ZYX — 108 ClinVar variants

All ClinVar germline ZYX variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 93 flagged for review →

1 Conflicting · 4 Benign · 9 Likely benign · 94 Uncertain significance

Full ZYX gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions

⚑ Evidence disagreements 93

Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.

Predictors agree, ClinVar conflicts 1

ClinVar submitters conflict, but the independent predictors unanimously agree — a QC review flag, not a reclassification.

ZYX p.Gly193Asp Conflicting Single submitter

Predictors lean, ClinVar uncertain 71

ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.

Predictors split 21

The independent predictors disagree with each other — read with care.

All ZYX variants

Conflicting classifications of pathogenicity 1

p.Gly193Asp Single submitter ⚠

Benign 4

p.Ala400= Multiple submitters
p.Ile63Ser Multiple submitters ⚠
p.Thr459= Multiple submitters
p.Thr480= Multiple submitters

Likely benign 9

p.Ala92= Single submitter
p.Arg386Gln Single submitter
p.Glu123= Single submitter
p.Ile131Thr Single submitter
p.Leu247Ser Single submitter
p.Pro210Ser Single submitter
p.Pro334Ala Single submitter
p.Pro64= Single submitter
p.Val238= Single submitter

Uncertain significance 94

p.Ala107Glu Single submitter ⚠
p.Ala216Gly Single submitter ⚠
p.Ala317Val Single submitter ⚠
p.Ala408Ser Single submitter ⚠
p.Ala416Val Single submitter ⚠
p.Ala430Val Single submitter ⚠
p.Ala487Ser Single submitter ⚠
p.Ala487Thr Single submitter ⚠
p.Ala501Thr Single submitter ⚠
p.Ala525Thr Single submitter ⚠
p.Ala52Thr Single submitter ⚠
p.Ala92Asp Single submitter ⚠
p.Ala92Gly Single submitter ⚠
p.Arg167Leu Single submitter ⚠
p.Arg324Gln Single submitter ⚠
p.Arg343Cys Single submitter ⚠
p.Arg343His Single submitter ⚠
p.Arg393Trp Single submitter ⚠
p.Arg399Cys Single submitter
p.Arg454Cys Single submitter ⚠
p.Arg475His Single submitter ⚠
p.Arg563Trp Single submitter ⚠
p.Arg59Gly Single submitter ⚠
p.Asp145Gly Single submitter ⚠
p.Asp557Asn Single submitter ⚠
p.Asp84Tyr Single submitter ⚠
p.Gln294Lys Single submitter ⚠
p.Gln326Arg Single submitter ⚠
p.Gln337Glu Single submitter ⚠
p.Gln339His Single submitter ⚠
p.Gln422Arg Single submitter ⚠
p.Gln53Lys Single submitter ⚠
p.Glu101Lys Single submitter ⚠
p.Glu102Gly Single submitter ⚠
p.Glu139Lys Single submitter ⚠
p.Glu300Lys Single submitter ⚠
p.Glu321Gln Single submitter ⚠
p.Glu434Gln Single submitter ⚠
p.Glu449Val Single submitter ⚠
p.Glu45Lys Single submitter ⚠
p.Gly125Glu Single submitter ⚠
p.Gly192Arg Single submitter ⚠
p.Gly305Ser Single submitter ⚠
p.Gly385Ser Single submitter ⚠
p.Gly51Arg Single submitter ⚠
p.Gly51Glu Single submitter ⚠
p.His237Arg Single submitter ⚠
p.His237Leu Single submitter ⚠
p.His237Tyr Single submitter ⚠
p.His413Asp Single submitter ⚠
p.Ile100Leu Single submitter ⚠
p.Ile113Leu Single submitter ⚠
p.Ile546Ser Single submitter ⚠
p.Leu151Pro Single submitter ⚠
p.Leu401Val Single submitter
p.Leu544Met Single submitter ⚠
p.Met370Val Single submitter
p.Met512Val Single submitter ⚠
p.Phe222Leu Single submitter ⚠
p.Phe266Ser Single submitter ⚠
p.Pro108Leu Single submitter ⚠
p.Pro121Ser Single submitter ⚠
p.Pro198Leu Single submitter ⚠
p.Pro203His Single submitter ⚠
p.Pro213Leu Single submitter ⚠
p.Pro215Leu Single submitter ⚠
p.Pro230Leu Single submitter ⚠
p.Pro230Ser Single submitter ⚠
p.Pro260Leu Single submitter ⚠
p.Pro260Ser Single submitter ⚠
p.Pro275Leu Single submitter ⚠
p.Pro282Ser Single submitter ⚠
p.Pro312Leu Single submitter ⚠
p.Pro334Arg Single submitter ⚠
p.Pro350Ser Single submitter ⚠
p.Pro390Ala Single submitter ⚠
p.Pro41Ser Single submitter ⚠
p.Pro431Leu Single submitter ⚠
p.Pro510Thr Single submitter ⚠
p.Pro515Ser Single submitter ⚠
p.Pro64Arg Single submitter ⚠
p.Pro72Thr Single submitter ⚠
p.Pro77Leu Single submitter ⚠
p.Pro97Leu Single submitter ⚠
p.Ser267Phe Single submitter ⚠
p.Ser7Phe Single submitter ⚠
p.Thr315Ala Single submitter ⚠
p.Thr315Pro Single submitter ⚠
p.Thr459Met Single submitter ⚠
p.Tyr535Cys Single submitter ⚠
p.Val177Gly Single submitter ⚠
p.Val30Met Single submitter ⚠
p.Val521Leu Single submitter ⚠
p.Val560Met Single submitter ⚠