
- p.Ile185Thr Single submitter ⚠
- p.Ile395Val Single submitter ⚠
- p.Ile515Thr Single submitter ⚠
- p.Ile674Val Single submitter ⚠
- p.Ile70Val Single submitter ⚠
- p.Ile77Thr Single submitter
- p.Leu202Pro Single submitter
- p.Leu228Phe Single submitter ⚠
- p.Leu248Arg Single submitter ⚠
- p.Leu316Met Single submitter ⚠
- p.Leu338Ser Single submitter ⚠
- p.Leu347Phe Single submitter ⚠
- p.Leu552Phe Single submitter ⚠
- p.Lys130Asn Single submitter ⚠
- p.Lys707Glu Single submitter ⚠
- p.Met221Leu Single submitter ⚠
- p.Met281Lys Single submitter ⚠
- p.Met329Ile Single submitter ⚠
- p.Met729Thr Single submitter ⚠
- p.Phe559Ile Single submitter ⚠
- p.Pro255Leu Single submitter ⚠
- p.Pro427Thr Single submitter ⚠
- p.Pro434Thr Single submitter ⚠
- p.Pro535Ser Single submitter ⚠
- p.Pro699Ser Single submitter ⚠
- p.Ser213Trp Single submitter ⚠
- p.Ser225Ile Single submitter ⚠
- p.Ser500Gly Single submitter ⚠
- p.Ser52Arg Single submitter ⚠
- p.Ser662Thr Single submitter ⚠
- p.Ser701Phe Single submitter ⚠
- p.Thr167Ala Single submitter ⚠
- p.Thr282Ile Single submitter ⚠
- p.Thr476Ala Single submitter ⚠
- p.Tyr349His Single submitter ⚠
- p.Tyr716Phe Single submitter ⚠
- p.Val233Ala Single submitter ⚠
- p.Val407Met Single submitter
- p.Val578Leu Single submitter ⚠
- p.Val757Leu Single submitter ⚠